Overgeneral autobiographical memory: Genetic mechanisms and contributing factors

过度笼统的自传体记忆：遗传机制和影响因素

• 批准号: 8060427
• 负责人: Jennifer A Sumner
• 金额: $ 3.61万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8060427
• 关键词: Address; Anxiety; Behavior; Behavioral; Biological; Biological Markers; Brain-Derived Neurotrophic Factor; Candidate Disease Gene; Chicago; Clinical Treatment; Cognition; Cognitive; Consultations; Controlled Study; Corticotropin-Releasing Hormone Receptors; DNA; Data; Data Analyses; Depressive disorder; Development; Disease; Educational workshop; Emotional disorder; Emotions; Environment; Equation; Etiology; Foundations; Funding; Future; Genes; Genetic; Genotype; Human; Impairment; Intervention; Investigation; Knowledge; Link; Literature; Los Angeles; Maintenance; Measures; Memory; Mental Depression; Modeling; Molecular Biology; Molecular Genetics; Mood Disorders; Neuropsychology; Pathway interactions; Phenotype; Play; Problem Solving; Prospective Studies; Recording of previous events; Recruitment Activity; Research; Risk; Risk Factors; Role; Sodium Channel; Stress; Testing; Theoretical model; Training Activity; Translating; Translations; Trauma; Work; Youth; coping; eleventh grade; executive function; experience; genetic risk factor; high school; insight; memory process; psychologic; public health relevance; serotonin transporter; statistics; suburb; theories; trait; voltage

DESCRIPTION (provided by applicant): Overgeneral autobiographical memory (OGM) has emerged as an important phenomenon for understanding the etiology, phenomenology, and course of depression, and it indeed may represent a vulnerability factor for the onset and course of depression. However, knowledge is lacking about certain factors that influence OGM. Specifically, major questions remain unresolved regarding 1) the mechanisms that contribute to OGM and how they may interact, and 2) the possible molecular genetic influences on OGM and their pathways. Furthermore, the extent to which the mechanisms underlying OGM impact depression, either independently or through their effect on OGM, is unknown. This proposal aims to address these issues using data from an ongoing 8-year longitudinal prospective study of risk factors for anxiety and unipolar mood disorders. Although an examination of the mechanisms underlying OGM was not an aim of the larger investigation, measures of the proposed mechanisms are being administered for other reasons, and DNA is being collected. The proposed study will conduct an empirical test of the recent CaR-FA-X model that presents three mechanisms that may underlie OGM: capture and rumination, functional avoidance, and impaired executive control (Williams et al., 2007). Structural equation modeling (SEM) will be used to investigate the degree to which these proposed mechanisms contribute to both OGM (alone and in interaction) and depression (both directly and indirectly through their effect on OGM). Furthermore, the relationship between OGM and several candidate genes selected for their theoretical relevance to depression and memory processes will be investigated. If significant associations are detected, then SEM will be used to examine how the relevant genes may relate to the mechanisms of the CaR-FA-X model. Training activities include 1) the completion of course work in genetics, SEM, human memory and cognition, and human neuropsychology, 2) participation in summer workshops on SEM, molecular biology, and biomarker research, and 3) consultation with experts in the fields of OGM research, statistics, and genetics. These experiences will provide a strong foundation for the completion of both the proposed project and future cross-cutting research on risk factors for depression. The proposed research will provide empirical evidence that can inform current theoretical models and subsequent studies of this proposed risk factor for depression. The findings may also have implications for the clinical treatment of depression, as knowledge of the mechanisms that underlie OGM, and their effects on depression, could inform interventions. In addition, research on the relationship between OGM and genetic risk factors may increase understanding of how genes confer liability to depression, and further develop existing integrative profiles of biological and behavioral indicators of depression. PUBLIC HEALTH RELEVANCE: An empirical investigation of the mechanisms of overgeneral autobiographical memory (OGM) may have important implications for the study and treatment of depression. Greater knowledge of the biological and behavioral markers underlying OGM-a proposed risk factor for depression-has implications for understanding the etiology and course of depression. Additionally, such knowledge may inform existing treatments for depression by identifying additional targets for intervention.

描述（申请人提供）：过度概括自传体记忆（OGM）已成为理解抑郁症病因、现象学和病程的重要现象，它确实可能代表抑郁症发病和病程的脆弱性因素。然而，知识是缺乏某些因素影响OGM。具体而言，主要问题仍然没有解决，1）有助于OGM的机制以及它们如何相互作用，以及2）对OGM及其途径可能的分子遗传影响。此外，OGM影响抑郁的机制，无论是独立的还是通过对OGM的影响，都是未知的。该提案旨在利用一项正在进行的关于焦虑和单相情绪障碍风险因素的8年纵向前瞻性研究的数据来解决这些问题。虽然审查OGM背后的机制不是更大调查的目的，但出于其他原因，正在管理拟议机制的措施，并正在收集DNA。拟议的研究将对最近的CaR-FA-X模型进行实证检验，该模型提出了可能构成OGM的三种机制：捕获和反刍、功能性回避和执行控制受损（威廉姆斯等人，2007年）。结构方程模型（SEM）将用于研究这些机制在多大程度上有助于OGM（单独和相互作用）和抑郁症（直接和间接通过其对OGM的影响）。此外，OGM和几个候选基因之间的关系，选择其理论相关的抑郁症和记忆过程将进行调查。如果检测到显著关联，则SEM将用于检查相关基因如何与CaR-FA-X模型的机制相关。培训活动包括1）完成遗传学，SEM，人类记忆和认知以及人类神经心理学的课程，2）参加SEM，分子生物学和生物标志物研究的夏季研讨会，以及3）与OGM研究，统计学和遗传学领域的专家进行咨询。这些经验将为完成拟议项目和未来关于抑郁症风险因素的跨领域研究奠定坚实的基础。拟议的研究将提供经验证据，可以为当前的理论模型和随后的抑郁症风险因素研究提供信息。这些发现也可能对抑郁症的临床治疗产生影响，因为了解OGM的机制及其对抑郁症的影响可以为干预措施提供信息。此外，对OGM和遗传风险因素之间关系的研究可能会增加对基因如何赋予抑郁症易感性的理解，并进一步发展现有的抑郁症生物和行为指标的综合概况。 公共卫生关系：对过度概括自传体记忆（OGM）机制的实证研究可能对抑郁症的研究和治疗具有重要意义。更多地了解OGM的生物学和行为学标志物--抑郁症的一个危险因素--对理解抑郁症的病因和病程有意义。此外，这些知识可以通过确定额外的干预目标来为现有的抑郁症治疗提供信息。