Planning and Updating in Frontoparietal Networks for Grasping

用于抓取的额顶网络的规划和更新

• 批准号: 10322054
• 负责人: SERGEI V ADAMOVICH
• 金额: $ 39.01万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10322054
• 关键词: Anatomy; Anterior; Architecture; Behavior; Brain; Brain region; Complex; Digit structure; Disease; Dorsal; Exhibits; Goals; Hand; Individual; Investigation; Knowledge; Limb structure; Location; Mechanics; Mediating; Mission; Modeling; Motion; Movement; Parietal; Pathway interactions; Phase; Population; Posture; Procedures; Process; Recovery; Rehabilitation therapy; Robotics; Role; Scientist; Sensory; Solid; Stroke; System; Techniques; Testing; Thinking; Transcranial magnetic stimulation; United States National Institutes of Health; Update; Upper Extremity; Validation; Visual; Work; arm; arm movement; clinically relevant; design; experience; flexibility; grasp; haptics; innovation; interest; intraparietal sulcus; movement analysis; neuromechanism; neuromuscular; neurophysiology; neuroregulation; public health relevance; relating to nervous system; response; sensory feedback; skills; stroke intervention; virtual reality environment

Abstract The control of movement, in spite of its seemingly effortless execution, belies a complex, multi-level collective of neuromuscular interactions tuned and coordinated through sensory experience. Efficient and flexible behavior in everyday contexts requires neural mechanisms that support rapid updating whenever objects around us, or even our own movements, are disrupted during ongoing motion. As a movement unfolds, the need for predictive or responsive control to correct for contextual perturbations changes. For example, the early stages of an action typically exhibit fast responses to perturbations, suggesting the existence of feed-forward processes that use internal models to predict the sensory consequences. On the other hand, later phases appear to employ continuous sensory feedback to adjust movements. While much is known about updating for postural and arm movements, very little is understood about the neural mechanisms of updating of dexterous movements of the hand as we interact with objects. While the reach-to-grasp cortical anatomy is well described, the causal functional roles of the regions still remain elusive. In particular, it is now becoming clear that the dominant framework which describes reach-to-grasp control as being under the control of independent frontoparietal channels is untenable because it does not explain recent empirical neurophysiological findings. Therefore, the current project aims to leverage non-invasive stimulation to induce transient cortical perturbations, paired with visual perturbations to the task goal and mechanical perturbations of the internal state of the limb, to causally evaluate the contributions of four critical brain regions in components of the reach-to-grasp action. The information derived from this work will provide a more solid background for our understanding of the functional organization of the frontoparietal reach-to-grasp network and, by extension, of hand-arm control coordination. This project will advance our empirical understanding of how dexterous updating of the upper limb, in particular reach-to-grasp actions, are orchestrated by the brain. The knowledge will be immediately applicable and translatable for rehabilitation of upper limb recovery in stroke and other similar disorders, by using error augmentation through visual and haptic platforms to facilitate skill reacquisition and identifying cortical targets for non-invasive neuromodulatory stimulation. These findings will be relevant to the mission of the NIH, with broad interest to clinicians and basic scientists, and will have direct

抽象的 尽管似乎毫不费力地执行了运动的控制，但掩盖了一个复杂的多层次集体 神经肌肉相互作用通过感官体验调节和协调。高效而灵活的行为 在日常情况下，需要神经机制，每当我们周围的对象或 即使是我们自己的动作，也会在持续的运动中受到破坏。随着运动的发展，需要预测 或响应式控制以纠正上下文扰动的变化。例如，动作的早期阶段 通常表现出对扰动的快速响应，表明存在使用的前进过程 内部模型以预测感觉后果。另一方面，以后的阶段似乎采用了 连续的感觉反馈以调整运动。虽然对更新姿势和手臂有很多了解 动作，关于更新灵巧运动的神经机制几乎没有理解 当我们与对象互动时手。虽然可以很好地描述触及毛皮的皮质解剖结构，但因果关系 该地区的功能作用仍然难以捉摸。特别是，现在越来越清楚 描述到达控制控制的框架是在独立额叶的控制之下 通道是站不住脚的，因为它不能解释最近的经验神经生理发现。因此， 当前的项目旨在利用非侵入性刺激来诱导短暂的皮质扰动，并与 视觉扰动肢体内部状态的任务目标和机械扰动 评估四个关键大脑区域在覆盖式作用的组成部分中的贡献。这 从这项工作中得出的信息将为我们理解功能提供更坚实的背景 额叶覆盖范围网络的组织以及手臂控制协调的扩展。 该项目将提高我们对上肢灵巧更新的经验理解，特别是 大脑策划的触及式动作。知识将立即适用，并且 可通过使用错误来翻译用于中风和其他类似疾病中上肢恢复的康复 通过视觉和触觉平台进行增强，以促进技能重新计算并确定皮质目标 用于非侵入性神经调节刺激。这些发现将与NIH的使命有关 临床医生和基础科学家的广泛兴趣，并将直接