Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses (mPRINT P50)

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PROJECT SUMMARY for MPRINT CET ADMINISTRATIVE CORE The primary goal of the UCSD MPRINT CET is to serve as a national resource for knowledge and expertise in maternal and pediatric pharmacology. The Multi-PI leadership of the UCSD MPRINT CET, who will lead three Research Projects and two Support Cores (Milk Analytics and Pharmacometrics) excels in research fields of maternal and infant health, human milk, antibiotic therapeutics, pharmacometrics, metabolomics and microbiome. In order to successfully execute the goals of this program, we have formulated an Administrative Core that will facilitate the research activities and provide timely and responsible oversight of the UCSD MPRINT CET. The Specific Aims of the Administrative Core are: Aim 1: Provide leadership and oversight for the UCSD MPRINT CET to maximize effective execution of the research program and achieve all deliverables and milestones. The Administrative Core leadership (Drs. Tremoulet and Chambers) and program manager (Kristin Woods) have exceptional track-records in administration of multisite networks and will coordinate communication and overall cohesiveness among the various elements of the UCSD MPRINT CET and MPRINT Hub. The Administrative Core will oversee the preparation of annual reports and publications, as well as handle ongoing critical evaluation and outcomes assessment to achieve continual improvement of the MPRINT CET effectiveness. In so doing the Administrative Core will optimize evaluation, reprioritization and adjustment of activities, timelines and milestones. This Core will provide continuous and accurate financial management by tracking the financial status of the UCSD MPRINT CET Projects, Cores, and Support Pool. Aim 2: Facilitate the interactions of the UCSD MPRINT CET that will maximize the contributions to the MPRINT Hub The Administrative Core leadership will identify emerging needs across the UCSD MPRINT CET to choose Support Pool projects that will enhance the MPRINT Hub's role as a national resource in pediatric and maternal clinical pharmacology. The Administrative Core will lead the effort to select the most meritorious and impactful Support Pool projects. This Core will also be responsible for all communication with the MPRINT's Knowledge and Research Coordination Center (KRCC) and support outreach and dissemination of new knowledge by coordinating with the MPRINT KRCC's Outreach, Dissemination, and Training Core. Finally, the Administrative Core will provide an integrated educational and practical mentored research training experience in maternal and pediatric clinical pharmacology for health sciences professionals interested in becoming leaders in the field. In achieving these aims, the Administrative Core will achieve its mission of fostering communication and collaboration across the Research Projects and Cores at UCSD, as well as coordinate closely with the MPRINT KRCC and the entire MPRINT Hub.