CE19-001, The Penn Injury Science Center

CE19-001，宾夕法尼亚州损伤科学中心

• 批准号: 10640207
• 负责人: ZACHARY Franklin MEISEL
• 金额: $ 100.66万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10640207
• 关键词: CE19; 001; Penn; Injury; Science

PROJECT SUMMARY We propose the Penn Injury Science Center (PISC) as an ICRC at the University of Pennsylvania (Penn) focusing on the reduction of injuries and violence through the highest caliber science, education, and outreach that addresses the intersecting impacts of risk and protective exposures across space and time. Our research ranges in geographic and temporal scale from broad to highly granular, and we study vulnerable populations at scales ranging from a precise within-person or within-activity level to a broad macro or policy level depending on the nature of the injury and violence scenario that is at issue and the state of evidence in that area of injury science. Most injury or violence events have multiple component causes. Our space-time lens helps us appreciate the complexity of injury prevention science and use that understanding to hone in on the determinants and points of intervention that, if targeted, would allow us to achieve the greatest injury prevention impact. Our space-time approach acknowledges that we may never be aware of some of the exposures that contribute to cause an injury and that, even among identified exposures, some may not be measureable. But, by appreciating the complexity of injury events, we are better able to target the risk factors that are the most amenable to change and, likewise, the protective factors that are most feasible to promote. The goal of the PISC is to promote and perform the highest quality research, training, and translation of scientific discoveries into practice and policy, in order to reduce injuries, violence, and their impact nationwide, particularly among vulnerable and underserved populations. Populations may be vulnerable or underserved due to many factors, including the places they live, work and spend time, sports they play, the policies of the state where they live, structural racism, and many other factors. Hence the focus of the injury prevention science led by PISC investigators addresses topics and populations in many contexts and geographic locations. The proposed Center is organized around 4 Cores (the Administrative Core, the Outreach Core, the Training and Education Core, and the Research Core) with support and input from Internal and External Advisory Boards, and a Community Action Board. The Center has proposed 4 fully developed Research Projects in this application and will support an Exploratory Grant Program to fund pilot research in injury and violence prevention priority areas. The Research Projects include a translational implementation trial towards improving warm handoff pathways for opioid use disorder, reducing motor vehicle crashes in newly licensed drivers, applying innovative technology to reduce falls in older adults, and examining the intersection of adverse childhood experiences (ACEs) and neighborhood exposures on health and injury outcomes. The PISC leadership, faculty, trainees, and partners, thus, will collaborate to conduct important research, training, and translation activities that engage the Penn community and local and national stakeholders in implementing and advancing a fully funded and sustainable comprehensive ICRC.

项目总结 我们建议宾夕法尼亚大学伤害科学中心(PISC)作为宾夕法尼亚大学(Penn)的红十字委员会。 专注于通过最高水平的科学、教育和 开展外联活动，解决跨空间和跨空间的风险和保护性暴露的交叉影响 时间到了。我们的研究范围从广泛的地理和时间尺度到高度细粒度，我们研究 脆弱人群的规模从精确的个人内部或内部活动水平到广泛的宏观水平 或政策级别，取决于所涉伤害和暴力情景的性质以及 伤害科学领域的证据。大多数伤害或暴力事件有多个组成部分的原因。我们的 时空透镜帮助我们认识到伤害预防科学的复杂性，并使用 理解，以磨练决定因素和干预点，如果有针对性，将允许 我们要达到最大的防伤效果。我们的时空方法承认我们可能 永远不要意识到一些会导致伤害的暴露，即使是在确定的 暴露，有些可能是无法衡量的。但是，通过认识到受伤事件的复杂性，我们做得更好 能够针对最容易改变的风险因素，以及同样的保护性因素 是最可行的推广方式。PISC的目标是促进和执行最高质量的研究， 培训，并将科学发现转化为实践和政策，以减少伤害、暴力、 及其在全国范围内的影响，特别是在弱势和未得到充分服务的人群中。人口可能是 由于许多因素，包括他们生活、工作和花费时间的地方，体育运动，易受伤害或服务不足 他们发挥作用，他们居住的国家的政策，结构性种族主义，以及许多其他因素。因此人们关注的焦点 由PISC研究人员领导的伤害预防科学研究在许多背景下解决了主题和人群 和地理位置。拟议的中心围绕4个核心(行政核心、 外展核心、培训和教育核心以及研究核心)，得到内部的支持和投入 和外部咨询委员会，以及社区行动委员会。该中心提出了4个全面开发的方案 此应用程序中的研究项目，并将支持探索性拨款计划，以资助 预防伤害和暴力的优先领域。研究项目包括翻译实施试验 改善阿片类药物使用障碍的温暖移交路径，减少新的机动车撞车事故 有执照的司机，应用创新技术减少老年人跌倒，并检查十字路口 不良童年经历(ACE)和社区暴露对健康和伤害后果的影响。这个 因此，PISC领导层、教职员工、实习生和合作伙伴将合作进行重要研究， 培训和翻译活动，让宾夕法尼亚大学社区以及当地和国家参与 在执行和推进一个资金充足和可持续的全面红十字国际委员会方面，与各利益攸关方密切合作。

项目成果

Redesign of Opioid Use Disorder Screening and Treatment in the ED.

急诊科阿片类药物使用障碍筛查和治疗的重新设计。

• DOI: 10.1056/cat.21.0297
• 发表时间: 2022
• 期刊: NEJM catalyst innovations in care delivery
• 作者: Lowenstein,Margaret;McFadden,Rachel;Abdel-Rahman,Dina;Perrone,Jeanmarie;Meisel,ZacharyF;O'Donnell,Nicole;Wood,Christian;Solomon,Gabrielle;Beidas,Rinad;Delgado,MKit
• 通讯作者: Delgado,MKit

Applying the Haddon matrix conceptual model to guide motor vehicle crash injury research and prevention in Botswana.

• DOI: 10.1016/j.afjem.2020.04.006
• 发表时间: 2020
• 期刊: African journal of emergency medicine : Revue africaine de la medecine d'urgence
• 作者: Bocage C;Mashalla Y;Motshome P;Fane O;Masilo-Nkhoma L;Mathiba O;Mautle E;Kuiperij B;Mmusi T;Holmes JH;Tam V;Barg FK;Wiebe DJ
• 通讯作者: Wiebe DJ

Variability in opioid use disorder clinical presentations and treatment in the emergency department: A mixed-methods study.

阿片类药物使用障碍临床表现和急诊科治疗的变异性：一项混合方法研究。

• DOI: 10.1016/j.ajem.2023.01.009
• 发表时间: 2023
• 期刊: The American journal of emergency medicine
• 作者: Faude,Sophia;Delgado,MKit;Perrone,Jeanmarie;McFadden,Rachel;Xiong,RuiyingAria;O'Donnell,Nicole;Wood,Christian;Solomon,Gabrielle;Lowenstein,Margaret
• 通讯作者: Lowenstein,Margaret

Sustained Implementation of a Multicomponent Strategy to Increase Emergency Department-Initiated Interventions for Opioid Use Disorder.

• DOI: 10.1016/j.annemergmed.2021.10.012
• 发表时间: 2022-03
• 期刊: Annals of emergency medicine
• 影响因子: 6.2
• 作者: Lowenstein M;Perrone J;Xiong RA;Snider CK;O'Donnell N;Hermann D;Rosin R;Dees J;McFadden R;Khatri U;Meisel ZF;Mitra N;Delgado MK
• 通讯作者: Delgado MK