Translational Neuroimaging & Neurophysiology Core

项目摘要 既有对IDD相关假设测试感兴趣的新研究者，也有经验丰富的研究者 那些希望扩大其研究范围以解决与缺碘症有关的重要问题的人往往会发现， 是进入新研究道路的结构性障碍。现代成像技术的高成本， 实验设计，数据采集和分析的专业技术方面，以及与 新的患者群体可以各自限制重要转化研究的执行。的目的 翻译神经生理学和神经影像学核心（TNN）是提供一套现代（如果 复杂）的工具，获得专业知识，使这些工具的使用可以是富有成效的， 鼓励和支持对缺碘症进行新的和正在进行的研究的知识环境。到 为了实现这些重要目标，TNN制定了一系列目标，包括为UR-IDDRC成员提供 获得人类和小动物神经成像工具（3 T和9.4T MRI），人类和小动物 脑电图（EEG），移动的脑/身体成像，并获得试点资金，以支付费用， 使用这些工具来启动新的碘缺乏病研究。TNN的教职员工将与调查人员就 设计实验，协助实施方案，并培训研究人员和/或其 实习生（博士后和学生）进行数据处理和分析。每月一次的用户组会议 还允许新的调查人员了解当前的协议，能力和正在进行的项目， 与他们自己提出的工作协同，并与其他TNN发展合作关系 investigators. 除了对UR-IDDRC成员的一般支持外，TNN核心还支持拟议的 研究项目“桥接从细胞到患者的翻译鸿沟：走向可靠的神经标志物” 巴腾氏病”研究项目的目标1提出了调查儿童的听觉处理， 青少年神经元蜡样脂褐质沉积症的研究 进展本研究的目的二是开发一种在小鼠脑内具有相同特征的脑电标记物 Batten病模型TNN是小鼠模型EEG和人类EEG的中枢 有和没有IDDs本核心中描述的设施和服务将是成功的关键要素 完成研究项目的目标。

PROJECT SUMMARY Both new investigators with an interest in testing IDD-related hypotheses and experienced investigators who may wish to expand their research portfolios to address important IDD-related issues often find that there are structural barriers to entry into a new research path. High costs of modern imaging techniques, the specialized technical aspects of experimental design, data acquisition and analysis, as well as working with new patient populations can each constrain execution of important translational research. The purpose of the Translational Neurophysiology and Neuroimaging Core (TNN) is to provide access to a set of modern (if complex) tools, access to the professional expertise so that use of these tools can be productive, and access to an intellectual environment that encourages and supports new and ongoing research on IDDs. To accomplish these important goals, the TNN has a set of aims that include providing UR-IDDRC members access to human and small animal neuroimaging tools (3T and 9.4T MRI), human and small animal electroencephalography (EEG), Mobile Brain/Body Imaging, and access to pilot funding to defray the costs of using these tools to jump-start new IDD research. TNN faculty and staff will consult with investigators on the design of the experiment, assist with the implementation of protocols and train investigators and/or their trainees (postdocs and students) to perform the data processing and analyses. A monthly users group meeting also allows new investigators to learn about current protocols, capabilities and ongoing projects that might synergize with their own proposed work, and to develop collaborative relationships with other TNN investigators. In addition to this general support for UR-IDDRC members, the TNN core also supports the proposed research project “Bridging the translational divide from cells to patients: toward reliable neuro-markers of Batten disease.” Aim 1 of the research project proposes to investigate auditory processing in children with Juvenile Neuronal Ceroid Lipofuscinosis in an effort to construct a neurophysiological biomarker of disease progression. Aim 2 of the research project proposes develop an identical EEG-based neuromarkers in murine models of Batten disease. The TNN serves as the hub for murine model EEG and also human EEG in people with and without IDDs. The facilities and services described in this core will be key elements to successful completion of the Aims of the research project.