Animal Model Core

动物模型核心

• 批准号: 10459260
• 负责人: MYRON E HINSDALE
• 金额: $ 17.86万
• 依托单位: OKLAHOMA STATE UNIVERSITY STILLWATER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10459260
• 关键词: Accreditation; Animal Experimentation; Animal Housing; Animal Model; Animal Welfare; Animals; Caring; Cities; Communicable Diseases; Ensure; Facility Accesses; Guidelines; Health Sciences; IACUC; In Vitro; Individual; Institution; Instruction; Laboratory Animals; Modeling; Occupational Health; Oklahoma; Phase; Phenotype; Policies; Procedures; Protocols documentation; Regulation; Research Activity; Research Personnel; Respiratory Center; Respiratory Disease; Scientist; Services; Training; Training Programs; Universities; Validation; Veterinarians; animal care; animal resource; experience; in vivo; member; operation; programs; respiratory; success

Animal Models Core-Abstract Each promising junior investigator (PJI) has at least limited animal research experience and needs to verify in vitro findings in vivo. As a result, consistent care, experimental procedures, and husbandry are important to the success of the projects. Therefore, the objective for the Animal Models Core (AMC) will be to ensure project experimental consistency, compliance with federal animal welfare regulations, and assistance in cutting-edge phenotyping of animal models of respiratory disease. This will include instruction in regards to the regulations and requirements of the Institutional Animal Care and Use Committee (IACUC). The AMC will maintain an IACUC protocol for the services it provides to non-Center individuals. In addition, Dr. Hinsdale will assist the PJIs with their individual IACUC protocols. Some investigators will have to maintain approved animal use protocols at both OSU and the University of Oklahoma Health Sciences Center (OUHSC). All project leaders will be fully active in the OSU Laboratory Animal Resources (LAR) training program that includes IACUC policy training. In addition, all AMC staff and those involved in any animal procedures will participate in the OSU LAR occupational health program. The OSU LAR facility is fully AAALAC accredited and the OSU LAR care and use program satisfies the AAALAC guidelines for the composition and activity of the IACUC. The IACUC has 13 members where there are 7 scientist representatives, 2 laboratory animal veterinarian representatives, 2 veterinarian representatives, and 2 public representatives. For operation of the laboratory animal care and use program the IACUC has ultimate responsibility. These activities will convey to the PJIs, the importance of the IACUC to their research activities. Lastly, the AMC will train the PJIs on how to manage and maintain animal models. As a result of AMC operations in Phase I, the institution has upgraded state-of-the art BSL2 animal housing facilities, access to cutting edge phenotyping of respiratory models, and increased interactions between and training of OCRID researchers at OSU Stillwater, OSU Tulsa, OU Oklahoma City, OU Norman and OMRF Oklahoma City.

动物模型核心-摘要 每个有前途的初级研究者（PJI）至少有有限的动物研究经验 并且需要在体内验证体外发现。因此，持续的护理，实验性的 程序和管理对项目的成功至关重要。因此 动物模型核心（AMC）的目标是确保项目实验 一致性，符合联邦动物福利法规，并提供帮助 呼吸道疾病动物模型的最新表型分析。这将 包括有关机构的规定和要求的说明 动物护理和使用委员会（IACUC）。AMC将维护IACUC协议， 它提供给非中心个人的服务。此外，欣斯代尔博士将协助 PJIs及其各自的IACUC协议。一些调查人员将不得不保持 俄勒冈州立大学和俄克拉荷马州卫生大学批准的动物使用方案 科学中心（OUHSC）。所有项目负责人将在俄勒冈州立大学实验室充分发挥作用 动物资源（LAR）培训计划，包括IACUC政策培训。在 此外，所有AMC工作人员和参与任何动物程序的人员将参加 OSU LAR职业健康计划。OSU LAR设施完全是AAALAC 获得认证，OSU LAR护理和使用计划满足AAALAC指南， IACUC的组成和活动。IACUC有13个成员， 科学家代表7名，实验动物兽医代表2名， 兽医代表和2名公众代表。用于操作 IACUC对实验动物护理和使用计划负有最终责任。这些 活动将向PJIs传达IACUC对其研究活动的重要性。 最后，AMC将培训PJIs如何管理和维护动物模型。作为 由于AMC在第一阶段的运作，该机构已经升级了最先进的BSL 2 动物饲养设施，获得最先进的呼吸模型表型，以及 OSU Stillwater的OCRID研究人员之间的互动和培训增加， 俄勒冈州立大学塔尔萨，俄克拉荷马州俄克拉荷马州市，诺曼和OMRF俄克拉荷马州市。