权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Deciphering Preserved Autonomic Function after Spinal Cord Injury

解读脊髓损伤后保留的自主功能

基本信息

批准号：
10453662
负责人：
Ryan Solinsky
金额：
$ 17.05万
依托单位：
SPAULDING REHABILITATION HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-24 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10453662
关键词：
Affect Ambulatory Monitoring Animal Model Autonomic Dysfunction Autonomic Dysreflexia Autonomic nervous system Autopsy Blood Pressure Boston Cardiovascular system Caring Catecholamines Clinical Clinical Research Clinical assessments Collaborations Complication Doctor of Philosophy Exercise Foundations Functional Magnetic Resonance Imaging Functional disorder Funding Future Galvanic Skin Response Goals Grant Health Care Costs Healthcare Home Hospitals Human Image Incidence Individual Injury Intervention Knowledge Laboratories Lead Link Maps Massachusetts Mentored Patient-Oriented Research Career Development Award Mentors Methods Motor Neuroanatomy Neurologic Neurologist Neurons Neurosciences Paralysed Pathway interactions Pattern Persons Phenotype Physical Medicine Physicians Physiological Physiology Population Population Heterogeneity Proxy Quality of life Questionnaires Recovery of Function Regulation Rehabilitation therapy Reporting Research Research Personnel Research Project Grants Research Proposals Resources Rest Role Scientist Secondary to Sensory Severities Signal Transduction Skin Temperature Spinal Cord Spinal cord injury Statistical Methods Structure Sympathetic Nervous System Symptoms System Techniques Testing Training Translating Translations Work base career career development clinical application clinical translation clinically actionable computational neuroscience cost design dorsal horn experimental study foot functional outcomes heart rate variability improved improved outcome infancy insight medical schools mortality nervous system disorder neuroimaging neuroregulation novel preservation prevent response skills smart watch spinal cord mapping stressor tool

项目摘要

Project summary/abstract: This training grant seeks funding to support the career development of Dr. Ryan Solinsky, a Physical Medicine & Rehabilitation physician-scientist at Spaulding Rehabilitation Hospital and Harvard Medical School, Boston, Massachusetts. Dr. Solinsky is establishing himself as an early career investigator in the clinical application and translation of autonomic neuroscience to improve functional outcomes for individuals after spinal cord injury. This K23 award will provide Dr. Solinsky the necessary support to accomplish the following training goals: 1) Broaden his understanding in computational neuroscience, with a focus on developing expertise in direct sympathetic nervous system recordings and spike train decoding, and in ambulatory monitoring of autonomic indicators; 2) Develop novel functional autonomic neuroimaging through collaboration with local experts 3) Grow his expertise in advanced statistical methods, appropriate for small-n studies of often heterogeneous populations such as those with spinal cord injury; and 4) Expand research project management, grantsmanship, and clinical research skills. To achieve these goals, Dr. Solinsky has developed a training plan with Dr. J. Andrew Taylor as his primary mentor. Dr. Taylor is a well-respected PhD scientist, with research expertise in autonomic control of the cardiovascular system as well as how this system is affected by exercise, specifically in individuals with spinal cord injury. Dr. Solinsky will have additional co-mentors: Dr. Teresa Kimberley, PT, PhD whose research focuses on translation of autonomic neuromodulation to improve outcomes after neurologic disease, and Dr. Roy Freeman, MBChB, a Neurologist and researcher specializing in clinical assessments of autonomic dysfunction. Further collaborators with expertise in functional neuroimaging, advanced statistical methods, and clinical spinal cord injury care are included in this proposal, which will be headquartered at Spaulding Rehabilitation Hospital in Boston, Massachusetts. Autonomic dysfunction following spinal cord injury is a significant clinical issue contributing to mortality and increased healthcare costs. Unfortunately, our understanding of autonomic dysfunction in this population is in its infancy. The overall objective of this research proposal is to characterize cardiovascular autonomic dysfunction after spinal cord injury using a battery of laboratory, ambulatory, and imaging-based tools. These will be focused on cardiovascular autonomic function, as this has the highest potential for clinical translation, with correlative structures to other components of the autonomic nervous system investigated. Research will specifically look to answer two questions: 1) Can discrete cardiovascular autonomic phenotypes be identified within those with spinal cord injury and correlated to clinical secondary autonomic complications? 2) Do those with the most dysregulated cardiovascular autonomic phenotypes demonstrate the highest rates of aberrant spinal cord functional connectivity on fMRI? Answering these questions will help us understand how autonomic regulation changes after spinal cord injury and how alterations translate to clinical secondary complications.

项目总结/文摘: