Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus

项目摘要/摘要 摘要急性胰腺炎是一种常见的炎症性疾病，具有短期和长期的临床特点。 后遗症。急性胰腺炎发作后糖尿病的发展 (称为AP相关糖尿病)现在约有25%的患者被识别；然而，其 流行病学和病理生理学的特点仍然很差。这些知识差距限制了 我们识别哪些患者最有可能出现这种代谢并发症的能力 制定有针对性的预防和治疗策略。因此，我们开发了一种 AP的前瞻性、纵向、观察性队列研究，以及一系列假设- 推动AP相关DM的调查。我们建议俄亥俄州立大学临床中心 (OSU-CC)，一个创新的、战略一致的、多学科的团队， 解决AP相关DM中的知识缺口并与其他人协作的专家 NIDDK框架内形成1型糖尿病的部分临床中心 急性胰腺炎联盟(T1DAPC)。

Project Summary/Abstract Acute pancreatitis is a common inflammatory disorder with short- and long-term clinical sequelae. The development of diabetes mellitus following an episode of acute pancreatitis (termed AP-related DM) is now recognized in approximately 25% of patients; however, its epidemiology and pathophysiology remain poorly characterized. These knowledge gaps limit our ability to identify which patients are most likely to develop this metabolic complication and design targeted prevention and treatment strategies. Therefore, we have developed a prospective, longitudinal, observational cohort study in AP, along with a series of hypothesis- driven investigations in AP-related DM. We propose The Ohio State University Clinical Center (OSU-CC), an innovative, strategically aligned, multi-disciplinary team of nationally-recognized experts to address knowledge gaps in AP-related DM and work collaboratively with other selected Clinical Centers within the framework of the NIDDK to form the Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC).