MDIBL Symposium on Stem Cells and Aging

摘要 沙漠山生物实验室(MDIBL)，与杰克逊实验室和 缅因州医学中心研究所提议举办一系列关于“干细胞与衰老”的会议 在NIA的支持下，每年于2020年、2021年和2022年7月在MDIBL举行。这次会议建立在一个 在2002年首次举办的MDIBL上，干细胞会议有着深厚的传统。2020年的拟议系列- 2022年将聚焦于干细胞和衰老，解决与衰老相关的失败原因相关的问题 干细胞静息和激活的影响，干细胞外在机制与干细胞内在机制在 衰老相关的调节失调，以及通过稳定干细胞静止或延缓衰老的新方法 减少干细胞的脆弱性。在本次会议之后，将在MDIBL“iCARB： “沉浸在比较衰老和再生生物学”，培养研究生、博士后研究员、 和职业科学家成为衰老和再生研究的领导者。组委会，制造 由生物医学和干细胞研究领域的国家领先者组成的UP，制定了这次研讨会的计划 解决当前对干细胞和老龄化研究社区都很重要的问题。《公约》的具体目标 2020年研讨会：1)介绍和讨论影响STEM的与衰老相关的病理研究 细胞和再生，包括DNA损伤/突变、炎症、细胞代谢改变/ROS 干细胞静止的产生和衰老相关的变化；2)介绍和讨论科学进展 定义管理干细胞老化的细胞内在和外在机制，包括转录程序， 表观遗传程序、生态位细胞通讯和生态位组成；3)介绍和讨论 比较衰老方面(人、鼠、鱼、虫、蝇)，重点放在广泛保守的细胞变化上 在衰老中；4)介绍和讨论促进干细胞为基础的组织再生和年轻化的研究 衰老包括热量限制和干细胞、衰老干细胞中的炎症信号和生态位的研究 工程学；以及5)为学员、新手调查人员之间的互动提供广泛的机会 细胞研究，以及在这些研究领域有良好地位的研究人员。科学会议将包括平台 演示文稿、海报会议和实习生/教职员工网络午餐。

Abstract The Mount Desert Island Biological Laboratory (MDIBL), in collaboration with The Jackson Laboratory, and the Maine Medical Center Research Institute, proposes a conference series on "Stem Cells and Aging" to be held annually in July of 2020, 2021, and 2022 at MDIBL with the support of the NIA. This conference builds on a strong tradition of stem cell conferences at MDIBL that were first offered in 2002. The proposed series for 2020- 2022 will focus on stem cells and aging, addressing questions related to the causes of aging-associated failure of stem cell quiescence and activation, the impact of stem cell-extrinsic versus stem cell-intrinsic mechanisms in aging associated dysregulation, and new approaches to delay aging by stabilizing stem cell quiescence or reducing stem cell vulnerability. This conference will be followed by a two-week course at MDIBL "iCARB: Immersion in Comparative Aging and Regenerative Biology" that trains graduate students, postdoctoral fellows, and career scientists to become leaders in Aging and Regeneration research. The Organizing Committee, made up of national leaders in biomedical and stem cell research, has developed the program of this symposium to address current issues important to both the stem cell and aging research communities. The specific aims of the 2020 symposium are: 1) Present and discuss research studies of aging related pathologies that impact stem cells and regeneration including DNA damage / mutation, inflammation, altered cell metabolism / ROS generation, and aging-related changes in stem cell quiescence; 2) Present and discuss scientific advances defining cell-intrinsic and -extrinsic mechanisms governing stem cell aging including transcriptional programs, epigenetic programs, niche cell communication, and niche composition; 3) Present and discuss research on comparative aspects of aging (human, mouse, fish, worm, fly) with a focus on broadly conserved cellular changes in aging; 4) Present and discuss research on promoting stem cell-based tissue regeneration and rejuvenation in aging including studies of caloric restriction and stem cells, inflammatory signaling in aged stem cells, and niche engineering; and 5) Provide extensive opportunities for interaction between trainees, investigators new to stem cell research, and investigators well established in these research areas. Scientific sessions will include platform presentations, poster sessions, and a trainee/faculty networking lunch.