MDIBL Symposium on Stem Cells and Aging

摘要 沙漠山岛生物实验室（MDIBL）与杰克逊实验室合作， 缅因州医学中心研究所，提出了一个关于“干细胞和衰老”的系列会议， 在NIA的支持下，每年于2020年7月，2021年和2022年在MDIBL举行。本次会议建立在 在MDIBL的干细胞会议的强大传统，首次在2002年提供。2020年拟议的系列- 2022年将专注于干细胞和衰老，解决与衰老相关失败原因相关的问题 干细胞静止和激活的影响，干细胞-外在与干细胞-内在机制， 衰老相关的失调，以及通过稳定干细胞静止或 减少干细胞的脆弱性。本次会议之后将在MDIBL“iCARB： 沉浸在比较衰老和再生生物学”，培养研究生，博士后研究员， 和职业科学家成为衰老和再生研究的领导者。组委会，使 在生物医学和干细胞研究的国家领导人，制定了本次研讨会的计划， 解决当前对干细胞和衰老研究界都很重要的问题。的具体目标 2020年研讨会是：1）提出并讨论影响干衰老相关病理学的研究 细胞和再生，包括DNA损伤/突变、炎症、细胞代谢改变/ ROS 代，和衰老相关的变化干细胞静止; 2）目前和讨论科学进展 定义了包括转录程序在内的控制干细胞衰老的细胞内在和外在机制， 表观遗传程序，生态位细胞通讯，和生态位组成; 3）目前和讨论的研究 衰老的比较方面（人类，小鼠，鱼，蠕虫，苍蝇），重点是广泛保守的细胞变化 4）介绍和讨论促进干细胞为基础的组织再生和年轻化的研究， 衰老，包括热量限制和干细胞的研究，衰老干细胞中的炎症信号，以及小生境 5）为学员和新的科学、技术、工程和管理研究人员之间的互动提供广泛的机会 细胞研究，以及在这些研究领域建立良好的研究人员。科学会议将包括平台 演讲、海报会议和学员/教师联谊午餐。

Abstract The Mount Desert Island Biological Laboratory (MDIBL), in collaboration with The Jackson Laboratory, and the Maine Medical Center Research Institute, proposes a conference series on "Stem Cells and Aging" to be held annually in July of 2020, 2021, and 2022 at MDIBL with the support of the NIA. This conference builds on a strong tradition of stem cell conferences at MDIBL that were first offered in 2002. The proposed series for 2020- 2022 will focus on stem cells and aging, addressing questions related to the causes of aging-associated failure of stem cell quiescence and activation, the impact of stem cell-extrinsic versus stem cell-intrinsic mechanisms in aging associated dysregulation, and new approaches to delay aging by stabilizing stem cell quiescence or reducing stem cell vulnerability. This conference will be followed by a two-week course at MDIBL "iCARB: Immersion in Comparative Aging and Regenerative Biology" that trains graduate students, postdoctoral fellows, and career scientists to become leaders in Aging and Regeneration research. The Organizing Committee, made up of national leaders in biomedical and stem cell research, has developed the program of this symposium to address current issues important to both the stem cell and aging research communities. The specific aims of the 2020 symposium are: 1) Present and discuss research studies of aging related pathologies that impact stem cells and regeneration including DNA damage / mutation, inflammation, altered cell metabolism / ROS generation, and aging-related changes in stem cell quiescence; 2) Present and discuss scientific advances defining cell-intrinsic and -extrinsic mechanisms governing stem cell aging including transcriptional programs, epigenetic programs, niche cell communication, and niche composition; 3) Present and discuss research on comparative aspects of aging (human, mouse, fish, worm, fly) with a focus on broadly conserved cellular changes in aging; 4) Present and discuss research on promoting stem cell-based tissue regeneration and rejuvenation in aging including studies of caloric restriction and stem cells, inflammatory signaling in aged stem cells, and niche engineering; and 5) Provide extensive opportunities for interaction between trainees, investigators new to stem cell research, and investigators well established in these research areas. Scientific sessions will include platform presentations, poster sessions, and a trainee/faculty networking lunch.