Center on Emerging and Zoonotic Infectious Diseases

新发和人畜共患传染病中心

• 批准号: 10642671
• 负责人: Juergen A Richt
• 金额: $ 226.01万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642671
• 关键词: Achievement; Address; Advisory Committees; Aging; Animal Diseases; Animal Model; Animals; Applications Grants; Area; Arts; Award; Basic Science; Cell Culture Techniques; Centers of Research Excellence; Climate; Collaborations; Communicable Diseases; Core Facility; Development Plans; Disease; Emerging Communicable Diseases; Ensure; Environment; Extramural Activities; Faculty; Faculty Recruitment; Funding; Future; Goals; Grant; Growth; Health; In Vitro; Incidence; Infectious Diseases Research; Institution; Interdisciplinary Study; International; Island; Kansas; Laboratories; Mentors; Microbe; Mission; Molecular and Cellular Biology; Nebraska; Participant; Pathology; Pathway interactions; Persons; Pilot Projects; Plum; Postdoctoral Fellow; Process; Productivity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Retirement; Science; Secure; Security; Strategic Planning; System; Training; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; Viral; Virulence Factors; Work; Zoonoses; biosafety level 4 facility; college; doctoral student; faculty mentor; graduate student; improved; inter-institutional; interest; laboratory facility; medical schools; member; novel therapeutics; novel vaccines; pathogen; programs; rapid growth; recruit; research facility; success; symposium; synergism; training opportunity; translational approach

Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Sciences and Veterinary Medicine. The projects examine virulence factors and host-pathogen interactions of various pathogens, utilizing both basic and translational approaches in in vitro systems and in animal models. The overarching goal of the EZID center is to advance our understanding of emerging and zoonotic infectious diseases in the State of Kansas. Our goals are also clearly aligned with NIH's strategic plan “Turning Discovery into Health”. Two research core facilities will support the research projects and programs, an Animal Model/Pathology Core and a Molecular and Cellular Biology Core, offering unique research infrastructure resources within KSU and the State of Kansas. The success and growth of EZID will be enabled through various programs: (1) a faculty mentoring program that will provide outstanding mentoring by nationally/internationally recognized mentors. The mentoring team will implement individualized development plans, and support all aspects of research programs and grant application processes to secure R01-level funding by the project leaders; (2) new faculty recruitment at KSU to ensure the growth and sustainability of EZID, as well as productive use of core facilities; (3) a pilot and seed grant program that will promote center growth by funding projects at universities within the State of Kansas; and (4) a regional scientific network (RSN) that will provide inter-disciplinary and inter-institutional collaborations, increased usage of core facilities, and access to additional core facilities and training opportunities. Initial partners of the RSN include several COBREs within the State of Kansas and Nebraska, as well as the K-INBRE center at the University of Kansas Medical School. The RSN will grow and expand both to other universities in the region and to national COBRE centers working in the same mission space, thereby providing opportunities for the rapid growth of research programs. These EZID programs will be the basis by which research productivity is enabled and supported, helping to advance the overall success and reputation of the COBRE core projects, pilot projects, post-doctoral and graduate student trainees, and associated EZID faculty. The EZID center will host annual research symposia that will include participants from EZID projects and RSN members to showcase and share research with investigators from inside and outside of the network, promoting the national and international reputation of EZID.

总体项目总结： 这项Cobre申请将形成一个独特的新发和人畜共患传染病研究中心 (EZID)。四个主要研究项目连接了传染病方案中的优秀领域，网址为 堪萨斯州立大学(KSU)文理学院和兽医学院。这个 项目检查各种病原体的毒力因子和宿主-病原体的相互作用，利用基础和 体外系统和动物模型中的翻译方法。EZID中心的首要目标是 促进我们对堪萨斯州新出现的和人畜共患传染病的了解。我们的目标是 这也与美国国立卫生研究院的“把发现变成健康”的战略计划相一致。两个研究核心设施将 支持研究项目和计划，一个动物模型/病理学核心和一个分子和细胞 生物核心，在KSU和堪萨斯州内提供独特的研究基础设施资源。这个 EZID的成功和发展将通过各种计划实现：(1)教师指导计划， 将由国家/国际公认的导师提供出色的指导。指导团队将 实施个性化发展计划，全方位支持科研项目和资助申请 确保项目负责人获得R01级资金的程序；(2)在KSU招聘新教师，以确保 EZID的增长和可持续性，以及核心设施的生产性利用；(3)试点和种子赠款 将通过资助堪萨斯州内大学的项目来促进中心发展的计划；以及(4) 将提供跨学科和跨机构合作的区域科学网络(RSN)， 更多地使用核心设施，并获得更多的核心设施和培训机会。首字母 RSN的合作伙伴包括堪萨斯州和内布拉斯加州的几个科布雷人以及K-INBRE 堪萨斯大学医学院的研究中心。RSN将发展并扩展到#年的其他大学 该区域和在同一任务空间工作的国家科布雷中心，从而提供了机会 因为研究项目的快速增长。这些EZID计划将成为研究生产力的基础 得到支持和支持，有助于推动科布雷核心项目的整体成功和声誉， 试点项目、博士后和研究生实习生以及EZID相关教职员工。EZID中心将 主办年度研究研讨会，将包括来自EZID项目和RSN成员的参与者进行展示 并与来自网络内外的调查人员分享研究成果，促进国家和 EZID的国际声誉。

项目成果

Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs.

• DOI: 10.1186/s44149-022-00051-x
• 发表时间: 2022
• 期刊: Animal diseases

Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation.

• DOI: 10.3390/v13081662
• 发表时间: 2021-08-21
• 期刊: Viruses
• 作者: Dacus D;Wallace NA
• 通讯作者: Wallace NA

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.

• DOI: 10.1080/22221751.2021.1903343
• 发表时间: 2021-12
• 期刊: Emerging microbes & infections
• 影响因子: 13.2
• 作者: Morozov I;Monath TP;Meekins DA;Trujillo JD;Sunwoo SY;Urbaniak K;Kim IJ;Narayanan SK;Indran SV;Ma W;Wilson WC;O'Connor C;Dubey S;Troth SP;Coller BA;Nichols R;Martin BK;Feldmann H;Richt JA
• 通讯作者: Richt JA

Epizootic Haemorrhagic Disease Virus Serotype 8 in Tunisia, 2021.

• DOI: 10.3390/v15010016
• 发表时间: 2022-12-21
• 期刊: Viruses

Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 Pandemic.

• DOI: 10.3389/fvets.2021.707368
• 发表时间: 2021
• 期刊: Frontiers in veterinary science
• 影响因子: 3.2
• 作者: Yilmaz A;Kayar A;Turan N;Iskefli O;Bayrakal A;Roman-Sosa G;Or E;Tali HE;Kocazeybek B;Karaali R;Bold D;Sadeyen JR;Lukosaityte D;Chang P;Iqbal M;Richt JA;Yilmaz H
• 通讯作者: Yilmaz H