Animal Models Core

动物模型核心 项目总结： 生物医学研究卓越中心第一阶段和第二阶段动物模型核心资助(AMC) 建立了一个研究核心，拥有呼吸道和传染病方面的专业知识，包括最先进的 设备和动物生物安全二级(ABSL-2)住房和程序设施。在第三阶段，AMC将 正在利用新的尖端动物表型鉴定设备扩大对ABSL-2研究的服务 呼吸道和传染病的模型。此外，AMC将把它的服务扩展到ABSL-3 动物模型，以更好地满足州一级和国家一级对BSL3研究的迫切需求 水平。这项第三阶段建议的中心目标是加强现有的蓝线第二期基础设施和 服务，并增强AMC的ABSL-3能力，以适应不断扩大的需求，在呼吸和 俄克拉何马州的传染病研究。这项提议的目的是：i)目标1：提供最先进的 向科布雷试点项目和其他俄克拉荷马州研究人员提供ABSL-2/3服务；ii)目标2：提供ABSL-2/3 对Cobre调查人员进行试验性和监管培训；三)目标3：制定一种可持续和 独立的ABSL-2/3 AMC，用于第三阶段资金以外的用途。作为第三阶段活动的结果，AMC 将加强俄克拉荷马州呼吸道感染中心之间的跨学科互动和培训 俄克拉何马州立大学、俄克拉何马大学和俄克拉何马医学院的疾病(OCRID)研究人员 研究基金会。

Animal Models Core Project Summary: Centers of Biomedical Research Excellence Phase I and II funding for the animal models core (AMC) established a research core with expertise in respiratory and infectious diseases, including state-of-the-art equipment and animal biosafety level 2 (ABSL-2) housing and procedural facilities. With Phase III the AMC will be expanding its services for the ABSL-2 studies with new cutting-edge equipment for phenotyping of animal models of respiratory and infectious disease. In addition, the AMC will be expanding its services to ABSL-3 animal models to better address the urgent needs for BSL3 research at the state level as well as the national level. The central objective of this Phase III proposal is to strengthen the existing BSL2 infrastructure and services and enhance the AMC with ABSL-3 capabilities to adapt to the expanding needs in respiratory and infectious disease research in Oklahoma. The aims of this proposal are: i) Aim 1: Provide a state-of-the-art ABSL-2/3 service to CoBRE pilot projects and other Oklahoma researchers; ii) Aim 2: Provide ABSL-2/3 experimental and regulatory training to CoBRE investigators; iii) Aim 3: Develop a sustainable and independent ABSL-2/3 AMC for use beyond Phase III funding. As a result of Phase III activities, the AMC will increase interdisciplinary interactions between and training of Oklahoma Center for Respiratory Infectious Disease (OCRID) researchers at Oklahoma State University, University of Oklahoma and Oklahoma Medical Research Foundation.