Project 2: Technology Support for Cognition and Social Engagement for Aging Adults with Mild Cognitive Impairment (MCI)

项目 2：为患有轻度认知障碍 (MCI) 的老年人提供认知和社会参与的技术支持

• 批准号: 10641788
• 负责人: Walter Richard Boot
• 金额: $ 46.82万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-15 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641788
• 关键词: Acceleration; Activities of Daily Living; Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Attitude; Behavioral Model; Cognition; Cognitive; Communities; Computer software; Data; Dementia; Deterioration; Education; Elderly; Electronic Mail; Emotional; Enhancement Technology; Evaluation; Feeling; Focus Groups; Goals; Health; Impaired cognition; Individual; Intelligence; Intervention; Interview; Knowledge; Language; Link; Measures; Memory; Methods; Modeling; Older Population; Outcome; Perception; Performance; Personal Satisfaction; Persons; Pharmacological Treatment; Phase; Population; Production; Protocols documentation; Quality of life; Randomized; Research; Research Personnel; Resources; Risk; Sampling; Secondary Prevention; Site; Social isolation; Social support; Speech; Surveys; System; Systems Development; Tablets; Technology; Testing; Time; Training; Training Programs; United States National Institutes of Health; Videoconferencing; Waiting Lists; aged; aging and technology; care providers; cognitive ability; cognitive function; cognitive performance; cognitive rehabilitation; cognitive testing; cognitive training; design; diagnostic algorithm; effective intervention; experience; functional improvement; functional independence; hands-on learning; implementation barriers; improved; information gathering; innovation; innovative technologies; insight; instrumental activity of daily living; iterative design; mild cognitive impairment; multi-component intervention; normal aging; phase 1 study; pilot test; post intervention; preference; prevent; preventive intervention; social; social engagement; technology validation; therapy development; tool; usability; user centered design

Project Summary Currently 15-20% of adults aged 65+ have Mild Cognitive Impairment (MCI) and a large percentage of these individuals will develop Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD). Individuals with MCI demonstrate difficulties performing a wide range of everyday activities and experience social isolation. Investigators have begun to look at technology-based interventions to improve the functioning of aging adults with cognitive impairment. Most of these efforts have focused on the provision of cognitive training or rehabilitation and have not included other aspects of functioning such as everyday activities or social engagement. The goal of this Stage 1 (NIH Stage Model) Intervention Development cross-site project is to develop, using a user-centered design approach, and evaluate an innovative intelligent adaptive software package aimed at providing cognitive and social support and engagement to older adults with MCI. The system will be designed to adapt to the needs and abilities of the user. Phase 1, akin to Stage 1a, will involve interviews with aging adults with MCI and care providers to gather information on challenges encountered in everyday activities and types of technology support features of potential benefit. We will also evaluate different features of the system (e.g., adaptive interface features), with an iterative design approach with diverse samples of individuals with MCI. We anticipate conducting two rounds of usability testing per site. Phase 2, akin to Stage 1b, will involve pilot testing to evaluate the feasibility and usability of the system with a sample of 68 individuals with MCI at each of the three CREATE sites (N=204) and to gather preliminary data on the efficacy of the proposed system. We will use a waitlist control, pre-post design (waitlist group will receive the technology after six months and assessed again at 12 months). A battery of measures that includes demographic information, attitudes towards technology, tablet proficiency, technology experience, performance of activities targeted in the training components, functional independence and well-being, social support/isolation, and quality of life will be administered at baseline, 6 months post randomization, and after another 6 months for the waitlist group. We will also assess potential cognitive ability changes. We will conduct interviews 6-month post intervention to assess likes, dislikes, and challenges with the system. Our goal is to develop a unique and highly innovative technology tool that can provide adaptive support to aging individuals with MCI, even as cognition might deteriorate further. Speech data collected as part of an embedded reminiscence feature will advance fundamental knowledge of how speech and language production data might serve as an early indicator of cognitive decline. The project will yield important information on the feasibility of using technology-based approaches to support everyday activities and cognition for persons with MCI and insight on barriers to the implementation of technology-based interventions. We will also gain understanding of the challenges aging adults with MCI encounter in everyday activities.

项目摘要 目前15-20％的65岁以上的成年人患有轻度认知障碍（MCI），其中很大一部分 个体将发展阿尔茨海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD）。 MCI的个人表现出难以执行各种日常活动和经验 社交隔离。调查人员已经开始研究基于技术的干预措施以改善功能 认知障碍的成年人的老化。这些努力大部分都集中在认知的提供上 培训或康复，没有包括日常活动等功能的其他方面 社交参与。此阶段1（NIH阶段模型）干预开发跨站点项目的目标是 使用以用户为中心的设计方法开发并评估创新的智能自适应软件 旨在通过MCI为老年人提供认知和社会支持和参与的套餐。系统 旨在适应用户的需求和能力。类似于第1A阶段的第1阶段将涉及 与MCI和护理提供者的老年人访谈，以收集有关遇到的挑战的信息 日常活动和类型的技术支持潜在利益的特征。我们还将评估不同的 系统的功能（例如，自适应接口功能），具有多种多样的迭代设计方法 MCI的个体样本。我们预计每个站点会进行两轮可用性测试。阶段2， 类似于第1B期，将涉及试点测试，以评估系统的可行性和可用性 在三个创建站点中的每个站点中的每个人（n = 204）中，有68位MCI的人并收集有关 拟议系统的功效。我们将使用候补列表控件，PES POST设计（候补名单组将接收 六个月后的技术，在12个月时再次进行评估）。一系列措施，包括 人口统计信息，对技术的态度，平板电脑熟练度，技术经验，性能 培训组成部分，功能独立性和福祉的活动的活动 支持/隔离和生活质量将在基线，随机后6个月以及之后进行 候补名单小组还有6个月。我们还将评估潜在的认知能力变化。我们将进行 访谈6个月后干预以评估系统的喜好，不喜欢和挑战。我们的目标是 开发一种独特且高度创新的技术工具，可以为老龄化个人提供自适应支持 使用MCI，即使认知可能会进一步恶化。作为嵌入式的一部分收集的语音数据 回忆功能将促进言语和语言生产数据的基本知识 作为认知能力下降的早期指标。该项目将产生有关可行性的重要信息 使用基于技术的方法来支持MCI和MCI和人的认知 洞悉实施基于技术干预措施的障碍。我们还将了解 在日常活动中，与MCI相遇的成年人衰老的挑战。