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4:4 Investigation of opioid exposure and neurodevelopment (iOPEN)

4:4 阿片类药物暴露和神经发育的调查 (iOPEN)

基本信息

批准号：
10321798
负责人：
Veerle Bergink
金额：
$ 22.89万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10321798
关键词：
2019-nCoV Address Affect Age Attention Baseline Surveys Behavioral Biological Factors Birth Brain COVID-19 COVID-19 diagnosis COVID-19 pandemic Cessation of life Child Child Development Classification Clinical Management Coronavirus Country Data Data Collection Development Developmental Delay Disorders Diagnosis Disease Emotional Environment Environmental Risk Factor Event Exposure to Fetal Distress Goals Health Health behavior Human Human Development Incidence Income Individual Individual Differences Infant Infant Development Infection Inflammation Infrastructure Investigation Life Magnetic Resonance Imaging Measures Mental Health Mothers Myelin Neurocognitive New York City Newborn Infant Outcome Outcome Measure Outcome Study Perinatal Population Pregnancy Pregnant Women Premature Labor Protocols documentation Psychosocial Factor Psychosocial Stress Public Health Receiver Operating Characteristics Recording of previous events Reporting Research Research Personnel Risk Risk Factors SARS-CoV-2 infection Series Severity of illness Societies Stress Surveys System Testing Third Pregnancy Trimester United States National Institutes of Health Validation Variant Vertical Disease Transmission Vulnerable Populations Water Woman Work antenatal caregiving cohort contextual factors experience high dimensionality in utero infancy infant outcome multimodality myelination negative affect neurobehavioral neurodevelopment novel offspring opioid exposure pandemic disease postnatal pregnant prenatal prospective protective factors psychobiologic recruit relating to nervous system repository resilience sex tool

项目摘要

PROJECT SUMMARY The SARS-CoV-2 (COVID-19) pandemic represents the most significant environmental event in living history. Sixty-eight million people worldwide have fallen ill to this disease, and 1.5 million people have died. Amongst those at greatest risk are society’s most vulnerable populations, including pregnant women and their children. It is unclear whether and how COVID-19 illness during pregnancy impacts the development of the child, as well as whether the timing of illness has any influence over this effect. It is also unknown whether environmental factors may mitigate observed outcomes. The present study will examine neurobehavioral trajectories in 100 children, half of whom will be born to women with COVID-19 infection diagnoses during pregnancy. Infants will undergo prospective longitudinal assessments at 1-, 6-, 9- and 12-months, including MRI 1 month (N = 50) and 12 months (N = 100). Our central hypotheses are that (1) perinatal COVID-19 leads to differences in infant attention, affect, myelination, and systems-level neural functional connectivity and that (2) earlier timing of prenatal infection and illness severity increase risk for developmental delay. We will explore specific environmental factors with potential influence over the association between maternal prenatal COVID-19 infection and child outcomes, particularly pre- and postnatal psychological health and partner support. We will thus be able to meaningfully evaluate whether, and how, prenatal COVID-19 illness modifies neurobehavioral development of infants and will address how variation in maternal psychobiological health influences observed associations.

项目概要 SARS-CoV-2 (COVID-19) 大流行是人类历史上最重大的环境事件。全世界有 6800 万人患上这种疾病，150 万人死亡。其中面临最大风险的是社会最弱势群体，包括孕妇及其子女。目前尚不清楚怀孕期间的 COVID-19 疾病是否以及如何影响孩子的发育患病时间是否对这种效果有影响。环境是否也未知因素可能会减轻观察到的结果。本研究将检查 100 人的神经行为轨迹儿童，其中一半是在怀孕期间诊断出感染了 COVID-19 的妇女所生的。婴儿会在 1、6、9 和 12 个月时进行前瞻性纵向评估，包括 1 个月的 MRI (N = 50) 和 12 个月（N = 100）。我们的中心假设是 (1) 围产期 COVID-19 导致婴儿的差异注意力、情感、髓鞘形成和系统级神经功能连接，以及 (2) 较早的时间产前感染和疾病严重程度会增加发育迟缓的风险。我们将探讨具体对孕产妇产前 COVID-19 之间的关联具有潜在影响的环境因素感染和儿童结局，特别是产前和产后心理健康和伴侣支持。我们将因此能够有意义地评估产前 COVID-19 疾病是否以及如何改变神经行为婴儿的发育，并将解决观察到的母亲心理生物学健康变化如何影响的问题协会。