Structure, Composition, & Histology Core - Core B

结构、组成、

基本信息

  • 批准号:
    10459375
  • 负责人:
  • 金额:
    $ 25.22万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-01 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

Michigan Integrative Musculoskeletal Health Core Center – Core B Project Summary Structure and composition across physiological length-scales are key intermediate traits that link gene expression with functional outcomes. Genetic and/or environmental perturbations affecting gene expression often lead to measureable changes in these intermediate traits that have mechanical and other functional consequences. Accurately quantifying structure and composition at different length scales is therefore essential to advancing our understanding of the molecular and mechanical mechanisms underlying musculoskeletal health and disease; to develop and evaluate treatment strategies; and to ultimately translate these strategies to the clinic. However, this research requires use of advanced and costly instruments and supporting expertise in cell biology, chemistry, engineering, and biomedical imaging. The Structure, Composition and Histology Core (Core B) will provide access to the instruments and expertise that will enable Center investigators to quantify these intermediate traits and to accelerate their research programs. Core B will include ex-vivo micro-Computed Tomography (µCT) and nano-Computed Tomography (nano-CT), Raman spectroscopy, and histology as its major components. These technologies were chosen for their applicability to all musculoskeletal tissues and based on usage data over the previous 4 years and a needs-assessment survey of core users. Investigators at the University of Michigan pioneered the use of µCT and Raman spectroscopy to investigate musculoskeletal tissues and are leaders in applying these technologies to solve musculoskeletal problems. Histology continues to be the gateway approach to understanding changes in tissue morphology and, when combined with CT and Raman spectroscopy, histology can link tissue morphology to composition and functional outcomes. The goals of this Core are to leverage the expertise of the core leadership to support the research programs of Center investigators in performing structural, compositional and histological analyses of all musculoskeletal tissues, both intellectually and financially; to expand opportunities for our research community; and to bring new investigators into the musculoskeletal community. To accomplish our goals and to continue creating a robust and sustainable impact to the musculoskeletal community in the P30 renewal application, we propose the following Specific Aims: Aim 1: To provide expertise and guidance on the best use of technologies and experimental design to allow investigators to conduct specialized assays for quantifying structure and composition across length scales. Aim 2: To provide expert use, standardization, and training in state-of-the-art technologies to quantify structure and composition across physiological length scales. Aim 3: To provide expertise and scientific guidance on data analysis, interpretation of results and recommendations for future studies. Aim 4: To expand opportunities for our research community through innovation and development of enabling technologies, education, training, and enrichment.
密歇根综合肌肉骨骼健康核心中心-核心B

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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DAVID H. KOHN其他文献

DAVID H. KOHN的其他文献

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{{ truncateString('DAVID H. KOHN', 18)}}的其他基金

Engineering anti-fragile tooth/restorative interfaces
工程防脆牙齿/修复界面
  • 批准号:
    9302392
  • 财政年份:
    2016
  • 资助金额:
    $ 25.22万
  • 项目类别:
Engineering anti-fragile tooth/restorative interfaces
工程防脆牙齿/修复界面
  • 批准号:
    9982297
  • 财政年份:
    2016
  • 资助金额:
    $ 25.22万
  • 项目类别:
Engineering anti-fragile tooth/restorative interfaces
工程防脆牙齿/修复界面
  • 批准号:
    9754109
  • 财政年份:
    2016
  • 资助金额:
    $ 25.22万
  • 项目类别:
Engineering anti-fragile tooth/restorative interfaces
工程防脆牙齿/修复界面
  • 批准号:
    9152370
  • 财政年份:
    2016
  • 资助金额:
    $ 25.22万
  • 项目类别:
Structure, Composition, & Histology Core - Core B
结构、组成、
  • 批准号:
    10676783
  • 财政年份:
    2016
  • 资助金额:
    $ 25.22万
  • 项目类别:
The Use of Erythropoietin to Reprogram Oral and Craniofacial Stem Cells
使用促红细胞生成素重新编程口腔和颅面干细胞
  • 批准号:
    7936104
  • 财政年份:
    2009
  • 资助金额:
    $ 25.22万
  • 项目类别:
The Use of Erythropoietin to Reprogram Oral and Craniofacial Stem Cells
使用促红细胞生成素重新编程口腔和颅面干细胞
  • 批准号:
    7838174
  • 财政年份:
    2009
  • 资助金额:
    $ 25.22万
  • 项目类别:
MicroCT 100
显微CT 100
  • 批准号:
    7793129
  • 财政年份:
    2009
  • 资助金额:
    $ 25.22万
  • 项目类别:
Organic /Inorganic Hybrids to Guide Bone Regeneration
引导骨再生的有机/无机混合物
  • 批准号:
    6686717
  • 财政年份:
    2003
  • 资助金额:
    $ 25.22万
  • 项目类别:
Organic/Inorganic Hybrids to Guide Bone Regeneration
引导骨再生的有机/无机混合物
  • 批准号:
    7075373
  • 财政年份:
    2003
  • 资助金额:
    $ 25.22万
  • 项目类别:

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