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The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center

俄亥俄州立大学慢性胰腺炎糖尿病胰腺癌 (CPDPC) 临床中心

基本信息

批准号：
10254411
负责人：
DARWIN LEWIS CONWELL
金额：
$ 46.29万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-28 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10254411
关键词：
Abdominal Pain Address Adult Aliquot Ancillary Study Applications Grants Artificial Intelligence Basic Science Big Data Methods Biological Biological Markers Cancer Research Infrastructure Childhood Clinical Cancer Center Clinical Sciences Clinical Trials Collaborations Collection Complement Cross-Sectional Studies Data Data Collection Development Diabetes Mellitus Digestive System Disorders Disease Enrollment Epidemiology Evaluation Exocrine pancreas Exocrine pancreatic insufficiency Fibrosis Fostering Functional disorder Funding Future Goals Grant Inflammation Infrastructure Institutes Institution Interdisciplinary Study Kidney Diseases Lead Leadership Malignant neoplasm of pancreas Malnutrition Manuscripts Medical Research National Cancer Institute Natural History Observational Study Ohio Pancreas Participant Patients Positioning Attribute Process Progress Reports Protocols documentation Publications Research Research Infrastructure Research Personnel Services Ships Tissues Universities chronic pain chronic pancreatitis clinical center diagnostic biomarker follow-up insight novel organizational structure predictive marker repository response working group

项目摘要

ABSTRACT The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.

摘要涉及胰腺外分泌疾病的机制基础还知之甚少。慢性胰腺炎通常伴有胰腺炎症、不可逆转的纤维化和胰腺的破坏。胰腺实质导致腹痛，营养不良，胰腺外分泌功能不全，胰源性糖尿病，在某些情况下，还有胰腺癌。我们已经建立了一个成人和儿科研究人员组成俄亥俄州立大学临床中心(OSU CC)。在多学科中与联盟中的其他临床中心合作研究慢性胰腺炎、糖尿病和胰腺癌临床中心(CPDPC-CCS)(U01)，OSU CC帮助制定了四(4)项主要在最初的资助周期中进行观察性研究，以弥补我们对疾病理解中的研究差距外分泌的胰腺。具体地说，OSU CC试图验证提出的诊断生物标记物在慢性胰腺炎、胰源性糖尿病和胰腺癌。