Overgeneral autobiographical memory: Genetic mechanisms and contributing factors

过度笼统的自传体记忆：遗传机制和影响因素

• 批准号: 8193991
• 负责人: Jennifer A Sumner
• 金额: $ 2.8万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8193991
• 关键词: Address; Anxiety; Behavior; Behavioral; Biological; Biological Markers; Brain-Derived Neurotrophic Factor; Candidate Disease Gene; Chicago; Clinical Treatment; Cognition; Cognitive; Consultations; Controlled Study; Corticotropin-Releasing Hormone Receptors; DNA; Data; Data Analyses; Depressive disorder; Development; Disease; Educational workshop; Emotional disorder; Emotions; Environment; Equation; Etiology; Foundations; Funding; Future; Genes; Genetic; Genotype; Human; Impairment; Intervention; Investigation; Knowledge; Link; Literature; Los Angeles; Maintenance; Measures; Memory; Mental Depression; Modeling; Molecular Biology; Molecular Genetics; Mood Disorders; National Institute of Mental Health; Neuropsychology; Pathway interactions; Phenotype; Play; Problem Solving; Prospective Studies; Recording of previous events; Recruitment Activity; Research; Risk; Risk Factors; Role; Sodium Channel; Stress; Testing; Theoretical model; Training Activity; Translating; Translations; Trauma; Work; Youth; coping; eleventh grade; executive function; experience; genetic risk factor; high school; insight; memory process; psychologic; public health relevance; serotonin transporter; statistics; suburb; theories; trait; voltage

DESCRIPTION (provided by applicant): Overgeneral autobiographical memory (OGM) has emerged as an important phenomenon for understanding the etiology, phenomenology, and course of depression, and it indeed may represent a vulnerability factor for the onset and course of depression. However, knowledge is lacking about certain factors that influence OGM. Specifically, major questions remain unresolved regarding 1) the mechanisms that contribute to OGM and how they may interact, and 2) the possible molecular genetic influences on OGM and their pathways. Furthermore, the extent to which the mechanisms underlying OGM impact depression, either independently or through their effect on OGM, is unknown. This proposal aims to address these issues using data from an ongoing 8-year longitudinal prospective study of risk factors for anxiety and unipolar mood disorders. Although an examination of the mechanisms underlying OGM was not an aim of the larger investigation, measures of the proposed mechanisms are being administered for other reasons, and DNA is being collected. The proposed study will conduct an empirical test of the recent CaR-FA-X model that presents three mechanisms that may underlie OGM: capture and rumination, functional avoidance, and impaired executive control (Williams et al., 2007). Structural equation modeling (SEM) will be used to investigate the degree to which these proposed mechanisms contribute to both OGM (alone and in interaction) and depression (both directly and indirectly through their effect on OGM). Furthermore, the relationship between OGM and several candidate genes selected for their theoretical relevance to depression and memory processes will be investigated. If significant associations are detected, then SEM will be used to examine how the relevant genes may relate to the mechanisms of the CaR-FA-X model. Training activities include 1) the completion of course work in genetics, SEM, human memory and cognition, and human neuropsychology, 2) participation in summer workshops on SEM, molecular biology, and biomarker research, and 3) consultation with experts in the fields of OGM research, statistics, and genetics. These experiences will provide a strong foundation for the completion of both the proposed project and future cross-cutting research on risk factors for depression. The proposed research will provide empirical evidence that can inform current theoretical models and subsequent studies of this proposed risk factor for depression. The findings may also have implications for the clinical treatment of depression, as knowledge of the mechanisms that underlie OGM, and their effects on depression, could inform interventions. In addition, research on the relationship between OGM and genetic risk factors may increase understanding of how genes confer liability to depression, and further develop existing integrative profiles of biological and behavioral indicators of depression. PUBLIC HEALTH RELEVANCE: An empirical investigation of the mechanisms of overgeneral autobiographical memory (OGM) may have important implications for the study and treatment of depression. Greater knowledge of the biological and behavioral markers underlying OGM-a proposed risk factor for depression-has implications for understanding the etiology and course of depression. Additionally, such knowledge may inform existing treatments for depression by identifying additional targets for intervention.

描述(申请人提供)：过度一般性的自传体记忆(OGM)已经成为了解抑郁症的病因、现象学和病程的重要现象，它确实可能代表抑郁症的发病和病程的易感性因素。然而，对影响OGM的某些因素缺乏了解。具体地说，关于1)OGM的形成机制及其相互作用，以及2)OGM可能的分子遗传影响及其途径，主要问题仍未解决。此外，OGM背后的机制对抑郁的影响程度尚不清楚，无论是独立地还是通过它们对OGM的影响。这项建议旨在利用正在进行的一项为期8年的焦虑和单相情绪障碍风险因素纵向前瞻性研究的数据来解决这些问题。尽管对OGM背后的机制的审查不是更大规模调查的目的，但出于其他原因，正在实施拟议机制的措施，并正在收集DNA。拟议的研究将对最近的CAR-FA-X模型进行实证测试，该模型提出了可能构成OGM的三种机制：捕获和沉思、功能回避和执行控制受损(Williams等人，2007年)。结构方程模型将被用来调查这些提出的机制对OGM(单独和交互作用)和抑郁症(直接和间接通过它们对OGM的影响)的贡献程度。此外，还将研究OGM和几个候选基因之间的关系，这些候选基因与抑郁症和记忆过程有理论上的相关性。如果检测到显著的关联，则将使用扫描电子显微镜来检查相关基因可能如何与CAR-FA-X模型的机制相关。培训活动包括1)完成遗传学、扫描电子显微镜、人类记忆和认知以及人类神经心理学的课程工作，2)参加关于扫描电子显微镜、分子生物学和生物标记物研究的暑期研讨会，以及3)咨询OGM研究、统计学和遗传学领域的专家。这些经验将为完成拟议的项目和未来关于抑郁症风险因素的交叉研究提供坚实的基础。这项拟议的研究将提供经验证据，为当前的理论模型和后续关于这一拟议的抑郁症危险因素的研究提供参考。这些发现也可能对抑郁症的临床治疗产生影响，因为对OGM背后的机制及其对抑郁症的影响的知识可以为干预措施提供信息。此外，研究OGM和遗传风险因素之间的关系可能会增加对基因如何赋予抑郁症易感性的理解，并进一步发展现有的抑郁症生物学和行为指标的综合概况。 公共卫生相关性：对过度泛化的自传体记忆(OGM)机制的经验性调查可能对抑郁症的研究和治疗具有重要意义。更多地了解OGM背后的生物和行为标记物--一种被认为是抑郁症的危险因素--对于理解抑郁症的病因和病程具有重要意义。此外，这些知识可能会通过确定其他干预目标来指导现有的抑郁症治疗方法。

项目成果

Specificity in autobiographical memory narratives correlates with performance on the autobiographical memory test and prospectively predicts depressive symptoms.

自传体记忆叙述的特异性与自传体记忆测试的表现相关，并前瞻性地预测抑郁症状。

• DOI: 10.1080/09658211.2012.746372
• 发表时间: 2013
• 期刊: Memory (Hove, England)
• 作者: Sumner,JenniferA;Mineka,Susan;McAdams,DanP
• 通讯作者: McAdams,DanP

The mechanisms underlying overgeneral autobiographical memory: an evaluative review of evidence for the CaR-FA-X model.

• DOI: 10.1016/j.cpr.2011.10.003
• 发表时间: 2012-02
• 期刊: CLINICAL PSYCHOLOGY REVIEW
• 影响因子: 12.8
• 作者: Sumner, Jennifer A.