PennPET Explorer Scanner With Scalable Axial Length for Total Body PET Imaging

PennPET Explorer 扫描仪具有可扩展的轴向长度，适用于全身 PET 成像

• 批准号: 10304161
• 负责人: JOEL S KARP
• 金额: $ 58.41万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-05 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10304161
• 关键词: 3-Dimensional; Address; Adult; Beds; Biodistribution; Cancer Patient; Childhood; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Computer software; Data; Development Plans; Devices; Dimensions; Documentation; Dose; Electronics; Evaluation; Eye; Funding; Goals; Healthcare; Heart; Human; Image; Institution; Knowledge; Length; Lung; Malignant Neoplasms; Manufacturer Name; Medical; Methods; Oncology; Organ; PET/CT scan; Pathway interactions; Patients; Pediatric Oncology; Pennsylvania; Performance; Pharmaceutical Preparations; Pilot Projects; Population; Positron-Emission Tomography; Procedures; Radiation Dose Unit; Research; Research Personnel; Resources; Scanning; Software Design; Speed; System; Systems Biology; Systems Integration; Technology; Testing; Time; Translating; United States National Institutes of Health; Universities; Vendor; base; body system; cancer imaging; clinical diagnosis; clinical practice; clinically relevant; commercialization; computerized data processing; cost; cost effective; design; detector; digital; experience; flexibility; human subject; image reconstruction; imaging biomarker; improved; in vivo; in vivo imaging system; industry partner; instrument; meter; molecular imaging; pediatric patients; prototype; reconstruction; response; scale up; success; technology development; usability

PROJECT SUMMARY We propose to create an academic-industry partnership to develop commercially viable large-volume PET/CT scanners with a long axial field-of-view that will serve a wide range of applications in cancer from specialized clinical practice to advanced imaging biomarker research in clinical trials. The instrument will be scalable and offer the user a choice of axial field-of-view (AFOV) ranging from 70 cm to 210 cm. We propose an approach based on 70 cm axial segment lengths to provide optimal performance for the specific imaging tasks ranging from limited organ systems (e.g., lungs and heart) and pediatric torso imaging (one 70 cm segment) to full torso total-body adult imaging (2 - 3 segments or 140 - 210 cm). A 70 cm AFOV system, in particular, would provide a cost-effective size for pediatric patients with significant radiation dose reductions and reduced scan times for this population and a cost comparable to a PET/MR with standard AFOV. To achieve this goal we will create a partnership between the University of Pennsylvania, Philips Healthcare, and KAGE Medical, a new start-up venture, to develop the instrument such that it can translate Penn's Explorer prototype design to a commercial product. Specifically we will: 1) test and optimize performance of the 70 cm prototype Penn Explorer scanner and devise procedures to scale its range of axial lengths from 70-cm to 2.1-meters, 2) transfer the design to KAGE Medical to incorporate software design control, assembly and testing documentation, while also adding features for the end-user and improving the design to the functional level and reliability required for a commercial device, and 3) evaluate the system with a limited number of clinical pilot studies with a focus on the benefits of a 70 cm AFOV system for near-term clinically relevant applications, including adult and pediatric oncology imaging. There will be continuing cooperation with the team of clinical researchers at the University of Pennsylvania to transfer knowledge gained during the first human studies to optimize the instrument design and imaging performance as well as both patient and end-user experience in order to enhance its success as a commercial product. The purpose of our proposed AIP is to provide the resources for a commercial vendor to translate the design of our academic proto-type to a commercial product to offer other institutions the opportunity to explore potential applications of a long AFOV PET scanner, while also allowing us to implement this enhanced capability with Penn's Explorer, which will serve as the test-bed during the AIP project period.

项目总结 我们建议建立学术和行业合作伙伴关系，以开发具有商业可行性的大容量PET/CT 具有长轴视场的扫描仪，将在癌症中提供广泛的应用，从专门的 临床实践中的高级成像生物标志物研究在临床试验中。仪器将是可扩展的，并且 为用户提供从70厘米到210厘米的轴向视场(AFOV)选择。我们提出了一种方法 基于70厘米的轴线段长度，可为特定成像任务提供最佳性能 从有限的器官系统(例如，肺和心脏)和儿童躯干成像(一个70厘米的节段)到完整的 成人躯干全身摄像(2~3个节段或140~210 cm)。一个70厘米的AFOV系统，特别是，将 为显著减少辐射剂量和减少扫描的儿科患者提供经济实惠的尺寸 这一人群的时间和成本相当于带有标准AFOV的PET/MR。为了实现这一目标，我们将 在宾夕法尼亚大学、飞利浦医疗保健公司和新成立的KAGE医疗公司之间建立合作伙伴关系 风险，开发仪器，使其可以将宾夕法尼亚大学的探索者原型设计转化为商业产品。 具体来说，我们将：1)测试和优化70厘米原型宾夕法尼亚探索者扫描仪的性能，并 设计程序将其轴向长度范围从70厘米调整到2.1米，2)将设计转移到KAGE 医疗，以整合软件设计控制、组装和测试文档，同时还添加 面向最终用户的功能，并将设计改进到功能级别和可靠性 商业设备，以及3)通过有限数量的临床先导研究对该系统进行评估，重点是 70厘米AFOV系统用于近期临床相关应用的好处，包括成人和儿童 肿瘤学成像。将继续与华盛顿大学的临床研究团队合作 宾夕法尼亚州将转移在第一次人体研究中获得的知识，以优化仪器设计 和成像性能以及患者和最终用户体验，以增强其作为 商业产品。我们建议的AIP的目的是为商业供应商提供以下资源 将我们的学术原型设计转化为商业产品，为其他机构提供 有机会探索长型AFOV PET扫描仪的潜在应用，同时还允许我们实施 宾夕法尼亚大学的探索者增强了这一能力，它将在AIP项目期间作为试验台。