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PennPET Explorer Scanner With Scalable Axial Length for Total Body PET Imaging

PennPET Explorer 扫描仪具有可扩展的轴向长度，适用于全身 PET 成像

基本信息

批准号：
10524762
负责人：
JOEL S KARP
金额：
$ 58.03万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-12-05 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10524762
关键词：
3-Dimensional Address Adult Beds Biodistribution Cancer Patient Childhood Clinical Clinical Treatment Clinical Trials Computer software Data Development Plans Devices Dimensions Documentation Dose Electronics Evaluation Funding Goals Healthcare Heart Human Image Institution Knowledge Length Lung Malignant Neoplasms Manufacturer Marketing Medical Methods Oncology Organ PET/CT scan Pathway interactions Patients Pediatric Oncology Pennsylvania Performance Pharmaceutical Preparations Pilot Projects Population Positron-Emission Tomography Procedures Radiation Dose Unit Research Research Personnel Resources Scanning Software Design Speed System Systems Biology Systems Integration Technology Testing Time Translating United States National Institutes of Health Universities Vendor base body system cancer imaging clinical diagnosis clinical practice clinically relevant commercialization computerized data processing cost cost effective design detector digital experience flexibility human subject image reconstruction imaging biomarker improved in vivo in vivo imaging system industry partner instrument meter molecular imaging pediatric patients prototype reconstruction response success technology development usability

项目摘要

PROJECT SUMMARY We propose to create an academic-industry partnership to develop commercially viable large-volume PET/CT scanners with a long axial field-of-view that will serve a wide range of applications in cancer from specialized clinical practice to advanced imaging biomarker research in clinical trials. The instrument will be scalable and offer the user a choice of axial field-of-view (AFOV) ranging from 70 cm to 210 cm. We propose an approach based on 70 cm axial segment lengths to provide optimal performance for the specific imaging tasks ranging from limited organ systems (e.g., lungs and heart) and pediatric torso imaging (one 70 cm segment) to full torso total-body adult imaging (2 - 3 segments or 140 - 210 cm). A 70 cm AFOV system, in particular, would provide a cost-effective size for pediatric patients with significant radiation dose reductions and reduced scan times for this population and a cost comparable to a PET/MR with standard AFOV. To achieve this goal we will create a partnership between the University of Pennsylvania, Philips Healthcare, and KAGE Medical, a new start-up venture, to develop the instrument such that it can translate Penn's Explorer prototype design to a commercial product. Specifically we will: 1) test and optimize performance of the 70 cm prototype Penn Explorer scanner and devise procedures to scale its range of axial lengths from 70-cm to 2.1-meters, 2) transfer the design to KAGE Medical to incorporate software design control, assembly and testing documentation, while also adding features for the end-user and improving the design to the functional level and reliability required for a commercial device, and 3) evaluate the system with a limited number of clinical pilot studies with a focus on the benefits of a 70 cm AFOV system for near-term clinically relevant applications, including adult and pediatric oncology imaging. There will be continuing cooperation with the team of clinical researchers at the University of Pennsylvania to transfer knowledge gained during the first human studies to optimize the instrument design and imaging performance as well as both patient and end-user experience in order to enhance its success as a commercial product. The purpose of our proposed AIP is to provide the resources for a commercial vendor to translate the design of our academic proto-type to a commercial product to offer other institutions the opportunity to explore potential applications of a long AFOV PET scanner, while also allowing us to implement this enhanced capability with Penn's Explorer, which will serve as the test-bed during the AIP project period.

项目概要我们建议建立学术-工业合作伙伴关系，开发商业上可行的大容量 PET/CT 具有长轴向视场的扫描仪将在癌症领域提供广泛的应用临床试验中高级成像生物标志物研究的临床实践。该仪器将具有可扩展性为用户提供 70 厘米至 210 厘米范围内的轴向视场 (AFOV) 选择。我们提出一个方法基于 70 厘米轴向段长度，为特定成像任务提供最佳性能从有限的器官系统（例如肺和心脏）和儿科躯干成像（一个 70 厘米片段）到完整的成人躯干全身成像（2 - 3 个节段或 140 - 210 厘米）。特别是 70 厘米 AFOV 系统为儿科患者提供具有成本效益的尺寸，显着减少辐射剂量并减少扫描该人群的时间和成本与采用标准 AFOV 的 PET/MR 相当。为了实现这一目标，我们将宾夕法尼亚大学、飞利浦医疗保健公司和新初创企业 KAGE Medical 建立合作伙伴关系合资企业，开发该仪器，使其能够将宾夕法尼亚大学的探索者原型设计转化为商业产品。具体来说，我们将：1) 测试和优化 70 厘米原型 Penn Explorer 扫描仪的性能，以及设计程序将其轴向长度范围从 70 厘米扩展到 2.1 米，2) 将设计转移到 KAGE 医疗整合软件设计控制、组装和测试文档，同时还添加为最终用户提供功能，并将设计改进到所需的功能水平和可靠性商业设备，3) 通过有限数量的临床试点研究评估系统，重点是 70 cm AFOV 系统对于近期临床相关应用（包括成人和儿童）的优势肿瘤学成像。将与英国大学临床研究团队持续合作宾夕法尼亚州将转移在首次人体研究中获得的知识以优化仪器设计和成像性能以及患者和最终用户的体验，以提高其作为一个商业产品。我们提出的 AIP 的目的是为商业供应商提供资源将我们的学术原型的设计转化为商业产品，为其他机构提供有机会探索长 AFOV PET 扫描仪的潜在应用，同时也使我们能够实施 Penn Explorer 的增强功能将作为 AIP 项目期间的测试平台。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Total Body PET: Why, How, What for?

DOI：
10.1109/trpms.2020.2985403
发表时间：
2020-05
期刊：
IEEE transactions on radiation and plasma medical sciences
影响因子：
4.4
作者：
Surti S;Pantel AR;Karp JS
通讯作者：
Karp JS

Update on the PennPET Explorer: A Whole-body Imager with Scalable Axial Field-of-View.

PennPET Explorer 的更新：具有可扩展轴向视野的全身成像仪。

DOI：
10.1016/j.cpet.2020.09.002
发表时间：
2021
期刊：
PET clinics
影响因子：
2.6
作者：
Pantel,AustinR;Viswanath,Varsha;Karp,JoelS
通讯作者：
Karp,JoelS

Oncologic Applications of Long Axial Field-of-View PET/Computed Tomography.

DOI：
10.1016/j.cpet.2020.09.010
发表时间：
2021-01
期刊：
PET clinics
影响因子：
2.6
作者：
Nardo L;Pantel AR
通讯作者：
Pantel AR

Performance Characteristics of Long Axial Field-of-View PET Scanners with Axial Gaps.

DOI：
10.1109/trpms.2020.3027257
发表时间：
2021-05
期刊：
IEEE transactions on radiation and plasma medical sciences
影响因子：
4.4
作者：
Daube-Witherspoon ME;Viswanath V;Werner ME;Karp JS
通讯作者：
Karp JS

Total-Body PET: Will It Change Science and Practice?

全身 PET：它会改变科学和实践吗？

DOI：
10.2967/jnumed.121.263481
发表时间：
2022
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
0
作者：
Pantel,AustinR;Mankoff,DavidA;Karp,JoelS
通讯作者：
Karp,JoelS