Natives Engaged in Alzheimer's Research

参与阿尔茨海默氏症研究的当地人

• 批准号: 10459235
• 负责人: DEDRA S BUCHWALD
• 金额: $ 293.82万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459235
• 关键词: Address; Adherence; Age; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Area; Awareness; Behavior Therapy; Behavioral Sciences; Blood specimen; Cataloging; Catalogs; Cholesterol; Clinic; Clinical; Clinical Sciences; Collection; Communities; Community Healthcare; DNA; Data; Dementia; Detection; Economic Burden; Economics; Elderly; Ensure; Family; Frequencies; Genetic Markers; Genetic Research; Genotype; Goals; Hawaiian; Health; Health Benefit; Healthcare Systems; High Prevalence; Hypertension; Impaired cognition; Indian reservation; Intervention; Island; Knowledge; Leadership; Life Expectancy; Minnesota; National Institute on Aging; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Native-Born; Neighborhood Health Center; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Obstructive Sleep Apnea; Patients; Persons; Physical activity; Population; Provider; Public Health; Quality of life; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Resources; Rural; Saliva; Sampling; Sleep Apnea Syndromes; Smoking; Social Sciences; Special Population; Testing; Training; Translating; Underrepresented Minority; Universities; Washington; Work; base; cognitive function; cohort; community partnership; dementia risk; disparity elimination; disparity reduction; effective intervention; effectiveness testing; experience; genetic risk factor; health disparity; high risk; improved; innovation; interest; low socioeconomic status; mild cognitive impairment; native elder; polygenic risk score; preservation; prevent; programs; public health research; randomized trial; recruit; repository; saliva sample; social; tribal community

OVERALL: ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias, as these conditions will soon have a major impact on their communities. Although AI/ANs and NHPIs share a high prevalence of ADRD risk factors, including hypertension and type 2 diabetes, their life expectancies have improved by as much as 30 years over the last 5 decades, resulting in a tripling of their populations’ share of people ages 65+. Unfortunately, the healthcare systems that serve AI/ANs and NHPIs are unprepared for the clinical, social, and economic, burdens associated with ADRD. The Natives Engaged in Alzheimer’s Research Center will be the only P01 to include AI/ANs or Native Hawaiians since the National Institute on Aging started cataloging P01s in 1984. Based at Washington State University, with collaborators at the University of Miami, Brigham Young University, and several other major universities, as well as with AI/AN and NHPI community partners, we will create an innovative program to understand, intervene on, and mitigate ADRD-related health disparities experienced by our priority populations. Our 3 Research Projects will be supported by Administrative, Research Methods, Recruitment and Engagement, and Biospecimen Cores. The Center will also feature a network of 8 Satellite Centers led by Native researchers that encompass areas where 90% of AI/ANs and NHPIs reside. These Satellite Centers will ensure that our work and our dissemination efforts are national in scope and help to create research-ready cohorts. The Center will unite scholars across social, clinical, and behavioral sciences. Notably, 12 AI/AN or NH/PI professionals have committed to participate as Investigators or Consultants. Thus, our Specific Aims are to: 1) In a group- randomized trial, test the effectiveness of a culturally informed provider training and “dementia-friendly clinic” intervention for detection and appropriate management of AI/AN patients with ADRD and mild cognitive impairment in at least 20 urban and rural clinics serving AI/ANs; 2) In a group-randomized controlled trial, test the effectiveness of a Hula intervention for preventing cognitive decline in NHPI elders with subjective cognitive impairments or mild cognitive impairment in the Hawaiian Islands; 3) In an observational study, screen AIs in 2 remote reservation communities for obstructive sleep apnea and cognitive impairment, then conduct a randomized controlled trial to test an intervention to improve adherence to sleep apnea treatment for improving or preserving cognitive function; 4) Genotype DNA from saliva samples, catalog the frequency of genetic markers for ADRD risk, and calculate polygenic risk scores for ADRD using biospecimens from 2,700+ AI/ANs and NHPIs; and 5) Create an innovative P01 to understand, intervene on, and mitigate ADRD disparities in AI/ANs and NHPIs. Our leadership, resources, and experience offer an unprecedented opportunity to address the National Institute on Aging’s research priorities for underrepresented minorities, as articulated in the National Plan to Address Alzheimer's Disease, and to respond directly to its interest in diversifying the scientific workforce.

总体：摘要 美国印第安人/阿拉斯加原住民（AI/AN）和夏威夷原住民和太平洋岛民（NHPIs）越来越多地 关注阿尔茨海默病和相关痴呆症，因为这些疾病很快就会产生重大影响， 他们的社区。尽管AI/AN和NHPI具有ADRD风险因素的高患病率，包括 高血压和2型糖尿病，他们的预期寿命在过去5年中提高了30年之多。 几十年来，这些国家65岁以上人口的比例增加了两倍。不幸的是， 为人工智能/人工神经网络和国家医疗保健机构服务的系统没有为相关的临床、社会和经济负担做好准备 关于ADRD阿尔茨海默氏症研究中心的原住民将是唯一一个包括AI/AN的P01， 夏威夷原住民自1984年国家老龄化研究所开始编目P01以来。总部设在华盛顿 州立大学，与合作者在迈阿密大学，杨百翰大学，和其他几个主要的 大学，以及AI/AN和NHPI社区合作伙伴，我们将创建一个创新计划， 了解，干预，并减轻我们的优先人群经历的ADRD相关的健康差异。 我们的3个研究项目将由行政，研究方法，招聘和参与支持， 和生物样本核心该中心还将拥有由本土研究人员领导的8个卫星中心网络 包括90%的AI/AN和NHPI居住的地区。这些卫星中心将确保我们的工作 我们的传播工作是全国性的，有助于建立研究准备就绪的群体。该中心将 联合社会、临床和行为科学领域的学者。值得注意的是，12名AI/AN或NH/PI专业人员 承诺作为研究者或顾问参与。因此，我们的具体目标是：1）在一组- 随机试验，测试文化上知情的提供者培训和"痴呆友好诊所"的有效性 对伴有ADRD和轻度认知障碍AI/AN患者的检测和适当管理的干预 在至少20个城市和农村诊所提供AI/AN的损害; 2）在一项分组随机对照试验中，测试 Hula干预对预防NHPI老年人认知功能下降的有效性 在夏威夷群岛的认知障碍或轻度认知障碍; 3）在一项观察性研究中， 阻塞性睡眠呼吸暂停和认知障碍的2个远程预约社区，然后进行 一项随机对照试验，旨在测试干预措施，以改善睡眠呼吸暂停治疗的依从性， 4）唾液样本的基因型DNA，对遗传频率进行分类， ADRD风险标志物，并使用来自2，700 + AI/AN的生物标本计算ADRD的多基因风险评分 5）创建一个创新的P01，以了解，干预和减轻ADRD差异， AI/AN和NHPI。我们的领导力、资源和经验提供了前所未有的机会， 国家老龄问题研究所对代表性不足的少数民族的研究优先事项，如国家 计划解决阿尔茨海默病，并直接回应其在科学劳动力多样化方面的兴趣。