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Laboratory Animal Shared Resource

实验动物共享资源

基本信息

批准号：
10641717
负责人：
Sandra Sexton
金额：
$ 25.35万
依托单位：
ROSWELL PARK CANCER INSTITUTE CORP
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-06-16 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10641717
关键词：
Accreditation Adopted Animal Cancer Model Animal Care and Use Committees Animal Experimentation Animal Husbandry Animal Model Animals Basic Science Biomedical Research Biostatistics Shared Resource Cancer Center Cancer Center Support Grant Cancer Research Project Canis familiaris Caring Clinical Investigator Clinical Trials Complex Continuing Education Data Dedications Diagnostic Ensure Environment Equipment Equipment and supply inventories Experimental Designs Faculty Family suidae Fostering Funding Future Goals Gold Grant Health Housing Human Immunologic Deficiency Syndromes In Vitro Institution International Joints Laboratory Animal Shared Resource Laboratory Animals Leadership Maintenance Manuscripts Medical Medical Research Methods Mission Modeling Operative Surgical Procedures Oryctolagus cuniculus Peer Review Preclinical Testing Procedures Production Protocols documentation Reporting Research Research Personnel Research Project Grants Resource Sharing Resources Rodent Science Scientist Services Site System Teacher Professional Development Technology Toxicology Training Training Programs Translational Research Validation Woodchuck Writing animal care cancer cell clinical application clinical practice design experimental study follow-up high standard in vivo innovation irradiation laboratory facility meetings member novel pathogen pre-clinical programs recruit sound square foot success synergism translational research program

项目摘要

The mission of the Laboratory Animal Shared Resource (LASR) is to promote the humane care and use of laboratory animals in support of basic and translational research conducted at Roswell Park. The facilities and veterinary program are both accredited by AAALAC International demonstrating the commitment to humane and responsible animal research and dedication to good science. LASR is designed to offer the highest standards of animal care, with an expert technical staff performing all aspects of daily health observations, veterinary medical care, facility and equipment maintenance and surgical and technical services. The LASR offers CCSG members a full spectrum of laboratory animal care and use services including barrier facilities with fully automated environmental controls for the housing of research animal models. The LASR provides veterinary medical care, animal health surveillance, diagnostic laboratory facilities, irradiation services, research technical services and faculty training in support of more than 200 Institute Animal Care and Use Committee-approved animal use protocols and specialized animal husbandry with trained staff that performs all husbandry manipulations during cage changing inside Bio-Safety cabinets for maintenance of a pathogen- free environment of animals held in micro isolation (MI) caging systems. The main site is a four-story ~50,000 net square feet (nsf) vivarium, which opened in 1998, located in the Medical Research Complex building. An additional 9,000 nsf is available in the adjacent Cancer Cell Center building. The animal inventory fluctuates between 39,000 to 42,000 animals housed in the facility. In the reporting period (2013-2017), the LASR served a total of 129 Roswell users, of which 106 (82%) were CCSG members. LASR supports scientists that conduct in vivo studies. To further the success of the research programs within the cancer center, the LASR is actively involved in refinement of procedures that usually become new methods or innovations to accomplish the goals of proposed animal studies. The Specific Aims of the LASR are: 1) To provide Roswell Park CCSG members access to state-of-the-art facilities, specialized husbandry and veterinary services for the housing and care of their laboratory animals used in research; 2) To propel the transition from basic and translational in vitro research into clinical application and practice using in vivo animal models of cancer; 3) To provide intellectual and technical support to assist basic and clinical investigators in all CCSG programs during experimental design, execution of projects and manuscript and/or grant writing. The goal of the LASR is to support biomedical research at the cancer center while maintaining the highest standards for the humane care and use of the laboratory animals. LASR will continue to maintain the AAALAC International accreditation for assurance of gold standards of animal care.

实验动物共享资源（LASR）的使命是促进对实验动物的人道关怀和使用实验动物支持在罗斯威尔公园进行的基础和转化研究。设施和兽医计划均获得 AAALAC International 认证，体现了对人道的承诺负责任的动物研究和对良好科学的奉献。 LASR 旨在提供最高的动物护理标准，由专家技术人员进行日常健康观察的各个方面，兽医医疗护理、设施和设备维护以及外科和技术服务。激光雷达为 CCSG 成员提供全方位的实验动物护理和使用服务，包括屏障设施为研究动物模型的饲养提供全自动环境控制。 LASR 提供兽医医疗、动物健康监测、诊断实验室设施、辐照服务、为 200 多个动物护理和使用研究所提供支持的研究技术服务和师资培训委员会批准的动物使用协议和专门的畜牧业以及训练有素的工作人员在生物安全柜内更换笼子期间进行的所有饲养操作，以维持病原体- 微隔离（MI）笼养系统中动物的自由环境。主场地为四层~50,000 净平方英尺 (nsf) 动物园于 1998 年开业，位于医学研究综合大楼内。一个邻近的癌症细胞中心大楼还提供 9,000 nsf 的额外空间。动物库存波动该设施内饲养着 39,000 至 42,000 只动物。报告期内（2013年-2017年），LASR服务了共有 129 位 Roswell 用户，其中 106 位（82%）是 CCSG 会员。 LASR 支持科学家进行体内研究。为了促进癌症中心研究项目的成功，LASR 正在积极涉及程序的细化，这些程序通常成为实现目标的新方法或创新拟议的动物研究。 LASR 的具体目标是： 1) 为罗斯威尔公园 CCSG 成员提供服务获得最先进的设施、专门的畜牧业和兽医服务，以提供住房和照顾他们用于研究的实验动物； 2）推动体外基础实验和转化实验的转变使用癌症动物模型进行临床应用和实践研究； 3）提供智力和技术支持，以在实验期间协助所有 CCSG 项目的基础和临床研究人员设计、项目执行和手稿和/或资助写作。 LASR 的目标是支持癌症中心的生物医学研究，同时保持人性化护理和使用的最高标准的实验动物。 LASR 将继续维持 AAALAC 国际认证认证动物护理的黄金标准。