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UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement

加州大学旧金山分校斯坦福子宫内膜异位症发现、创新、培训和社区参与中心

基本信息

批准号：
10458756
负责人：
LINDA C GIUDICE
金额：
$ 139.88万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458756
关键词：
Adaptive Immune System Address Affect Age Animal Model Area Aromatase Inhibitors Autoimmune Awareness Biological Markers Cardiovascular Diseases Cells Characteristics Chronic Cicatrix Classification Clinical Clinical Data Collaborations Communities Community Outreach Complex Computational Science Contraceptive Agents Coupled DNA Library Data Databases Diagnosis Discipline Disease Disease Management Disease stratification Dysmenorrhea Education Education and Outreach Endometrial Endometrium Environment Environmental Science Estradiol Estrogens Etiology Excision Fatigue Fertility Fostering Functional disorder GNRH1 gene Genetic Genomics Goals Health Health Expenditures Health Professional Heterogeneity Hormonal Human Immunologics Immunology Incidence Infectious Agent Infertility Inflammation Inflammatory Inflammatory Response Informatics Institution Lesion Life Machine Learning Malignant - descriptor Malignant Neoplasms Medical Mental Depression Mentors Mentorship Multiomic Data Non-Malignant Non-Steroidal Anti-Inflammatory Agents Operative Surgical Procedures Organ Outcome Pain Pain management Pathogenesis Pathology Patient-Focused Outcomes Pelvic Pain Pelvis Peritoneum Personal Satisfaction Pharmaceutical Preparations Phenotype Positioning Attribute Pregnancy Outcome Proteomics Quality of life Recurrence Research Research Personnel Research Project Grants Resolution Resources Risk Science Scientist Severities Steroids Students Surgeon Symptoms Systems Biology Technology Teenagers Tissue Banks Tissues Training Transcend United States National Institutes of Health Universities Uterus Validation Viral Woman Women&apos s Health analog biological specimen archives career career development chronic pelvic pain clinical care clinical phenotype clinically relevant community engagement comorbidity diagnostic biomarker diagnostic strategy disease classification disease diagnosis disease heterogeneity disease phenotype diversity and inclusion drug discovery drug repurposing economic impact endometriosis girls health disparity health economics human tissue improved innovation interdisciplinary collaboration member metabolomics minimally invasive multidisciplinary multiple omics next generation novel novel therapeutic intervention novel therapeutics pain relief pain symptom persistent organic pollutants phenotypic data precision medicine programs reproductive response response biomarker side effect student training systemic inflammatory response technological innovation therapeutic biomarker transcriptomics treatment response

项目摘要

ABSTRACT - OVERALL Endometriosis is a chronic, debilitating estrogen-dependent disease wherein tissue similar to the uterine lining (endometrium) is found mainly on pelvic tissues and organs where it causes an inflammatory response, scarring, pelvic pain, and infertility. It affects millions of reproductive age women and severely impacts quality of life and professional life, and has a huge health economic impact of about $69B annually in the U.S. While its etiology is uncertain, profound dysfunction of the innate and adaptive immune systems is associated with inefficient lesion clearance and pelvic and systemic inflammation. The heterogeneity of endometriosis lesions and disease phenotypes is reflected in variable pain symptom presentations, unpredictable fertility potential, uncertain disease pathophysiology, and unpredictable responses to medical therapies, symptom and disease recurrence after surgical resection, and risks for co-morbidities. Clinical classifications of endometriosis are maladapted to the heterogeneity of disease expression, and thus efficient treatments for associated pain symptoms are lacking. Herein, our UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement (“ENACT”) proposes a comprehensive systems biology and precision medicine approach to endometriosis. We propose to study endometriosis unmet needs and challenges through transdisciplinary collaboration and scientific and technologic innovations, integrating multi-omics data to dissect endometriosis disease mechanisms, identify phenotypic and environmental disease signatures, develop accurate disease stratification and diagnosis, and identify novel and repurposed drug classes to ameliorate pain symptoms. To achieve these goals, our Center is comprised of 3 independent and interactive projects and 2 Cores, focused on the central theme of Endometriosis Precision Medicine. Project 1 will focus on underlying immunological mechanisms in endometriosis pathogenesis and pathophysiology. Project 2 will address developing a multi- omic disease classification that will inform diagnostic strategies, and Project 3 will leverage existing and newly generated large-scale omic data to identify and validate new therapeutic interventions. Our long-standing Human Endometrial Tissue and DNA Bank and REDCap database and ongoing accruals with our collaborating network of surgeons will be a major resource for this Center's project. The Center will have an Administrative Core and an Education and Community Outreach Core that will engage students from the Bay Area in our research programs and empower women in our community and address health disparities associated with endometriosis. To achieve these goals, we have assembled a multi-disciplinary team of investigators at UCSF and Stanford University, many of whom are new to endometriosis research, as well as educators, trainees, and community representatives who are all committed to improve the lives of women and teen girls with endometriosis. Integrating multiple disciplines, fostering collaborations among those who are new to endometriosis, training the next generation and partnering with our community are key to the outcomes and impact of our Endometriosis Center.

摘要-总体