PennPET Explorer Scanner With Scalable Axial Length for Total Body PET Imaging

项目概要 我们建议建立学术-工业合作伙伴关系，开发商业上可行的大容量 PET/CT 具有长轴向视场的扫描仪将在癌症领域提供广泛的应用 临床试验中高级成像生物标志物研究的临床实践。该仪器将具有可扩展性 为用户提供 70 厘米至 210 厘米范围内的轴向视场 (AFOV) 选择。我们提出一个方法 基于 70 厘米轴向段长度，为特定成像任务提供最佳性能 从有限的器官系统（例如肺和心脏）和儿科躯干成像（一个 70 厘米片段）到完整的 成人躯干全身成像（2 - 3 个节段或 140 - 210 厘米）。特别是 70 厘米 AFOV 系统 为儿科患者提供具有成本效益的尺寸，显着减少辐射剂量并减少扫描 该人群的时间和成本与采用标准 AFOV 的 PET/MR 相当。为了实现这一目标，我们将 宾夕法尼亚大学、飞利浦医疗保健公司和新初创企业 KAGE Medical 建立合作伙伴关系 合资企业，开发该仪器，使其能够将宾夕法尼亚大学的探索者原型设计转化为商业产品。 具体来说，我们将：1) 测试和优化 70 厘米原型 Penn Explorer 扫描仪的性能，以及 设计程序将其轴向长度范围从 70 厘米扩展到 2.1 米，2) 将设计转移到 KAGE 医疗整合软件设计控制、组装和测试文档，同时还添加 为最终用户提供功能，并将设计改进到所需的功能水平和可靠性 商业设备，3) 通过有限数量的临床试点研究评估系统，重点是 70 cm AFOV 系统对于近期临床相关应用（包括成人和儿童）的优势 肿瘤学成像。将与英国大学临床研究团队持续合作 宾夕法尼亚州将转移在首次人体研究中获得的知识以优化仪器设计 和成像性能以及患者和最终用户的体验，以提高其作为一个 商业产品。我们提出的 AIP 的目的是为商业供应商提供资源 将我们的学术原型的设计转化为商业产品，为其他机构提供 有机会探索长 AFOV PET 扫描仪的潜在应用，同时也使我们能够实施 Penn Explorer 的增强功能将作为 AIP 项目期间的测试平台。

PROJECT SUMMARY We propose to create an academic-industry partnership to develop commercially viable large-volume PET/CT scanners with a long axial field-of-view that will serve a wide range of applications in cancer from specialized clinical practice to advanced imaging biomarker research in clinical trials. The instrument will be scalable and offer the user a choice of axial field-of-view (AFOV) ranging from 70 cm to 210 cm. We propose an approach based on 70 cm axial segment lengths to provide optimal performance for the specific imaging tasks ranging from limited organ systems (e.g., lungs and heart) and pediatric torso imaging (one 70 cm segment) to full torso total-body adult imaging (2 - 3 segments or 140 - 210 cm). A 70 cm AFOV system, in particular, would provide a cost-effective size for pediatric patients with significant radiation dose reductions and reduced scan times for this population and a cost comparable to a PET/MR with standard AFOV. To achieve this goal we will create a partnership between the University of Pennsylvania, Philips Healthcare, and KAGE Medical, a new start-up venture, to develop the instrument such that it can translate Penn's Explorer prototype design to a commercial product. Specifically we will: 1) test and optimize performance of the 70 cm prototype Penn Explorer scanner and devise procedures to scale its range of axial lengths from 70-cm to 2.1-meters, 2) transfer the design to KAGE Medical to incorporate software design control, assembly and testing documentation, while also adding features for the end-user and improving the design to the functional level and reliability required for a commercial device, and 3) evaluate the system with a limited number of clinical pilot studies with a focus on the benefits of a 70 cm AFOV system for near-term clinically relevant applications, including adult and pediatric oncology imaging. There will be continuing cooperation with the team of clinical researchers at the University of Pennsylvania to transfer knowledge gained during the first human studies to optimize the instrument design and imaging performance as well as both patient and end-user experience in order to enhance its success as a commercial product. The purpose of our proposed AIP is to provide the resources for a commercial vendor to translate the design of our academic proto-type to a commercial product to offer other institutions the opportunity to explore potential applications of a long AFOV PET scanner, while also allowing us to implement this enhanced capability with Penn's Explorer, which will serve as the test-bed during the AIP project period.