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Translational medicine and mechanistic studies of brain neurophysiology in Fragile X Syndrome

脆性 X 综合征脑神经生理学的转化医学和机制研究

基本信息

批准号：
10669016
负责人：
Craig Erickson
金额：
$ 40.03万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-25 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10669016
关键词：
Accountability Achievement Address Advisory Committees Animal Experiments Animal Model Area Back Behavior Biological Markers Biology Brain Clinical Clinical Research Code Collaborations Communication Communities Consultations Data Data Analyses Development Disease model Drug Monitoring Education Electrophysiology (science)Ensure FMR1 Failure Family Fostering Foundations Fragile X Syndrome Functional disorder Future Generations Goals Guidelines Heterogeneity Housing Human Human Resources IACUC Institutional Review Boards Learning Methods Mission Modeling Mus National Institute of Mental Health Neurons Neurosciences Neurosciences Research Patient Monitoring Patients Pharmaceutical Preparations Pharmacotherapy Phenotype Policies Procedures Productivity Provider Recovery Regulation Research Resource Sharing Resources Risk Rodent Scientist Services Shapes Signal Transduction Site Statistical Data Interpretation Structure Students Testing Training Support Translating Treatment outcome United States National Institutes of Health Universities Voice Work analytical tool behavior test bench to bedside biomarker development clinical training cognitive testing data archive design drug development drug discovery effective therapy experience human study in vivo molecular modeling mouse model neurophysiology novel novel therapeutics patient biomarkers patient oriented patient oriented research patient stratification pre-clinical predictive marker programs research data dissemination statistics success support network synergism therapy development translational medicine translational scientist

项目摘要

Our Administrative Core was designed to support and facilitate the scientific missions of our proposed Center entitled “Translational Medicine and Mechanistic Studies of Brain Neurophysiology in Fragile X Syndrome”. This Core will provide a centralized administrative body to ensure project interrelatedness and a governance structure required for a large multi-project, multi-site Center program. Our Administrative Core will also organize our diverse advisory committees including an Internal Advisory Committee, External Advisory Committee, and a Family Advisory Council. The core will also allocate and coordinate activities of our multi- project Core Scientists in the areas of electrophysiological data analysis, translational behavioral and cognitive testing methods across species, and statistics. Providing centralized scientific resources in these areas will be invaluable to assuring the synchrony and interrelatedness among Projects, and our ability to compare their results. With input from program staff, we took the step of housing these scientific resources in this Core to ensure that their contributions are coordinated at the level of the Center by the scientific leaders comprising the Core Steering Committee to optimize achievement of our primary scientific missions. The Administrative Core will coordinate research dissemination to the FXS family community, and the sharing of research results and methods to the scientific community. Finally, our Administrative Core will coordinate and support the training of clinical and preclinical students and professionals specifically to support future generations of clinical providers and preclinical and translational researchers in the field.

我们的行政核心旨在支持和促进我们拟建中心的科学任务题为“脆性X综合征的脑神经生理学的转化医学和机制研究”。该核心将提供一个集中的管理机构，以确保项目的关联性和治理大型多项目、多站点中心项目所需的结构。我们的行政核心也将组织我们的各种咨询委员会，包括内部咨询委员会、外部咨询委员会委员会和家庭咨询委员会。核心还将分配和协调我们的多- 电生理数据分析、翻译行为和认知领域的核心科学家项目跨物种的测试方法和统计。将在这些领域提供集中的科学资源对于确保项目之间的同步性和相互关联性以及我们比较其结果。在项目工作人员的投入下，我们采取了将这些科学资源存放在这个核心中的步骤确保他们的贡献在中心一级由科学领袖协调，科学领袖包括核心指导委员会，以优化我们主要科学任务的完成情况。行政核心将协调研究向FXS家庭社区的传播，并分享研究成果和方法给科学界。最后，我们的行政核心将协调和支持临床和临床前学生和专业人员，专门为未来的临床提供者提供支持以及该领域的临床前和转化型研究人员。