Identifying Early Intervention Targets for Reducing Cardiovascular Risk in Posttraumatic Stress

确定降低创伤后应激中心血管风险的早期干预目标

• 批准号: 10453467
• 负责人: Jennifer A Sumner
• 金额: $ 74.14万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453467
• 关键词: Adult; Atherosclerosis; Attention; Autonomic nervous system; Biological; Cardiotoxicity; Cardiovascular Diseases; Cardiovascular Physiology; Cause of Death; Communities; Complex; Diagnosis; Dimensions; Disease Surveillance; Early Intervention; Emotions; Endothelial Cells; Endothelium; Event; Exposure to; Extinction (Psychology); Fright; Functional disorder; Future; Galvanic Skin Response; Goals; Health; Impairment; Individual; Inflammation; Intervention; Interview; Knowledge; Link; Measurement; Measures; Mediating; Mental disorders; Modeling; Numbness; Oxidative Stress; Participant; Pathologic; Police officer; Population; Post-Traumatic Stress Disorders; Psychophysiology; Public Health; Recording of previous events; Risk; Risk Factors; Role; Sampling; Stimulus; Stress; Symptoms; Testing; Trauma; United States; Vasodilation; Veterans; Woman; Work; associated symptom; attentional bias; base; cardiovascular disorder risk; cardiovascular risk factor; cell injury; conditioned fear; conditioning; dysphoria; endothelial dysfunction; experience; follow-up; male; men; mortality; population based; post-traumatic stress; prospective; response; stress related disorder; trauma exposure; traumatic event; treatment trial

PROJECT SUMMARY Posttraumatic stress disorder (PTSD) increases risk of incident cardiovascular disease (CVD) by 25-50%. Most individuals (50-90%) experience a traumatic event in their lifetime, and PTSD is the fifth most common psychiatric disorder. Experts have now called for increased CVD surveillance after trauma and for PTSD treatment trials powered to reduce CVD risk. However, both CVD risk and PTSD are complex phenomena that likely interact in nuanced ways. Therefore, for such efforts to be successful, we must first identify the mechanisms by which PTSD influences incident CVD risk. Further, we must understand which of the dimensions underlying PTSD activate those CVD risk mechanisms. This study will determine which PTSD dimension(s) contribute to endothelial dysfunction, one of the earliest modifiable precursors to CVD. Only three studies in select trauma-exposed populations (male veterans and police officers) have tested the association of PTSD symptoms with flow-mediated dilation (FMD), a functional measure of endothelial dysfunction. This early work points to endothelial dysfunction as a potential mechanism of the PTSD-CVD link, but the limited generalizability and lack of nuanced measurement of both posttraumatic stress and endothelial dysfunction in those studies has limited their impact. Indeed, we still do not know whether PTSD and endothelial dysfunction are associated in individuals from the broader community. Knowledge of which aspects of PTSD are most “cardiotoxic” is also lacking, so we do not know which posttraumatic stress dimensions to target. Fear responses are a core component of PTSD with direct biological relevance to cardiovascular function, whereas the dysphoria dimension of PTSD is considered more auxiliary. In this study, we will examine cross-sectional and longitudinal associations of PTSD and its underlying dimensions with functional and, secondarily, cellular measures of endothelial dysfunction (FMD and circulating endothelial cell-derived microparticles, respectively) in a community-dwelling sample of CVD-free adult men and women with a history of trauma (50% with current PTSD). In Primary Aim 1, we will test the association of PTSD diagnosis with endothelial dysfunction. In Primary Aim 2, we will examine which PTSD dimensions (objective measures of fear and dysphoria, as well as interview-assessed lower-order symptom dimensions) are most strongly associated with endothelial dysfunction. In a Secondary Aim, we will examine how these PTSD dimensions predict change in endothelial dysfunction over 2 years in a subset of the sample. Finally, we will explore the role of stress-related biological mechanisms, including autonomic imbalance, inflammation, and oxidative stress, in the associations of PTSD dimensions with endothelial dysfunction. This study will provide the strongest evidence to date for a biologically plausible mechanistic model of PTSD’s influence on incident CVD risk. If our hypotheses are supported, future interventions will be optimized to reduce posttraumatic fear or another PTSD dimension so as to reduce early endothelial damage and offset CVD risk, making CVD surveillance and intervention after trauma worthwhile.

PROJECT SUMMARY Posttraumatic stress disorder (PTSD) increases risk of incident cardiovascular disease (CVD) by 25-50%. Most individuals (50-90%) experience a traumatic event in their lifetime, and PTSD is the fifth most common psychiatric disorder. Experts have now called for increased CVD surveillance after trauma and for PTSD treatment trials powered to reduce CVD risk. However, both CVD risk and PTSD are complex phenomena that likely interact in nuanced ways. Therefore, for such efforts to be successful, we must first identify the mechanisms by which PTSD influences incident CVD risk. Further, we must understand which of the dimensions underlying PTSD activate those CVD risk mechanisms. This study will determine which PTSD dimension(s) contribute to endothelial dysfunction, one of the earliest modifiable precursors to CVD. Only three studies in select trauma-exposed populations (male veterans and police officers) have tested the association of PTSD symptoms with flow-mediated dilation (FMD), a functional measure of endothelial dysfunction. This early work points to endothelial dysfunction as a potential mechanism of the PTSD-CVD link, but the limited generalizability and lack of nuanced measurement of both posttraumatic stress and endothelial dysfunction in those studies has limited their impact. Indeed, we still do not know whether PTSD and endothelial dysfunction are associated in individuals from the broader community. Knowledge of which aspects of PTSD are most “cardiotoxic” is also lacking, so we do not know which posttraumatic stress dimensions to target. Fear responses are a core component of PTSD with direct biological relevance to cardiovascular function, whereas the dysphoria dimension of PTSD is considered more auxiliary. In this study, we will examine cross-sectional and longitudinal associations of PTSD and its underlying dimensions with functional and, secondarily, cellular measures of endothelial dysfunction (FMD and circulating endothelial cell-derived microparticles, respectively) in a community-dwelling sample of CVD-free adult men and women with a history of trauma (50% with current PTSD). In Primary Aim 1, we will test the association of PTSD diagnosis with endothelial dysfunction. In Primary Aim 2, we will examine which PTSD dimensions (objective measures of fear and dysphoria, as well as interview-assessed lower-order symptom dimensions) are most strongly associated with endothelial dysfunction. In a Secondary Aim, we will examine how these PTSD dimensions predict change in endothelial dysfunction over 2 years in a subset of the sample. Finally, we will explore the role of stress-related biological mechanisms, including autonomic imbalance, inflammation, and oxidative stress, in the associations of PTSD dimensions with endothelial dysfunction. This study will provide the strongest evidence to date for a biologically plausible mechanistic model of PTSD’s influence on incident CVD risk. If our hypotheses are supported, future interventions will be optimized to reduce posttraumatic fear or another PTSD dimension so as to reduce early endothelial damage and offset CVD risk, making CVD surveillance and intervention after trauma worthwhile.

项目成果

Stressful life events and accelerated biological aging over time in youths.

• DOI: 10.1016/j.psyneuen.2023.106058
• 发表时间: 2023-05
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Sumner, Jennifer A.;Gao, Xu;Gambazza, Simone;Dye, Christian K.;Colich, Natalie L.;Baccarelli, Andrea A.;Uddin, Monica;McLaughlin, Katie A.
• 通讯作者: McLaughlin, Katie A.

Posttraumatic stress disorder (PTSD), sleep, and cardiovascular disease risk: A mechanism-focused narrative review.

• DOI: 10.1037/hea0001143
• 发表时间: 2022-10
• 期刊: HEALTH PSYCHOLOGY
• 影响因子: 4.2
• 作者: Meinhausen, Corinne;Prather, Aric A.;Sumner, Jennifer A.
• 通讯作者: Sumner, Jennifer A.

Understanding trajectories of underlying dimensions of posttraumatic psychopathology.

• DOI: 10.1016/j.jad.2021.01.086
• 发表时间: 2021-04-01
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Sumner JA;Rünger D;Robles TF;Lowe SR;Elashoff D;Shetty V
• 通讯作者: Shetty V

Psychological and biological mechanisms linking trauma with cardiovascular disease risk.

• DOI: 10.1038/s41398-023-02330-8
• 发表时间: 2023-01-27
• 期刊: TRANSLATIONAL PSYCHIATRY
• 影响因子: 6.8
• 作者: Sumner, Jennifer A.;Cleveland, Shiloh;Chen, Tiffany;Gradus, Jaimie L.
• 通讯作者: Gradus, Jaimie L.

Key dimensions of post-traumatic stress disorder and endothelial dysfunction: a protocol for a mechanism-focused cohort study.

• DOI: 10.1136/bmjopen-2020-043060
• 发表时间: 2021-05-05
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Cleveland S;Reed K;Thomas JL;Ajijola OA;Ebrahimi R;Hsiai T;Lazarov A;Montoya AK;Neria Y;Shimbo D;Wolitzky-Taylor K;Sumner JA
• 通讯作者: Sumner JA