Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses (mPRINT P50)

使用药物微生物组学和代谢组学分析优化母亲及其母乳喂养婴儿的抗生素 (mPRINT P50)

• 批准号: 10309712
• 负责人: ADRIANA H TREMOULET
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10309712
• 关键词: Administrator; Annual Reports; Antibiotic Therapy; Antibiotics; Biochemistry; Biology; Breastfed infant; Businesses; Childhood; Clinical Pharmacology; Collaborations; Communication; Effectiveness; Elements; Evaluation; Fostering; Future; Goals; Health Sciences; Human Milk; Infant Health; Infectious Disease Immunology; Knowledge; Lead; Leadership; Logistics; Maternal Health; Mentors; Milk; Mission; Mothers; Neonatal; Occupational activity of managing finances; Outcome Assessment; Preparation; Progress Reports; Publications; Recording of previous events; Records; Research; Research Activity; Research Project Grants; Research Training; Resources; Role; Therapeutic; Time; TimeLine; Training; Wood material; cohesion; experience; interest; metabolomics; microbiome; microbiome research; outreach; pediatric pharmacology; pharmacometrics; programs; science teacher; success

PROJECT SUMMARY for MPRINT CET ADMINISTRATIVE CORE The primary goal of the UCSD MPRINT CET is to serve as a national resource for knowledge and expertise in maternal and pediatric pharmacology. The Multi-PI leadership of the UCSD MPRINT CET, who will lead three Research Projects and two Support Cores (Milk Analytics and Pharmacometrics) excels in research fields of maternal and infant health, human milk, antibiotic therapeutics, pharmacometrics, metabolomics and microbiome. In order to successfully execute the goals of this program, we have formulated an Administrative Core that will facilitate the research activities and provide timely and responsible oversight of the UCSD MPRINT CET. The Specific Aims of the Administrative Core are: Aim 1: Provide leadership and oversight for the UCSD MPRINT CET to maximize effective execution of the research program and achieve all deliverables and milestones. The Administrative Core leadership (Drs. Tremoulet and Chambers) and program manager (Kristin Woods) have exceptional track-records in administration of multisite networks and will coordinate communication and overall cohesiveness among the various elements of the UCSD MPRINT CET and MPRINT Hub. The Administrative Core will oversee the preparation of annual reports and publications, as well as handle ongoing critical evaluation and outcomes assessment to achieve continual improvement of the MPRINT CET effectiveness. In so doing the Administrative Core will optimize evaluation, reprioritization and adjustment of activities, timelines and milestones. This Core will provide continuous and accurate financial management by tracking the financial status of the UCSD MPRINT CET Projects, Cores, and Support Pool. Aim 2: Facilitate the interactions of the UCSD MPRINT CET that will maximize the contributions to the MPRINT Hub The Administrative Core leadership will identify emerging needs across the UCSD MPRINT CET to choose Support Pool projects that will enhance the MPRINT Hub's role as a national resource in pediatric and maternal clinical pharmacology. The Administrative Core will lead the effort to select the most meritorious and impactful Support Pool projects. This Core will also be responsible for all communication with the MPRINT's Knowledge and Research Coordination Center (KRCC) and support outreach and dissemination of new knowledge by coordinating with the MPRINT KRCC's Outreach, Dissemination, and Training Core. Finally, the Administrative Core will provide an integrated educational and practical mentored research training experience in maternal and pediatric clinical pharmacology for health sciences professionals interested in becoming leaders in the field. In achieving these aims, the Administrative Core will achieve its mission of fostering communication and collaboration across the Research Projects and Cores at UCSD, as well as coordinate closely with the MPRINT KRCC and the entire MPRINT Hub.

MPRINT CET管理核心项目摘要 UCSD MPRINT CET的主要目标是作为知识和专业知识的国家资源， 母亲和儿科药理学。UCSD MPRINT CET的多PI领导层，将领导三个 研究项目和两个支持核心（牛奶分析和药物计量学）擅长以下研究领域： 母婴健康、母乳、抗生素治疗、药物计量学、代谢组学和 微生物组为了成功地实现这一计划的目标，我们制定了一个行政 核心，将促进研究活动，并提供及时和负责任的监督UCSD MPRINT CET.行政核心的具体目标是：目标1：领导和监督 UCSD MPRINT CET最大限度地有效执行研究计划，并实现所有可交付成果 和里程碑。行政核心领导（Tremoulet博士和Chambers博士）和项目经理 克里斯汀·伍兹（Kristin Woods）在管理多站点网络方面有着出色的记录， UCSD MPRINT CET和MPRINT各要素之间的沟通和整体凝聚力 枢纽行政核心将监督年度报告和出版物的编写，并处理 持续进行关键评估和结果评估，以实现MPRINT CET的持续改进 有效性在这样做的过程中，行政核心将优化评估、重新确定优先事项和调整 活动、时间表和里程碑。该核心将通过以下方式提供持续和准确的财务管理： 跟踪UCSD MPRINT CET项目、核心和支持池的财务状况。目标2：促进 UCSD MPRINT CET的互动将最大限度地提高对MPRINT中心的贡献。 行政核心领导将确定整个UCSD MPRINT CET的新需求，以选择支持 汇集项目，以加强MPRINT中心作为儿科和孕产妇临床资源的作用 药理学行政核心将领导选择最有价值和最有影响力的支持 泳池项目。该核心还将负责与MPRINT的知识进行所有通信， 研究协调中心（KRCC），并支持外联和传播新知识， 与MPRINT KRCC的外展、传播和培训核心协调。最后，行政 核心将提供一个综合的教育和实践指导研究培训经验，在孕产妇和 儿科临床药理学，为有兴趣成为该领域领导者的健康科学专业人员提供。在 实现这些目标，行政核心将实现其促进沟通的使命， 加州大学圣地亚哥分校研究项目和核心之间的合作，以及与MPRINT的密切协调 KRCC和整个MPRINT Hub。