The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center

摘要 涉及胰腺外分泌疾病的机制基础还知之甚少。慢性 胰腺炎通常伴有胰腺炎症、不可逆转的纤维化和胰腺的破坏。 胰腺实质导致腹痛，营养不良，胰腺外分泌功能不全， 胰源性糖尿病，在某些情况下，还有胰腺癌。我们已经建立了一个成人和 儿科研究人员组成俄亥俄州立大学临床中心(OSU CC)。在多学科中 与联盟中的其他临床中心合作研究慢性胰腺炎、糖尿病和 胰腺癌临床中心(CPDPC-CCS)(U01)，OSU CC帮助制定了四(4)项主要 在最初的资助周期中进行观察性研究，以弥补我们对疾病理解中的研究差距 外分泌的胰腺。具体地说，OSU CC试图验证提出的诊断生物标记物在 慢性胰腺炎、胰源性糖尿病和胰腺癌。

ABSTRACT The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.