Neuropsychological Profile and Neurocognitive Biomarkers of Attention and Memory in Trauma-Exposed Responders at Risk of Premature Cognitive Decline

具有过早认知衰退风险的创伤暴露反应者的注意力和记忆的神经心理学特征和神经认知生物标志物

基本信息

项目摘要

ABSTRACT Direct trauma exposure is associated with negative physical and mental health consequences, including an increased risk of rapid decline of cognitive function, which may start early in midlife. Moreover, additional life traumas such as COVID-19, as well as chronic illnesses, have also been shown to accelerate cognitive aging. During the World Trade Center terror attack and its aftermath, tens of thousands of traditional first responders and other cleanup and recovery workers were exposed to the emotional trauma and to environmental toxicants, and they had high rates of subsequent physical and psychiatric disorders. The time to detect cognitive decline is before the onset of more obvious symptoms, so that the underlying neurodegeneration may be delayed or lessened. To evaluate the risk of cognitive decline, we will use remote web-based neuropsychological tasks to assess core cognitive functioning among the youngest first responders (N=1,200) in two waves, 40 months apart. The different levels of trauma exposure, and consequent physical and mental outcomes, which have been well documented, may imply different levels of premature cognitive decline risk among the responders which will be considered in our experimental design and analytical models. We plan to recruit first responders who received health services through the WTC Health Program, a majority of whom were police and non-traditional rescue, recovery and cleanup workers, and compare the risk of cognitive decline between these groups. In addition, a sub-group of responders and additional community controls (N=120) will participate in a neurocognitive study using EEG and MRI to elucidate the neurobiological mechanisms associate with premature cognitive decline. Specifically, we will include core cognitive tasks (attention and episodic memory) to determine the neuronal underpinnings of early cognitive changes and will obtain measures of brain morphology and connectivity. This study will generate scientifically robust information to guide clinical and public health actions focused on premature cognitive decline among the youngest responders. A better understanding of premature cognitive decline and of the most important pathways causing such decline has the potential to improve interventions that can reduce premature cognitive decline in this and other cohorts.
抽象的 直接创伤暴露与负面的身心健康后果相关,包括 认知功能快速下降的风险增加,这种情况可能在中年早期就开始。此外,还有额外的生命 COVID-19 等创伤以及慢性疾病也被证明会加速认知衰老。 在世贸中心恐怖袭击及其后果期间,数以万计的传统急救人员 和其他清理和恢复工作人员都遭受了情感创伤和环境影响 有毒物质,而且他们随后出现身体和精神疾病的几率很高。检测时间 认知能力下降是在更明显的症状出现之前,使潜在的神经退行性变 可能会延迟或减少。为了评估认知能力下降的风险,我们将使用基于网络的远程 评估最年轻急救人员核心认知功能的神经心理学任务 (N=1,200) 分两波,相隔 40 个月。不同程度的创伤暴露,以及随之而来的身体和精神上的影响 已被充分记录的结果可能意味着不同程度的过早认知衰退风险 在我们的实验设计和分析模型中将考虑的响应者。我们计划 招募通过世贸中心健康计划接受医疗服务的急救人员,其中大多数人 是警察和非传统救援、恢复和清理人员,并比较认知风险 这些群体之间的下降。此外,还有一个响应者小组和额外的社区控制措施 (N=120) 将参加一项使用 EEG 和 MRI 的神经认知研究,以阐明神经生物学 与过早认知衰退相关的机制。具体来说,我们将包括核心认知任务 (注意力和情景记忆)确定早期认知变化和意志的神经元基础 获得大脑形态和连接性的测量。这项研究将产生科学可靠的信息 指导针对最年轻人群过早认知衰退的临床和公共卫生行动 响应者。更好地了解过早认知衰退和最重要的途径 造成这种下降有可能改善干预措施,从而减少过早的认知下降 这个群体和其他群体。

项目成果

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YAEL M CYCOWICZ其他文献

YAEL M CYCOWICZ的其他文献

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{{ truncateString('YAEL M CYCOWICZ', 18)}}的其他基金

Neuropsychological Profile and Neurocognitive Biomarkers of Attention and Memory in Trauma-Exposed Responders at Risk of Premature Cognitive Decline
具有过早认知衰退风险的创伤暴露反应者的注意力和记忆的神经心理学特征和神经认知生物标志物
  • 批准号:
    10314981
  • 财政年份:
    2021
  • 资助金额:
    $ 59.93万
  • 项目类别:
Neuropsychological Profile and Neurocognitive Biomarkers of Attention and Memory in Trauma-Exposed Responders at Risk of Premature Cognitive Decline
具有过早认知衰退风险的创伤暴露反应者的注意力和记忆的神经心理学特征和神经认知生物标志物
  • 批准号:
    10626777
  • 财政年份:
    2021
  • 资助金额:
    $ 59.93万
  • 项目类别:
Multimodal Neuroimaging of Cognitive and Emotional Networks in Young Adults Exposed to 9/11 as Children
儿童时期接触过 9/11 事件的年轻人的认知和情感网络的多模态神经影像
  • 批准号:
    9770631
  • 财政年份:
    2018
  • 资助金额:
    $ 59.93万
  • 项目类别:
DEVELOPMENT OF ORIENTING TO AND MEMORY FOR NOVELS EVENTS
对新奇事件的定向力和记忆力的发展
  • 批准号:
    2746865
  • 财政年份:
    1999
  • 资助金额:
    $ 59.93万
  • 项目类别:
DEVELOPMENT OF ORIENTING TO AND MEMORY FOR NOVELS EVENTS
对新奇事件的定向力和记忆力的发展
  • 批准号:
    6151175
  • 财政年份:
    1999
  • 资助金额:
    $ 59.93万
  • 项目类别:

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