Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome

脆性 X 综合征脑神经生理学的转化医学和机制研究

基本信息

批准号：
10271297
负责人：
Craig Erickson
金额：
$ 38.81万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10271297
关键词：
Accountability Achievement Address Advisory Committees Animal Experiments Animal Model Area Back Behavior Biological Markers Biology Brain Clinical Clinical Research Code Communication Communities Consultations Data Data Analyses Development Disease model Drug Monitoring Education Electrophysiology (science)Ensure FMR1 Failure Family Fostering Foundations Fragile X Syndrome Functional disorder Future Generations Goals Guidelines Heterogeneity Housing Human Human Resources IACUC Institutional Review Boards Lead Methods Mission Modeling Mus National Institute of Mental Health Neurons Neurosciences Neurosciences Research Patient Monitoring Patients Pharmaceutical Preparations Pharmacotherapy Phenotype Policies Procedures Productivity Provider Recovery Regulation Research Resource Sharing Resources Risk Rodent Scientist Services Signal Transduction Site Statistical Data Interpretation Structure Students Testing Training Support Translating Treatment outcome United States National Institutes of Health Universities Voice Work analytical tool base behavior test bench to bedside biomarker development cognitive testing data archive design drug development drug discovery effective therapy experience human study in vivo molecular modeling mouse model neurophysiology novel novel therapeutics patient biomarkers patient oriented patient oriented research patient stratification pre-clinical predictive marker programs research data dissemination statistics success support network synergism therapy development translational medicine translational scientist

项目摘要

Our Administrative Core was designed to support and facilitate the scientific missions of our proposed Center entitled “Translational Medicine and Mechanistic Studies of Brain Neurophysiology in Fragile X Syndrome”. This Core will provide a centralized administrative body to ensure project interrelatedness and a governance structure required for a large multi-project, multi-site Center program. Our Administrative Core will also organize our diverse advisory committees including an Internal Advisory Committee, External Advisory Committee, and a Family Advisory Council. The core will also allocate and coordinate activities of our multi- project Core Scientists in the areas of electrophysiological data analysis, translational behavioral and cognitive testing methods across species, and statistics. Providing centralized scientific resources in these areas will be invaluable to assuring the synchrony and interrelatedness among Projects, and our ability to compare their results. With input from program staff, we took the step of housing these scientific resources in this Core to ensure that their contributions are coordinated at the level of the Center by the scientific leaders comprising the Core Steering Committee to optimize achievement of our primary scientific missions. The Administrative Core will coordinate research dissemination to the FXS family community, and the sharing of research results and methods to the scientific community. Finally, our Administrative Core will coordinate and support the training of clinical and preclinical students and professionals specifically to support future generations of clinical providers and preclinical and translational researchers in the field.

我们的行政核心旨在支持和促进我们提议的中心的科学任务题为“脆弱X综合征中脑神经生理学的转化医学和机械研究”。该核心将提供一个集中的行政机构，以确保项目相互关联和治理大型多项目中心计划所需的结构。我们的行政核心也将组织我们的潜水员咨询委员会，包括内部咨询委员会，外部咨询委员会和家庭咨询委员会。核心还将分配和协调我们的多种多样的活动项目核心科学家在电生理数据分析，翻译行为和认知的领域跨物种和统计的测试方法。在这些领域提供的集中科学资源将是有助于确保项目之间的同步和相互关系，以及我们比较他们的能力结果。通过计划人员的意见，我们采取了将这些科学资源置于此核心的步骤确保通过完成科学领导者在中心的层面协调他们的贡献核心指导委员会优化我们的主要科学任务的实现。行政核心将协调研究向FXS家庭社区的传播，并共享研究结果和科学界的方法。最后，我们的行政核心将协调和支持培训临床和临床前的学生和专业人士专门支持子孙后代以及该领域的临床前和翻译的研究人员。