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Iowa Cochlear Implant Clinical Research Center VIII

爱荷华州人工耳蜗临床研究中心 VIII

基本信息

批准号：
10640676
负责人：
Bruce Jay Gantz
金额：
$ 278.21万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-09-15 至 2028-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10640676
关键词：
Accent Acoustic Nerve Acoustics Age Attention Auditory Auditory system Bilateral Binaural Brain Characteristics Clinical Research Cochlear Implants Cochlear Nerve Cognition Cognitive Communication Compensation Cues Data Devices Ear Ecology Electrodes Environment Frequencies Funding Genetic Variation Grant Grouping Hearing Hearing Aids Human Individual Investigation Iowa Life Managed Care Medical Modality Noise Outcome Patients Perception Performance Peripheral Persons Population Predictive Factor Principal Investigator Process Quality of life Registries Rehabilitation therapy Research Research Project Grants Residual state Robotics Sensorineural Hearing Loss Short-Term Memory Side Signal Transduction Social Interaction Socialization Speech Speech Perception Steroids Structure Transcend Uncertainty Work cognitive capacity cognitive function cognitive process cognitive system cohort deafness demographics executive function face mask flexibility hearing impairment implantation improved information processing insight language processing lexical processing outcome prediction patient registry predictive modeling preservation programs psychosocial wellbeing speech in noise standard of care success

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Gantz, Bruce J. PROJECT SUMMARY - OVERVIEW Cochlear implants (CI) have become the standard of care for managing profound sensorineural hearing loss. These devices provide significant improvement in word understanding in quiet but have limitations in noisy backgrounds. Difficulty understanding speech perception in noise (SiN) in real-world environments is one of the most common complaints of people with any type of hearing impairment who are seeking hearing rehabilitation. We believe that the ability to understand SiN is a product of the auditory periphery as well as plasticity afforded by cortical and cognitive processes. At the level of cortical and cognitive processing, our prior work has identified a suite of cognitive mechanisms, including figure/ground separation and changes in lexical processing that interact with the signal quality to impact SiN outcomes. Upon this progress, we now must expand investigations to better understand the influence of other important factors, such as higher order cognitive processes (e.g., working memory and executive functioning), with high potential to assist improvement in SiN abilities among individuals with hearing loss. Furthermore, understanding the effect of these abilities on communication and socialization in real-world settings and its influence on psychosocial well- being could have long-term impact on cognitive stability. This grant incorporates a multi-pronged approach to parse the critical issues at all auditory system levels and as it relates to understanding in real-world listening. Through utilization of a variety of CI users (e.g., SSD, Bilateral, A+E), we can expand our understanding of: 1) mechanisms involved in loss of residual acoustic hearing and how those can facilitate better preservation outcomes; 2) how listeners adapt to and fuse the A+E information to improve hearing in real-world challenging situations; and 3) whether an individual’s cognitive functioning assist the integration of A+E processing. Furthermore, we recognize that communication difficulties transcend SiN performance; we will investigate mechanisms involved with listening in rapid, quiet, or accented speech, reverberant environments, and missing cues (e.g., wearing face masks). The Iowa Cochlear Implant Clinical Research Center requests competitive renewal of funding. Four research projects and two cores are proposed in this application. We will leverage the unique structure of the P50 and our large cohort of CI subjects from our patient registry to develop predictive models at the group and individual levels incorporating peripheral, cortical, cognitive, and language processing insights to predict outcomes in real-world challenging listening environments (i.e., natural listening environments). The four research projects are highly integrated and depend on data from each other to answer the experimental questions proposed.

项目负责人/主要研究者（最后一位、第一位、中间一位）：J. J. J.布鲁斯。项目概要-概述耳蜗植入体（CI）已成为治疗深度感音神经性听力损失的标准护理。这些设备在安静的情况下提供了对单词理解的显著改善，但是在嘈杂的情况下具有限制。背景在现实世界环境中难以理解噪声中的语音感知（SiN）是其中之一。任何类型的听力障碍患者寻求听力的最常见投诉康复活动.我们认为，理解SiN的能力是听觉周边的产物，皮层和认知过程提供的可塑性。在皮层和认知处理的水平上，先前的工作已经确定了一套认知机制，包括图形/背景分离和与信号质量相互作用以影响SiN结果的词汇处理。在此基础上，我们现在必须扩大调查，以更好地了解其他重要因素的影响，如高阶认知过程（例如，工作记忆和执行功能），具有很高的协助潜力改善听力损失患者的SiN能力。此外，了解这些在现实世界中的沟通和社交能力及其对心理社会健康的影响，可能会对认知稳定性产生长期影响。这项拨款采用多管齐下的方法，解析所有听觉系统层面的关键问题，因为它涉及到现实世界的听力理解。通过利用各种CI用户（例如，SSD，Bilateral，A+E），我们可以扩展我们对以下内容的理解：1）残余听力丧失的机制以及这些机制如何促进更好的保护结果; 2）听众如何适应和融合A+E信息，以提高现实世界中的听力个体的认知功能是否有助于A+E加工的整合。此外，我们认识到，通信困难超越SiN性能;我们将调查在快速、安静或有口音的讲话中，在混响环境中，提示（例如，戴口罩）。爱荷华州髋关节植入物临床研究中心要求资金的更新。本申请提出了四个研究项目和两个核心。我们将利用 P50的独特结构和我们的患者登记处的CI受试者的大型队列，以开发预测在群体和个体水平上的模型，包括外围、皮层、认知和语言处理预测现实世界中具有挑战性的收听环境中的结果的见解（即，自然收听环境）。这四个研究项目高度融合，依赖于彼此的数据来回答提出的实验问题。