Translational Neuroimaging & Neurophysiology Core

项目总结 既有对检验IDD相关假说感兴趣的新研究者，也有经验丰富的研究者 希望扩大他们的研究组合以解决与IDD相关的重要问题的人经常发现 是进入一条新的研究道路的结构性障碍。现代成像技术的高成本， 实验设计、数据采集和分析的专门技术方面，以及与 新的患者群体可能会限制重要转化性研究的执行。该计划的目的是 翻译神经生理学和神经成像核心(TNN)是提供一套现代(IF) 复杂)工具、获得专业专业知识以便能够高效地使用这些工具，以及访问 鼓励和支持有关IDDS的新的和正在进行的研究的智力环境。至 为了实现这些重要目标，TNN有一套目标，包括提供UR-IDDRC成员 可使用人类和小动物神经成像工具(3T和9.4T核磁共振)、人和小动物 脑电(EEG)、移动大脑/身体成像，以及获得试点资金以支付 使用这些工具启动新的IDD研究。TNN教职员工将与调查人员就 设计实验，协助实施方案，并培训调查人员和/或他们 受训人员(博士后和学生)进行数据处理和分析。每月一次的用户小组会议 还允许新调查人员了解当前的协议、功能和正在进行的项目，这些项目可能 与他们自己提议的工作协同，并与其他TNN发展协作关系 调查人员。 除了对UR-IDDRC成员的这一一般性支持外，TNN核心还支持拟议的 研究项目“跨越细胞与患者之间的翻译鸿沟：迈向可靠的神经标记物” 巴顿病的症状。“研究项目的第一个目标是研究儿童的听觉处理。 青少年神经元样脂褐质沉着症构建神经生理学疾病生物标志物 进步。研究项目的目标2建议在小鼠身上开发一种相同的基于脑电的神经标志物 巴顿病的模型。TNN是小鼠模型脑电和人类脑电的中枢 有无IDDS。这一核心中描述的设施和服务将是成功的关键要素 完成研究项目的目标。

PROJECT SUMMARY Both new investigators with an interest in testing IDD-related hypotheses and experienced investigators who may wish to expand their research portfolios to address important IDD-related issues often find that there are structural barriers to entry into a new research path. High costs of modern imaging techniques, the specialized technical aspects of experimental design, data acquisition and analysis, as well as working with new patient populations can each constrain execution of important translational research. The purpose of the Translational Neurophysiology and Neuroimaging Core (TNN) is to provide access to a set of modern (if complex) tools, access to the professional expertise so that use of these tools can be productive, and access to an intellectual environment that encourages and supports new and ongoing research on IDDs. To accomplish these important goals, the TNN has a set of aims that include providing UR-IDDRC members access to human and small animal neuroimaging tools (3T and 9.4T MRI), human and small animal electroencephalography (EEG), Mobile Brain/Body Imaging, and access to pilot funding to defray the costs of using these tools to jump-start new IDD research. TNN faculty and staff will consult with investigators on the design of the experiment, assist with the implementation of protocols and train investigators and/or their trainees (postdocs and students) to perform the data processing and analyses. A monthly users group meeting also allows new investigators to learn about current protocols, capabilities and ongoing projects that might synergize with their own proposed work, and to develop collaborative relationships with other TNN investigators. In addition to this general support for UR-IDDRC members, the TNN core also supports the proposed research project “Bridging the translational divide from cells to patients: toward reliable neuro-markers of Batten disease.” Aim 1 of the research project proposes to investigate auditory processing in children with Juvenile Neuronal Ceroid Lipofuscinosis in an effort to construct a neurophysiological biomarker of disease progression. Aim 2 of the research project proposes develop an identical EEG-based neuromarkers in murine models of Batten disease. The TNN serves as the hub for murine model EEG and also human EEG in people with and without IDDs. The facilities and services described in this core will be key elements to successful completion of the Aims of the research project.