Natives Engaged in Alzheimer's Research

参与阿尔茨海默氏症研究的当地人

• 批准号: 10459235
• 负责人: DEDRA S BUCHWALD
• 金额: $ 293.82万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459235
• 关键词: Address; Adherence; Age; Alaska Native; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Area; Awareness; Behavior Therapy; Behavioral Sciences; Blood specimen; Cataloging; Catalogs; Cholesterol; Clinic; Clinical; Clinical Sciences; Collection; Communities; Community Healthcare; DNA; Data; Dementia; Detection; Economic Burden; Economics; Elderly; Ensure; Family; Frequencies; Genetic Markers; Genetic Research; Genotype; Goals; Hawaiian; Health; Health Benefit; Healthcare Systems; High Prevalence; Hypertension; Impaired cognition; Indian reservation; Intervention; Island; Knowledge; Leadership; Life Expectancy; Minnesota; National Institute on Aging; Native Hawaiian; Native Hawaiian or Other Pacific Islander; Native-Born; Neighborhood Health Center; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Obstructive Sleep Apnea; Patients; Persons; Physical activity; Population; Provider; Public Health; Quality of life; Randomized Controlled Trials; Research; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Resources; Rural; Saliva; Sampling; Sleep Apnea Syndromes; Smoking; Social Sciences; Special Population; Testing; Training; Translating; Underrepresented Minority; Universities; Washington; Work; base; cognitive function; cohort; community partnership; dementia risk; disparity elimination; disparity reduction; effective intervention; effectiveness testing; experience; genetic risk factor; health disparity; high risk; improved; innovation; interest; low socioeconomic status; mild cognitive impairment; native elder; polygenic risk score; preservation; prevent; programs; public health research; randomized trial; recruit; repository; saliva sample; social; tribal community

OVERALL: ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias, as these conditions will soon have a major impact on their communities. Although AI/ANs and NHPIs share a high prevalence of ADRD risk factors, including hypertension and type 2 diabetes, their life expectancies have improved by as much as 30 years over the last 5 decades, resulting in a tripling of their populations’ share of people ages 65+. Unfortunately, the healthcare systems that serve AI/ANs and NHPIs are unprepared for the clinical, social, and economic, burdens associated with ADRD. The Natives Engaged in Alzheimer’s Research Center will be the only P01 to include AI/ANs or Native Hawaiians since the National Institute on Aging started cataloging P01s in 1984. Based at Washington State University, with collaborators at the University of Miami, Brigham Young University, and several other major universities, as well as with AI/AN and NHPI community partners, we will create an innovative program to understand, intervene on, and mitigate ADRD-related health disparities experienced by our priority populations. Our 3 Research Projects will be supported by Administrative, Research Methods, Recruitment and Engagement, and Biospecimen Cores. The Center will also feature a network of 8 Satellite Centers led by Native researchers that encompass areas where 90% of AI/ANs and NHPIs reside. These Satellite Centers will ensure that our work and our dissemination efforts are national in scope and help to create research-ready cohorts. The Center will unite scholars across social, clinical, and behavioral sciences. Notably, 12 AI/AN or NH/PI professionals have committed to participate as Investigators or Consultants. Thus, our Specific Aims are to: 1) In a group- randomized trial, test the effectiveness of a culturally informed provider training and “dementia-friendly clinic” intervention for detection and appropriate management of AI/AN patients with ADRD and mild cognitive impairment in at least 20 urban and rural clinics serving AI/ANs; 2) In a group-randomized controlled trial, test the effectiveness of a Hula intervention for preventing cognitive decline in NHPI elders with subjective cognitive impairments or mild cognitive impairment in the Hawaiian Islands; 3) In an observational study, screen AIs in 2 remote reservation communities for obstructive sleep apnea and cognitive impairment, then conduct a randomized controlled trial to test an intervention to improve adherence to sleep apnea treatment for improving or preserving cognitive function; 4) Genotype DNA from saliva samples, catalog the frequency of genetic markers for ADRD risk, and calculate polygenic risk scores for ADRD using biospecimens from 2,700+ AI/ANs and NHPIs; and 5) Create an innovative P01 to understand, intervene on, and mitigate ADRD disparities in AI/ANs and NHPIs. Our leadership, resources, and experience offer an unprecedented opportunity to address the National Institute on Aging’s research priorities for underrepresented minorities, as articulated in the National Plan to Address Alzheimer's Disease, and to respond directly to its interest in diversifying the scientific workforce.

总体：摘要 美洲印第安人/阿拉斯加原住民 (AI/AN) 以及夏威夷原住民和太平洋岛民 (NHPI) 越来越多 关注阿尔茨海默病和相关痴呆症，因为这些疾病很快就会产生重大影响 关于他们的社区。尽管 AI/AN 和 NHPI 都存在 ADRD 风险因素，包括 高血压和 2 型糖尿病患者的预期寿命在过去 5 年内提高了 30 年 几十年来，65 岁以上人口比例增加了两倍。不幸的是，医疗保健 为 AI/AN 和 NHPI 服务的系统没有做好应对相关临床、社会和经济负担的准备 与ADRD。参与阿尔茨海默病研究中心的当地人将是唯一一个包含 AI/AN 或 自 1984 年国家老龄化研究所开始对 P01 进行编目以来，夏威夷原住民就已存在。总部位于华盛顿 州立大学，与迈阿密大学、杨百翰大学和其他几所大学合作 大学以及 AI/AN 和 NHPI 社区合作伙伴，我们将创建一个创新计划 了解、干预和减轻我们的重点人群所经历的与 ADRD 相关的健康差异。 我们的 3 个研究项目将得到行政、研究方法、招聘和参与的支持， 和生物样本核心。该中心还将拥有由本土研究人员领导的 8 个卫星中心组成的网络 涵盖 90% AI/AN 和 NHPI 居住的区域。这些卫星中心将确保我们的工作 我们的传播工作在全国范围内进行，有助于创建做好研究准备的群体。该中心将 联合社会、临床和行为科学领域的学者。值得注意的是，12 位 AI/AN 或 NH/PI 专业人士拥有 承诺作为调查员或顾问参与。因此，我们的具体目标是： 1) 在一个团体中- 随机试验，测试文化知情的提供者培训和“痴呆症友好诊所”的有效性 对患有 ADRD 和轻度认知障碍的 AI/AN 患者进行检测和适当管理的干预措施 至少 20 个为 AI/AN 提供服务的城市和农村诊所受到损害； 2) 在分组随机对照试验中，测试 草裙舞干预对预防主观认知 NHPI 老年人认知能力下降的有效性 夏威夷群岛的障碍或轻度认知障碍； 3) 在观察性研究中，筛选人工智能 2个针对阻塞性睡眠呼吸暂停和认知障碍的远程预约社区，然后进行 随机对照试验测试一种干预措施，以提高对睡眠呼吸暂停治疗的依从性，以改善睡眠呼吸暂停治疗的效果 或保留认知功能； 4) 对唾液样本中的 DNA 进行基因分型，对遗传频率进行分类 ADRD 风险标记，并使用来自 2,700 多个 AI/AN 的生物样本计算 ADRD 的多基因风险评分 和 NHPI； 5) 创建一个创新的 P01，以了解、干预和减轻 ADRD 差异 AI/AN 和 NHPI。我们的领导力、资源和经验提供了前所未有的机会来解决 国家老龄化研究所针对代表性不足的少数群体的研究重点，如国家 计划解决阿尔茨海默病，并直接回应其对科学队伍多样化的兴趣。