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MicroCT 100

显微CT 100

基本信息

批准号：
7793129
负责人：
DAVID H. KOHN
金额：
$ 38.08万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-12-31 至 2011-12-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This is a proposal to support the purchase of a Scanco CT100 specimen micro computed tomography scanner (<CT) that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry. This instrument will mainly support NIH-sponsored research in School of Dentistry as well in the College of Engineering, Medical School and College of Literature, Sciences and the Arts. The requested instrument will fulfill an unmet need for <CT at the University by providing increased throughput using an automatic sample changer, shorter scanning and reconstruction times, increased resolution and ability to analyze denser materials such as implants. Software will also be included to calculate detailed bone histomorphometric parameters and to conduct finite element analysis. Increased throughput of the instrument will reduce turnover times for sample analysis while increased resolution will allow analysis of structures in the micron range such as small blood vessels, bone microcracks and dentinal tubules. The University of Michigan has one of the highest concentrations of NIH-funded investigators in the areas of bone biology, tissue engineering and regenerative medicine, all of whom will greatly benefit from purchase of this instrument. Current, there is only a single specimen <CT on campus to support approximately 90 investigators. The CT100 will accelerate research output by providing a second high capacity instrument as well as allow new types of analysis that cannot presently be conducted on this campus. This proposal includes detailed plans for maintenance and oversight of the <CT facility, a financial plan with appropriate user fee schedules and significant long-term institutional support. PUBLIC HEALTH RELEVANCE: Three-dimensional micro-computed tomography (¿CT) has become a critically important standard technology in musculoskeletal and tissue engineering research. Use of this technology has greatly accelerated advances in the understanding of bone disease and the development of strategies for engineering functional tissues by providing quantitative measures of bone responses to physiologic, biologic, mechanical, pharmacologic or disease related influences. Since its introduction into biomedical research, this radiographic based tomographic technology, along with the development of computer reconstruction algorithms, has provided the capability to characterize bone structure as it had never been characterized before. As a result, ¿CT has had a significant impact on musculoskeletal health. This is a proposal to support the purchase of a Scanco CT100 specimen ¿CT system that is to be part of an Imaging Core Facility at the University of Michigan School of Dentistry and shared with other users in the Schools of Medicine, Engineering and Literature, Arts and Sciences. The requested instrument will fulfill an unmet need for ¿CT at the University by providing increased throughput, increased resolution and ability to analyze denser materials, enabling NIH-funded users to make further advances in health related research.

描述（由申请人提供）：这是一项支持购买 Scanco CT100 标本微型计算机断层扫描仪 (<CT) 的提案，该扫描仪将成为密歇根大学牙科学院成像核心设施的一部分。该仪器将主要支持 NIH 资助的牙科学院以及工程学院、医学院和文学、科学和艺术学院的研究。所要求的仪器将通过使用自动换样器提供更高的吞吐量、更短的扫描和重建时间、更高的分辨率以及分析植入物等致密材料的能力来满足大学对 CT 的未满足需求。还将包括用于计算详细的骨组织形态参数并进行有限元分析的软件。仪器吞吐量的增加将减少样品分析的周转时间，而分辨率的提高将允许分析微米范围的结构，例如小血管、骨微裂纹和牙本质小管。密歇根大学是骨生物学、组织工程和再生医学领域受 NIH 资助的研究人员最集中的大学之一，所有这些研究人员都将从购买该仪器中受益匪浅。目前，校园内只有一个样本 <CT 可以支持大约 90 名研究人员。 CT100 将通过提供第二台高容量仪器来加速研究成果，并允许目前无法在该园区进行的新型分析。该提案包括<CT 设施维护和监督的详细计划、具有适当用户费用表的财务计划以及重要的长期机构支持。公共健康相关性：三维微型计算机断层扫描 (¿CT) 已成为肌肉骨骼和组织工程研究中极其重要的标准技术。该技术的使用通过提供骨对生理、生物、机械、药理学或疾病相关影响的反应的定量测量，极大地加速了对骨疾病的理解和工程功能组织策略的开发。自从引入生物医学研究以来，这种基于放射线的断层扫描技术以及计算机重建算法的发展，已经提供了表征骨骼结构的能力，这是以前从未表征过的。因此，CT 对肌肉骨骼健康产生了重大影响。这是一项支持购买 Scanco CT100 标本 CT 系统的提案，该系统将成为密歇根大学牙科学院成像核心设施的一部分，并与医学院、工程与文学、艺术和科学学院的其他用户共享。所要求的仪器将通过提供更高的通量、更高的分辨率和分析更致密材料的能力来满足大学对 CT 的未满足需求，使 NIH 资助的用户能够在健康相关研究方面取得进一步进展。