Translational Neuroimaging & Neurophysiology Core

转化神经影像学

• 批准号: 10445284
• 负责人: JIANHUI ZHONG
• 金额: $ 18.51万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10445284
• 关键词: 3-Dimensional; Address; Adult; Anatomy; Animals; Archives; Biological Assay; Biological Markers; Brain; Brain imaging; Cell Nucleus; Cells; Child; Childhood; Cognitive; Collaborations; Collection; Complex; Computer software; Consult; Data; Data Analyses; Development; Disease; Disease Progression; Electrodes; Electroencephalography; Electrophysiology (science); Elements; Environment; Event-Related Potentials; Experimental Designs; Faculty; Frequencies; Functional Magnetic Resonance Imaging; Funding; Gait; Goals; Grant; Group Meetings; Human; Image; Imaging Device; Imaging Techniques; Individual; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Investigation; Learning; Letters; Link; Magnetic Resonance Imaging; Marker Discovery; Measurement; Measures; Medical center; Methodology; Methods; Modernization; Motion; Motor; Participant; Patients; Persons; Phenotype; Physiologic pulse; Population; Positron-Emission Tomography; Postdoctoral Fellow; Posture; Procedures; Protocols documentation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Sensory; Services; Spielmeyer-Vogt Disease; Students; Supervision; System; Techniques; Testing; Time; Training; Translational Research; United States National Institutes of Health; Universities; Virtual and Augmented reality; Walking; Work; analysis pipeline; animal data; auditory processing; base; college; computerized data processing; cost; data acquisition; data analysis pipeline; data repository; data submission; density; design; developmental disease; experience; experimental study; human data; imaging capabilities; imaging modality; imaging system; innovation; interest; investigator training; juvenile neuronal ceroid lipofuscinosis; member; molecular imaging; mouse model; multimodality; neuroimaging; neurophysiology; next generation; nonhuman primate; novel; patient population; reconstruction; recruit; relating to nervous system; repository; square foot; tool; transmission process; virtual; virtual reality environment; visual tracking

PROJECT SUMMARY Both new investigators with an interest in testing IDD-related hypotheses and experienced investigators who may wish to expand their research portfolios to address important IDD-related issues often find that there are structural barriers to entry into a new research path. High costs of modern imaging techniques, the specialized technical aspects of experimental design, data acquisition and analysis, as well as working with new patient populations can each constrain execution of important translational research. The purpose of the Translational Neurophysiology and Neuroimaging Core (TNN) is to provide access to a set of modern (if complex) tools, access to the professional expertise so that use of these tools can be productive, and access to an intellectual environment that encourages and supports new and ongoing research on IDDs. To accomplish these important goals, the TNN has a set of aims that include providing UR-IDDRC members access to human and small animal neuroimaging tools (3T and 9.4T MRI), human and small animal electroencephalography (EEG), Mobile Brain/Body Imaging, and access to pilot funding to defray the costs of using these tools to jump-start new IDD research. TNN faculty and staff will consult with investigators on the design of the experiment, assist with the implementation of protocols and train investigators and/or their trainees (postdocs and students) to perform the data processing and analyses. A monthly users group meeting also allows new investigators to learn about current protocols, capabilities and ongoing projects that might synergize with their own proposed work, and to develop collaborative relationships with other TNN investigators. In addition to this general support for UR-IDDRC members, the TNN core also supports the proposed research project “Bridging the translational divide from cells to patients: toward reliable neuro-markers of Batten disease.” Aim 1 of the research project proposes to investigate auditory processing in children with Juvenile Neuronal Ceroid Lipofuscinosis in an effort to construct a neurophysiological biomarker of disease progression. Aim 2 of the research project proposes develop an identical EEG-based neuromarkers in murine models of Batten disease. The TNN serves as the hub for murine model EEG and also human EEG in people with and without IDDs. The facilities and services described in this core will be key elements to successful completion of the Aims of the research project.

项目概要 既有兴趣测试 IDD 相关假设的新研究者，也有经验丰富的研究者 那些可能希望扩大研究范围以解决与 IDD 相关的重要问题的人通常会发现 是进入新研究道路的结构性障碍。现代成像技术成本高昂， 实验设计、数据采集和分析的专业技术方面，以及与 新的患者群体都会限制重要转化研究的执行。目的 转化神经生理学和神经影像核心 (TNN) 旨在提供对一组现代（如果 复杂）工具，获得专业知识，以便高效地使用这些工具，并获得 创造一个鼓励和支持 IDD 新的和正在进行的研究的知识环境。到 为了实现这些重要目标，TNN 有一系列目标，其中包括为 UR-IDDRC 成员提供 使用人类和小动物神经成像工具（3T 和 9.4T MRI）、人类和小动物 脑电图 (EEG)、移动脑/身体成像以及获得试点资金以支付费用 使用这些工具来启动新的 IDD 研究。 TNN 教职员工将就此事与调查人员协商 设计实验，协助实施方案并培训研究人员和/或其人员 受训人员（博士后和学生）进行数据处理和分析。每月一次的用户小组会议 还允许新的研究人员了解当前的协议、功能和正在进行的项目，这些项目可能 与他们自己提出的工作进行协同，并与其他 TNN 发展合作关系 调查人员。 除了对 UR-IDDDRC 成员的普遍支持之外，TNN 核心还支持拟议的 研究项目“弥合从细胞到患者的翻译鸿沟：寻找可靠的神经标记物” 巴顿病。”该研究项目的目标 1 提议调查患有以下疾病的儿童的听觉处理过程： 幼年神经元蜡质脂褐质沉着症试图构建疾病的神经生理学生物标志物 进展。该研究项目的目标 2 建议在小鼠中开发相同的基于脑电图的神经标记物 巴顿病模型。 TNN 是小鼠模型脑电图和人类脑电图的中心 有或没有 IDD。本核心描述的设施和服务将是成功的关键要素 完成研究项目的目标。