The Adherence Promotion with Person-centered Technology (APPT) Project: Promoting Adherence to Enhance the Early Detection and Treatment of Cognitive Decline

以人为本的技术 (APPT) 项目的依从性促进：促进依从性以加强认知衰退的早期发现和治疗

• 批准号: 10611019
• 负责人: Walter Richard Boot
• 金额: $ 9.89万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10611019
• 关键词: Address; Adherence; Adopted; Age; Age-associated memory impairment; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Artificial Intelligence; Attitude; Caring; Clinical Trials; Cognition; Cognitive; Cognitive aging; Computer software; Coupled; Data; Dementia; Development; Early Diagnosis; Early treatment; Elderly; Ensure; Failure; Family; Goals; Health; Health Status; Health behavior; Home; Human; Impaired cognition; Individual; Individual Differences; Intervention; Intervention Studies; Interview; Life Style; Measurement; Measures; Mediating; Methods; Needs Assessment; Participant; Personal Satisfaction; Personality; Population; Positioning Attribute; Prevention; Process; Protocols documentation; Randomized Controlled Trials; Reminder Systems; Research; Resources; Risk; Sampling; Schedule; Shapes; Structure; Support System; Technology; Testing; Time; Training; Treatment Efficacy; Weight; aging population; algorithm development; artificial intelligence algorithm; base; behavioral adherence; cognitive ability; cognitive change; cognitive performance; cognitive testing; cognitive training; design; experience; functional independence; improved; insight; mild cognitive impairment; mobile computing; next generation; person centered; prediction algorithm; preference; prevent; public health relevance; success; therapy design; tool; usability

Many older adults experience declines in cognitive ability that can be substantial, including mild cognitive impairment and Alzheimer’s disease and AD-related dementia. Population aging, coupled with age-related cognitive impairment, including Alzheimer’s disease and other dementias, represents an unprecedented challenge. Early detection of cognitive impairment is a crucial goal. This would allow individuals at risk for mild cognitive impairment and/or AD/ADRD to adopt lifestyle changes to minimize decrements and the risk for acquired cognitive impairment. However, the massive potential of cognitive training and longitudinal assessment to detect and prevent age-related cognitive impairment and dementia are unlikely to be realized unless individuals are willing and able to engage with these protocols for an extended period of time. Adherence to cognitive assessment and training is often poor. Addressing the gap between potential and realized benefits of early detection and prevention of cognitive impairment is an urgent goal as the population ages. The aims of the Adherence Promotion with Person-centered Technology (APPT) project are to promote early detection and treatment of age-related cognitive impairment and dementia by 1) enhancing adherence to cognitive intervention and assessment protocols, 2) improving understanding of barriers to long-term adherence, and 3) assisting in the development of algorithms for predicting and preventing adherence failures. Projects aim to investigate these issues within samples of older adults with and without cognitive impairment. Two randomized controlled trials will test an adaptive, tailored, and integrated technology support system predicted to boost adherence to cognitive protocols, over and above a simpler scheduling and reminder system over 6 months. Studies will provide valuable and generalizable insight into not only the benefits of adherence support, but also the individual difference factors that shape protocol adherence (e.g., attitudes, cognitive ability, dementia status, health status, personality, technology proficiency). Data will inform the process of identifying individuals who would benefit from additional support, and predicting and preventing extended adherence failures before they happen. By increasing adherence, these studies will help improve early detection and treatment of cognitive impairment, which will ultimately extend older adults' functional independence, improving their lives and the lives of their families, and reducing care and support resources needed to address lost independence like that associated with Alzheimer’s disease and AD-related dementia. Further, intervention studies for dementia and Alzheimer’s disease can be made more efficient through tools for identifying individuals likely to experience decline before substantial cognitive impairment has occurred. Results have implications that extend far beyond cognitive impairment; the methods and mechanisms uncovered have broad implications for technology-mediated assessment and protocols to enhance health and well-being in general. The project consists of two large randomized controlled trials and smaller needs assessment and usability studies that will guide their development and deployment.

许多老年人的认知能力下降，可能是实质性的，包括轻度认知障碍和阿尔茨海默病和AD相关的痴呆症。人口老龄化，加上与年龄有关的认知障碍，包括阿尔茨海默病和其他痴呆症，是一个前所未有的挑战。早期发现认知障碍是一个至关重要的目标。这将允许有轻度认知障碍和/或AD/ADRD风险的个体改变生活方式，以尽量减少递减和获得性认知障碍的风险。然而，认知训练和纵向评估检测和预防与年龄相关的认知障碍和痴呆症的巨大潜力不太可能实现，除非个人愿意并能够长期参与这些协议。对认知评估和培训的坚持往往很差。随着人口老龄化，解决认知障碍的早期检测和预防的潜在益处与已实现益处之间的差距是一个紧迫的目标。以人为本的技术（APPT）项目的目的是促进早期发现和治疗年龄相关的认知障碍和痴呆症，方法是：1）加强对认知干预和评估方案的依从性，2）提高对长期依从性障碍的理解，3）协助开发预测和预防依从性失败的算法。项目旨在调查有和没有认知障碍的老年人样本中的这些问题。两项随机对照试验将测试一种自适应、定制和集成的技术支持系统，该系统预计将在6个月内提高对认知协议的遵守，而不是更简单的日程安排和提醒系统。研究将提供有价值的和可推广的见解，不仅是依从性支持的好处，而且是塑造方案依从性的个体差异因素（例如，态度、认知能力、痴呆状态、健康状况、个性、技术熟练程度）。数据将为识别将从额外支持中受益的个人的过程提供信息，并预测和预防长期坚持失败。通过增加依从性，这些研究将有助于改善认知障碍的早期发现和治疗，最终延长老年人的功能独立性，改善他们的生活和家人的生活，并减少治疗所需的护理和支持资源。此外，痴呆症和阿尔茨海默氏病的干预研究可以通过在发生严重认知障碍之前识别可能经历衰退的个体的工具变得更有效。结果的影响远远超出了认知障碍;所揭示的方法和机制对技术介导的评估和协议具有广泛的影响，以提高健康和福祉。该项目包括两个大型随机对照试验和较小的需求评估和可用性研究，这些研究将指导其开发和部署。