Animal Model Core

动物模型核心

• 批准号: 10459260
• 负责人: MYRON E HINSDALE
• 金额: $ 17.86万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459260
• 关键词: Accreditation; Animal Experimentation; Animal Housing; Animal Model; Animal Welfare; Animals; Caring; Cities; Communicable Diseases; Ensure; Facility Accesses; Guidelines; Health Sciences; IACUC; In Vitro; Individual; Institution; Instruction; Laboratory Animals; Modeling; Occupational Health; Oklahoma; Phase; Phenotype; Policies; Procedures; Protocols documentation; Regulation; Research Activity; Research Personnel; Respiratory Center; Respiratory Disease; Scientist; Services; Training; Training Programs; Universities; Validation; Veterinarians; animal care; animal resource; experience; in vivo; member; operation; programs; respiratory; success

Animal Models Core-Abstract Each promising junior investigator (PJI) has at least limited animal research experience and needs to verify in vitro findings in vivo. As a result, consistent care, experimental procedures, and husbandry are important to the success of the projects. Therefore, the objective for the Animal Models Core (AMC) will be to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease. This will include instruction in regards to the regulations and requirements of the Institutional Animal Care and Use Committee (IACUC). The AMC will maintain an IACUC protocol for the services it provides to non-Center individuals. In addition, Dr. Hinsdale will assist the PJIs with their individual IACUC protocols. Some investigators will have to maintain approved animal use protocols at both OSU and the University of Oklahoma Health Sciences Center (OUHSC). All project leaders will be fully active in the OSU Laboratory Animal Resources (LAR) training program that includes IACUC policy training. In addition, all AMC staff and those involved in any animal procedures will participate in the OSU LAR occupational health program. The OSU LAR facility is fully AAALAC accredited and the OSU LAR care and use program satisfies the AAALAC guidelines for the composition and activity of the IACUC. The IACUC has 13 members where there are 7 scientist representatives, 2 laboratory animal veterinarian representatives, 2 veterinarian representatives, and 2 public representatives. For operation of the laboratory animal care and use program the IACUC has ultimate responsibility. These activities will convey to the PJIs, the importance of the IACUC to their research activities. Lastly, the AMC will train the PJIs on how to manage and maintain animal models. As a result of AMC operations in Phase I, the institution has upgraded state-of-the art BSL2 animal housing facilities, access to cutting edge phenotyping of respiratory models, and increased interactions between and training of OCRID researchers at OSU Stillwater, OSU Tulsa, OU Oklahoma City, OU Norman and OMRF Oklahoma City.

动物模型核心摘要 每个有前途的初级研究员（PJI）都至少有有限的动物研究经验 并需要在体内验证体外研究结果。因此，持续的护理、实验 程序和管理对于项目的成功非常重要。因此， 动物模型核心（AMC）的目标是确保项目实验 一致性、遵守联邦动物福利法规和援助 呼吸道疾病动物模型的前沿表型分析。这将 包括有关机构的法规和要求的说明 动物护理和使用委员会 (IACUC)。 AMC 将维护 IACUC 协议 它向非中心个人提供的服务。此外，Hinsdale 博士将协助 PJI 及其各自的 IACUC 协议。一些调查人员将不得不维持 俄克拉荷马州立大学和俄克拉荷马大学健康分校批准的动物使用协议 科学中心（OUHSC）。所有项目负责人都将全力活跃在 OSU 实验室 动物资源 (LAR) 培训计划，包括 IACUC 政策培训。在 此外，所有 AMC 工作人员和参与任何动物程序的人员都将参加 OSU LAR 职业健康计划。 OSU LAR 设施完全符合 AAALAC 标准 经认可且 OSU LAR 护理和使用计划满足 AAALAC 指南 IACUC 的组成和活动。 IACUC 有 13 名成员，其中 科学家代表7名、实验动物兽医代表2名、 兽医代表和 2 名公众代表。对于操作 实验动物护理和使用计划 IACUC 负有最终责任。这些 活动将向 PJI 传达 IACUC 对其研究活动的重要性。 最后，AMC 将对 PJI 进行如何管理和维护动物模型的培训。作为一个 作为 AMC 第一阶段运营的结果，该机构已升级最先进的 BSL2 动物饲养设施，获得最先进的呼吸模型表型分析，以及 增加俄勒冈州立大学斯蒂尔沃特 OCRID 研究人员之间的互动和培训， OSU 塔尔萨、OU 俄克拉荷马城、OU 诺曼和 OMRF 俄克拉荷马城。