TNPRC Breeding Colony Expansion in Support of COVID-19 Research

TNPRC 育种群体扩张支持 COVID-19 研究

• 批准号: 10312323
• 负责人: L Lee HAMM
• 金额: $ 149.06万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-09 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312323
• 关键词: 2019-nCoV; Adult; Animal Experimentation; Animal Housing; Animals; Applied Research; Area; Award; Basic Science; Behavioral; Biomedical Research; Breeding; COVID-19; COVID-19 pandemic; COVID-19 treatment; COVID-19 vaccine evaluation; Caring; Containment; Development; Ensure; Equipment; Financial Support; Funding; Future; Goals; Grant; Health; Herpesvirus 1; Housing; Human; Human Resources; Income; Infant; Infrastructure; Institutes; Knowledge; Laboratories; Macaca mulatta; Medical; Mission; Modeling; Modernization; Parents; Pathogenesis; Personal Satisfaction; Persons; Population; Preventive; Primates; Privatization; Procedures; Production; Public Health; Reproducibility; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Retroviridae; Rotation; SIV; Sales; Schedule; Scientific Advances and Accomplishments; Scientist; Testing; Therapeutic; United States; United States National Institutes of Health; Viral; Virus; animal breeding; animal facility; animal resource; base; biomedical resource; cost; design; experimental study; flexibility; genetic testing; germ free condition; improved; mature animal; nonhuman primate; novel; offspring; pandemic disease; pressure; programs; transmission process; vaccine efficacy; vaccine safety; welfare

PROJECT SUMMARY/ABSTRACT The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) sponsored by the National Institutes of Health. The Center is dedicated to providing the infrastructure and support for basic and applied research efforts to advance scientific knowledge and improve human and animal health and wellbeing. The TNPRC has one of the largest specific pathogen free (SPF) rhesus monkey breeding colonies in the United States. Over the past five years this breeding colony produced between 200-900 infants a year and provided close to 2,000 animals for biomedical research programs. National need for these high-quality nonhuman primate models exceeds supply, and demand has increased in the face of the current SARS-CoV-2 pandemic. The pandemic has placed tremendous pressure on established specific pathogen free (SPF) rhesus macaque breeding colonies and threatens the capacity to provide sufficient animals for research. The TNPRC P51 base grant award (P51 OD011104) provides funds to maintain a self-sustaining population of healthy, behaviorally normal, genetically diverse, and well-characterized nonhuman primates for a broad range of research projects. This supplement to the P51 base grant will be used to add a housing enclosure unit and provide financial support for additional breeding animals for population expansion. The proposed enclosure has been designed to maximize capacity and flexibility for the available funding and to provide novel and proven environmental enhancement components. Support for breeding animals will cover costs associated with husbandry and veterinary medical care, viral testing, genetic testing, behavioral management, the preventive health program, and additional personnel to provide care. The housing enclosure development and support for breeding animals objectives are both within the goal of the Breeding Colony Management Program component of the parent award, “to maintain and improve, where possible, the health and characterization of the colonies so that only high-quality animals are utilized contributing to high quality and reproducible experiments.” The benefits realized from this improvement will expand the TNPRC SPF rhesus macaque research infrastructure to assure these colonies are sustainable and able to provide well characterized research models well into the future.

项目摘要/摘要 杜兰国家灵长类研究中心(TNPRC)是七个国家灵长类研究中心之一 (NPRCs)由美国国立卫生研究院赞助。该中心致力于提供基础设施 以及支持基础和应用研究工作，以促进科学知识和改善人与环境 动物健康和福祉。TNPRC拥有最大的无特定病原体(SPF)恒河猴之一 在美国的繁殖地。在过去的五年里，这个繁殖群体产生了200-900个 每年为婴儿提供近2000只动物，用于生物医学研究项目。全国对这些产品的需求 优质的非人类灵长类模型供不应求，面对当前的 SARS-CoV-2大流行。这种大流行给已经确定的无特定病原体的人带来了巨大的压力。 (SPF)恒河猴繁殖群体，并威胁到为研究提供足够动物的能力。 TNPRC P51基本补助金奖(P51 OD011104)提供资金，以维持自给自足的 健康，行为正常，基因多样化，特征良好的非人类灵长类动物，范围广泛 研究项目。 P51基本补助金的这一补充将用于增加一个住房围栏单元并提供财政支持 用于繁殖更多的动物以扩大种群。拟议的围栏设计为 最大限度地提高可用资金的容量和灵活性，并提供新颖且经过验证的环境 增强组件。对饲养动物的支持将支付与畜牧业和 兽医医疗、病毒检测、基因检测、行为管理、预防健康计划、 以及额外的人员来提供护理。畜舍围栏的开发和养殖动物的支持 目标都在父母奖的繁殖群体管理计划部分的目标范围内， “在可能的情况下，保持和改善殖民地的健康状况和特性，以便只有高质量的 动物被利用，为高质量和可重复的实验做出了贡献。由此实现的好处 改进将扩大TNPRC SPF猕猴研究基础设施，以确保这些群体 可持续发展，并能够在未来很好地提供有特色的研究模型。