Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome

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Our Administrative Core was designed to support and facilitate the scientific missions of our proposed Center entitled “Translational Medicine and Mechanistic Studies of Brain Neurophysiology in Fragile X Syndrome”. This Core will provide a centralized administrative body to ensure project interrelatedness and a governance structure required for a large multi-project, multi-site Center program. Our Administrative Core will also organize our diverse advisory committees including an Internal Advisory Committee, External Advisory Committee, and a Family Advisory Council. The core will also allocate and coordinate activities of our multi- project Core Scientists in the areas of electrophysiological data analysis, translational behavioral and cognitive testing methods across species, and statistics. Providing centralized scientific resources in these areas will be invaluable to assuring the synchrony and interrelatedness among Projects, and our ability to compare their results. With input from program staff, we took the step of housing these scientific resources in this Core to ensure that their contributions are coordinated at the level of the Center by the scientific leaders comprising the Core Steering Committee to optimize achievement of our primary scientific missions. The Administrative Core will coordinate research dissemination to the FXS family community, and the sharing of research results and methods to the scientific community. Finally, our Administrative Core will coordinate and support the training of clinical and preclinical students and professionals specifically to support future generations of clinical providers and preclinical and translational researchers in the field.