Animal Model Core

动物模型核心

• 批准号: 10459260
• 负责人: MYRON E HINSDALE
• 金额: $ 17.86万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459260
• 关键词: Accreditation; Animal Experimentation; Animal Housing; Animal Model; Animal Welfare; Animals; Caring; Cities; Communicable Diseases; Ensure; Facility Accesses; Guidelines; Health Sciences; IACUC; In Vitro; Individual; Institution; Instruction; Laboratory Animals; Modeling; Occupational Health; Oklahoma; Phase; Phenotype; Policies; Procedures; Protocols documentation; Regulation; Research Activity; Research Personnel; Respiratory Center; Respiratory Disease; Scientist; Services; Training; Training Programs; Universities; Validation; Veterinarians; animal care; animal resource; experience; in vivo; member; operation; programs; respiratory; success

Animal Models Core-Abstract Each promising junior investigator (PJI) has at least limited animal research experience and needs to verify in vitro findings in vivo. As a result, consistent care, experimental procedures, and husbandry are important to the success of the projects. Therefore, the objective for the Animal Models Core (AMC) will be to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease. This will include instruction in regards to the regulations and requirements of the Institutional Animal Care and Use Committee (IACUC). The AMC will maintain an IACUC protocol for the services it provides to non-Center individuals. In addition, Dr. Hinsdale will assist the PJIs with their individual IACUC protocols. Some investigators will have to maintain approved animal use protocols at both OSU and the University of Oklahoma Health Sciences Center (OUHSC). All project leaders will be fully active in the OSU Laboratory Animal Resources (LAR) training program that includes IACUC policy training. In addition, all AMC staff and those involved in any animal procedures will participate in the OSU LAR occupational health program. The OSU LAR facility is fully AAALAC accredited and the OSU LAR care and use program satisfies the AAALAC guidelines for the composition and activity of the IACUC. The IACUC has 13 members where there are 7 scientist representatives, 2 laboratory animal veterinarian representatives, 2 veterinarian representatives, and 2 public representatives. For operation of the laboratory animal care and use program the IACUC has ultimate responsibility. These activities will convey to the PJIs, the importance of the IACUC to their research activities. Lastly, the AMC will train the PJIs on how to manage and maintain animal models. As a result of AMC operations in Phase I, the institution has upgraded state-of-the art BSL2 animal housing facilities, access to cutting edge phenotyping of respiratory models, and increased interactions between and training of OCRID researchers at OSU Stillwater, OSU Tulsa, OU Oklahoma City, OU Norman and OMRF Oklahoma City.

动物模型核心吸收 每个有前途的初级研究员（PJI）至少具有有限的动物研究经验 并且需要在体内验证体外发现。结果，一致的护理，实验性 程序和饲养对项目的成功很重要。因此， 动物模型核心（AMC）的目标是确保项目实验 一致性，遵守联邦动物福利法规和援助 在呼吸道疾病动物模型的尖端表型中。这会 包括有关机构规定和要求的指示 动物护理和使用委员会（IACUC）。 AMC将维护IACUC方案 它为非中心个人提供的服务。此外，欣斯代尔博士将协助 PJI及其单独的IACUC方案。一些调查人员必须维护 OSU和俄克拉荷马大学健康的批准动物使用方案 科学中心（OUHSC）。所有项目领导者将在OSU实验室中充分活跃 动物资源（LAR）培训计划，包括IACUC政策培训。在 此外，所有AMC工作人员和参与任何动物程序的人员都将参加 OSU LAR职业健康计划。 OSU LAR设施完全是Aaalac 经过认可的OSU LAR CARE and PLAGIN计划满足AAALAC的指南 IACUC的组成和活性。 IACUC有13名成员 7个科学家代表，2个实验室动物兽医代表，2 兽医代表和2名公共代表。用于操作 实验室动物护理和使用计划IACUC具有最终责任。这些 活动将传达给PJI，这是IACUC对其研究活动的重要性。 最后，AMC将培训PJI关于如何管理和维护动物模型的培训。作为 AMC运营在第一阶段的结果，该机构升级了最先进的BSL2 动物住房设施，获得呼吸模型的最前沿表型，以及 在OSU Stillwater的OSU研究人员之间的相互作用增加和培训， OSU TULSA，OU俄克拉荷马城，Ou Norman和OMRF俄克拉荷马城。