The Ohio State University Chronic Pancreatitis Diabetes Pancreas Cancer (CPDPC) Clinical Center

摘要 涉及胰腺外分泌的疾病的机制基础知之甚少。慢性 胰腺炎通常伴有胰腺炎症、不可逆的纤维化和胰腺组织的破坏。 胰腺实质导致腹痛、营养不良、胰腺外分泌功能不全， 胰源性糖尿病，在某些情况下，胰腺癌。我们建立了一个成人网络， 儿科研究者组成俄亥俄州州立大学临床中心（OSU CC）。以多学科 与慢性胰腺炎、糖尿病研究联盟中的其他临床中心合作， 胰腺癌临床中心（CPDPC-CC）（U 01），OSU CC帮助开发了四（4）个主要的 在最初的资助周期进行观察性研究，以解决我们对疾病理解的研究差距 胰腺外分泌的一部分具体而言，OSU CC旨在验证提出的诊断生物标志物， 慢性胰腺炎、胰源性糖尿病和胰腺癌。

ABSTRACT The mechanistic underpinnings of diseases involving the exocrine pancreas are poorly understood. Chronic pancreatitis is often accompanied by inflammation of the pancreas, irreversible fibrosis, and destruction of the pancreatic parenchyma resulting in abdominal pain, malnutrition, exocrine pancreatic insufficiency, pancreatogenic diabetes, and, in some cases, pancreas cancer. We have developed a network of adult and pediatric investigators to form The Ohio State University Clinical Center (OSU CC). In a multidisciplinary collaboration with other clinical centers in the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer Clinical Centers (CPDPC-CCs) (U01), the OSU CC has helped develop four (4) major observational studies during the initial funding cycle to address research gaps in our understanding of diseases of the exocrine pancreas. Specifically, the OSU CC seeks to validate proposed diagnostic biomarkers in chronic pancreatitis, pancreatogenic diabetes, and pancreas cancer.