Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus

急性胰腺炎相关糖尿病的流行病学和病理生理学

• 批准号: 10458663
• 负责人: DARWIN LEWIS CONWELL
• 金额: $ 27.14万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10458663
• 关键词: Accounting; Acinar Cell; Acute; Acute Necrotizing Pancreatitis; Address; Admission activity; Adult; Autoimmune; Biological; Biological Markers; Body Weight; Cell physiology; Clinical; Code; Cohort Studies; Complication; Data Set; Development; Diabetes Mellitus; Diagnostic; Disease; Elastases; Endocrine; Enrollment; Epidemiology; Exhibits; Exocrine pancreas; Exocrine pancreatic insufficiency; Fat-Soluble Vitamin; Feces; Frequencies; Functional disorder; Future; Goals; Incidence; Inflammatory; Insulin; Insulin-Dependent Diabetes Mellitus; Investigation; Islet Cell; Knowledge; Leadership; Liquid substance; Metabolic; Monitor; Morbidity - disease rate; Multicenter Studies; Multicenter Trials; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Non-Insulin-Dependent Diabetes Mellitus; OGTT; Ohio; Outcome; Pancreas; Pancreatic Hormones; Pathway interactions; Patients; Pattern; Play; Prediabetes syndrome; Prevention strategy; Prognostic Marker; Publishing; Research Infrastructure; Resuscitation; Risk Factors; Role; Sampling; Series; Serum; Standardization; Subgroup; Supportive care; Testing; Trypsin; Universities; Work; acute pancreatitis; base; biobank; blood glucose regulation; burden of illness; clinical center; clinical diagnosis; clinical predictors; cohort; design; diagnostic biomarker; epidemiologic data; follow-up; improved; incretin hormone; innovation; insulin secretion; insulin sensitivity; interest; member; mortality; multidisciplinary; prevent; prospective; response; risk stratification; translational study; treatment strategy

Project Summary/Abstract Acute pancreatitis is a common inflammatory disorder with short- and long-term clinical sequelae. The development of diabetes mellitus following an episode of acute pancreatitis (termed AP-related DM) is now recognized in approximately 25% of patients; however, its epidemiology and pathophysiology remain poorly characterized. These knowledge gaps limit our ability to identify which patients are most likely to develop this metabolic complication and design targeted prevention and treatment strategies. Therefore, we have developed a prospective, longitudinal, observational cohort study in AP, along with a series of hypothesis- driven investigations in AP-related DM. We propose The Ohio State University Clinical Center (OSU-CC), an innovative, strategically aligned, multi-disciplinary team of nationally-recognized experts to address knowledge gaps in AP-related DM and work collaboratively with other selected Clinical Centers within the framework of the NIDDK to form the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC).

项目总结/摘要 急性胰腺炎是一种常见的炎症性疾病， 后遗症急性胰腺炎发作后糖尿病的发展 （称为AP相关DM）现在在大约25%的患者中被认识到;然而， 流行病学和病理生理学的特征仍然很差。这些知识差距限制了 我们能够识别哪些患者最有可能发生这种代谢并发症， 设计有针对性的预防和治疗策略。因此，我们开发了一个 AP的前瞻性、纵向、观察性队列研究，沿着一系列假设- 在与AP相关的DM中进行驱动调查。我们建议俄亥俄州州立大学临床中心 （OSU-CC），一个创新的，战略一致的，多学科的团队，国家认可的 专家解决与AP相关的DM的知识差距，并与其他 在NIDDK框架内选定的临床中心组成1型糖尿病， 急性胰腺炎联盟（T1 DAPC）。