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4:4 Investigation of opioid exposure and neurodevelopment (iOPEN)

4:4 阿片类药物暴露和神经发育的调查 (iOPEN)

基本信息

批准号：
10321798
负责人：
Veerle Bergink
金额：
$ 22.89万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-30 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10321798
关键词：
2019-nCoV Address Affect Age Attention Baseline Surveys Behavioral Biological Factors Birth Brain COVID-19 COVID-19 diagnosis COVID-19 pandemic Cessation of life Child Child Development Classification Clinical Management Coronavirus Country Data Data Collection Development Developmental Delay Disorders Diagnosis Disease Emotional Environment Environmental Risk Factor Event Exposure to Fetal Distress Goals Health Health behavior Human Human Development Incidence Income Individual Individual Differences Infant Infant Development Infection Inflammation Infrastructure Investigation Life Magnetic Resonance Imaging Measures Mental Health Mothers Myelin Neurocognitive New York City Newborn Infant Outcome Outcome Measure Outcome Study Perinatal Population Pregnancy Pregnant Women Premature Labor Protocols documentation Psychosocial Factor Psychosocial Stress Public Health Receiver Operating Characteristics Recording of previous events Reporting Research Research Personnel Risk Risk Factors SARS-CoV-2 infection Series Severity of illness Societies Stress Surveys System Testing Third Pregnancy Trimester United States National Institutes of Health Validation Variant Vertical Disease Transmission Vulnerable Populations Water Woman Work antenatal caregiving cohort contextual factors experience high dimensionality in utero infancy infant outcome multimodality myelination negative affect neurobehavioral neurodevelopment novel offspring opioid exposure pandemic disease postnatal pregnant prenatal prospective protective factors psychobiologic recruit relating to nervous system repository resilience sex tool

项目摘要

PROJECT SUMMARY The SARS-CoV-2 (COVID-19) pandemic represents the most significant environmental event in living history. Sixty-eight million people worldwide have fallen ill to this disease, and 1.5 million people have died. Amongst those at greatest risk are society’s most vulnerable populations, including pregnant women and their children. It is unclear whether and how COVID-19 illness during pregnancy impacts the development of the child, as well as whether the timing of illness has any influence over this effect. It is also unknown whether environmental factors may mitigate observed outcomes. The present study will examine neurobehavioral trajectories in 100 children, half of whom will be born to women with COVID-19 infection diagnoses during pregnancy. Infants will undergo prospective longitudinal assessments at 1-, 6-, 9- and 12-months, including MRI 1 month (N = 50) and 12 months (N = 100). Our central hypotheses are that (1) perinatal COVID-19 leads to differences in infant attention, affect, myelination, and systems-level neural functional connectivity and that (2) earlier timing of prenatal infection and illness severity increase risk for developmental delay. We will explore specific environmental factors with potential influence over the association between maternal prenatal COVID-19 infection and child outcomes, particularly pre- and postnatal psychological health and partner support. We will thus be able to meaningfully evaluate whether, and how, prenatal COVID-19 illness modifies neurobehavioral development of infants and will address how variation in maternal psychobiological health influences observed associations.

项目总结新冠肺炎(SARS-CoV-2)大流行是人类历史上最重大的环境事件。全球已有6800万人患上这种疾病，150万人死亡。在这些人中面临最大风险的是社会上最脆弱的人群，包括孕妇及其子女。目前尚不清楚孕期新冠肺炎疾病是否以及如何影响孩子的发育至于疾病的时间是否对这种效果有任何影响。目前也不清楚环境保护是否因素可能会减轻观察到的结果。目前的研究将检查100名患者的神经行为轨迹儿童，其中一半将是怀孕期间被诊断患有新冠肺炎感染的妇女所生。婴儿会在1个月、6个月、9个月和12个月接受前瞻性纵向评估，包括1个月MRI(N=50)和 12个月(N=100)。我们的中心假设是：(1)围产期新冠肺炎导致婴儿发育不同注意力、情感、髓鞘形成和系统水平的神经功能连接以及(2)较早的时间产前感染和疾病严重程度增加了发育迟缓的风险。我们将探索具体的环境因素对孕期新冠肺炎相关性的潜在影响感染和儿童结局，特别是产前和产后心理健康和伴侣支持。我们会因此，能够有意义地评估产前新冠肺炎疾病是否以及如何改变神经行为并将解决如何观察到母亲心理生物健康的差异影响联想。