Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases

炎症和传染病的儿科和发育药理学

• 批准号: 9355662
• 负责人: ADRIANA H TREMOULET
• 金额: $ 27.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9355662
• 关键词: Address; Administrator; Advisory Committees; Anti-Inflammatory Agents; Anti-inflammatory; Award; Awareness; Basic Science; Biological Assay; Career Choice; Childhood; Clinical; Clinical Pharmacology; Clinical Sciences; Communicable Diseases; Communication; Communities; Decision Making; Development; Drug Kinetics; Education and Outreach; Effectiveness; Elements; Ensure; Evaluation; Evaluation Research; Event; Expenditure; Fostering; Funding; Future; Generations; Goals; Group Meetings; Health Sciences; Human Resources; Industry; Inflammatory; Journals; Lead; Leadership; Mentors; Monitor; National Institute of Child Health and Human Development; Nature; Organization and Administration; Outcome; Outcome Assessment; Pharmacology; Pilot Projects; Preparation; Process; Program Reviews; Progress Reports; Publications; Records; Reporting; Research; Research Activity; Research Infrastructure; Research Personnel; Research Training; Resources; Retreatment; Science; Series; Specialized Center; Subgroup; System; Time; Training; United States National Institutes of Health; Work; antimicrobial; cohesion; cost effective; drug development; experience; interest; meetings; member; operation; pediatric department; pediatric pharmacology; pharmacodynamic model; pharmacokinetic model; programs; science teacher; success

Administrative Core Abstract The Administrative Core supports the program entitled “Pediatric and Developmental Pharmacology for Inflammatory and Infectious Diseases” as a Specialized Center in Research in Pediatric Developmental Pharmacology (RPDP) Program (U54) at UC San Diego. The goal of the Administrative Core is to make certain that the entire UC San Diego RPDP program functions as efficiently and optimally as possible via the following aims. In Aim 1, the Core will promote communication and overall cohesiveness among the various elements of the UC San Diego RPDP Center to ensure efficient operations. To that end, the Administrative Core will focus on organizing its group meetings, retreats, and journal clubs, and by addressing and solving any and all institutional issues that arise. In Aim 2, the Core will track the financial status of the UC San Diego RPDP Center and coordinate report generations for the IRB, FDA and NIH. In Aim 3 the Core will provide ongoing critical evaluation and outcomes assessment to achieve continual improvement of RPDP effectiveness by organizing independent external as well as internal reviews of the program. The Scientific Advisory Committee will serve a key role as its members evaluate the RPDP Center and lend their expertise to promote scientific progress. In Aim 4 the Core will promote the integration of cross-disciplinary research and will serve as point of contact for outside entities seeking to collaborate with the RPDP, including the NICHD, other NICHD-supported Pediatric Pharmacology Training (T32) Programs, other RPDP Centers and industry. Through Aim 5 the Core will coordinate the pilot project application process and monitor project execution and outcomes. With Aim 6 the Administrative Core will support the quantitative pharmacokinetic and pharmacodynamics (PK/PD) modeling needs of the Projects and provide timely, accurate, and cost effective quantitative assays in support of the analytical needs of the Projects through the establishment of a Clinical Pharmacology Section under the leadership of Dr. Edmund Capparelli, a leader in the field of pediatric PK/PD modeling. Through Aim 7 the Administrative Core will seek to continue the excellent track record of the UC San Diego RPDP in training pediatric clinical pharmacologists through a Training and Outreach Section, lead by Dr. Adriana Tremoulet, co-PI of a recently awarded NICHD-funded T32 in Clinical Pharmacology. This Training and Outreach Section will provide an integrated educational and practical mentored research training experience in pediatric clinical pharmacology for health sciences professionals interested in becoming leaders in the field. This will serve as the platform for cross-training across the RPDP Centers as well. Efficient organization, administration and communication is essential for overall RPDP Center success especially given the translational nature of the research. Our success over the last five years as an RPDP Center demonstrates our ability to effectively administrate such a Center and demonstrates our ability to promote the successful interactions between clinical and basic science investigators to advance the field of pediatric pharmacology.

行政核心摘要 行政核心支持题为“儿童和发育药理学， 炎症和感染性疾病”作为一个专门的研究中心，在儿科发育 药理学（RPDP）项目（U 54）。行政核心的目标是使 确保整个UC San Diego RPDP计划通过 的目标。在目标1中，核心将促进各组织之间的沟通和整体凝聚力。 加州大学圣地亚哥分校RPDP中心的元素，以确保有效的运作。为此，行政 核心将专注于组织其小组会议，务虚会和期刊俱乐部，并通过解决和解决 任何出现的制度性问题在目标2中，核心将跟踪加州大学圣地亚哥分校的财务状况 RPDP中心并协调IRB、FDA和NIH的报告生成。在目标3中， 持续的关键评价和结果评估，以实现RPDP的持续改进 通过组织独立的外部和内部审查程序的有效性。科学 咨询委员会将在其成员评估RPDP中心并将其专业知识用于 推动科学进步。在目标4中，核心将促进跨学科研究的整合， 将作为寻求与RPDP合作的外部实体的联络点，包括NICHD， 其他NICHD支持的儿科药理学培训（T32）计划，其他RPDP中心和行业。 通过目标5，核心将协调试点项目的申请过程，并监测项目的执行情况， 结果。根据目标6，管理核心将支持定量药代动力学， 药物动力学（PK/PD）建模需求，并提供及时、准确和具有成本效益的 定量分析，通过建立一个临床 药理学部门在儿科领域的领导者Edmund Capparelli博士的领导下 PK/PD建模。通过目标7，行政核心将努力继续保持 加州大学圣地亚哥分校RPDP通过培训和外联科培训儿科临床药理学家， 由Adriana Tremoulet博士领导，他是最近获得NICHD资助临床药理学T32的共同PI。这 培训和外联科将提供综合的教育和实践指导研究培训 有兴趣成为领导者的健康科学专业人员的儿科临床药理学经验 在外地这也将作为跨RPDP中心的交叉培训平台。高效 组织、管理和沟通对于整个RPDP中心的成功至关重要，特别是考虑到 研究的翻译性质。我们在过去五年中作为RPDP中心的成功证明了 我们有能力有效地管理这样一个中心，并证明我们有能力促进成功的 临床和基础科学研究人员之间的互动，以推进儿科药理学领域。