Center on Emerging and Zoonotic Infectious Diseases

新发和人畜共患传染病中心

• 批准号: 10642671
• 负责人: Juergen A Richt
• 金额: $ 226.01万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642671
• 关键词: Achievement; Address; Advisory Committees; Aging; Animal Diseases; Animal Model; Animals; Applications Grants; Area; Arts; Award; Basic Science; Cell Culture Techniques; Centers of Research Excellence; Climate; Collaborations; Communicable Diseases; Core Facility; Development Plans; Disease; Emerging Communicable Diseases; Ensure; Environment; Extramural Activities; Faculty; Faculty Recruitment; Funding; Future; Goals; Grant; Growth; Health; In Vitro; Incidence; Infectious Diseases Research; Institution; Interdisciplinary Study; International; Island; Kansas; Laboratories; Mentors; Microbe; Mission; Molecular and Cellular Biology; Nebraska; Participant; Pathology; Pathway interactions; Persons; Pilot Projects; Plum; Postdoctoral Fellow; Process; Productivity; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Retirement; Science; Secure; Security; Strategic Planning; System; Training; Translational Research; United States National Institutes of Health; Universities; Veterinary Medicine; Viral; Virulence Factors; Work; Zoonoses; biosafety level 4 facility; college; doctoral student; faculty mentor; graduate student; improved; inter-institutional; interest; laboratory facility; medical schools; member; novel therapeutics; novel vaccines; pathogen; programs; rapid growth; recruit; research facility; success; symposium; synergism; training opportunity; translational approach

Overall Project Summary: This COBRE application will form a unique research center on Emerging and Zoonotic Infectious Diseases (EZID). Four primary research projects bridge areas of excellence in the Infectious Diseases programs at Kansas State University (KSU) within the Colleges of Arts and Sciences and Veterinary Medicine. The projects examine virulence factors and host-pathogen interactions of various pathogens, utilizing both basic and translational approaches in in vitro systems and in animal models. The overarching goal of the EZID center is to advance our understanding of emerging and zoonotic infectious diseases in the State of Kansas. Our goals are also clearly aligned with NIH's strategic plan “Turning Discovery into Health”. Two research core facilities will support the research projects and programs, an Animal Model/Pathology Core and a Molecular and Cellular Biology Core, offering unique research infrastructure resources within KSU and the State of Kansas. The success and growth of EZID will be enabled through various programs: (1) a faculty mentoring program that will provide outstanding mentoring by nationally/internationally recognized mentors. The mentoring team will implement individualized development plans, and support all aspects of research programs and grant application processes to secure R01-level funding by the project leaders; (2) new faculty recruitment at KSU to ensure the growth and sustainability of EZID, as well as productive use of core facilities; (3) a pilot and seed grant program that will promote center growth by funding projects at universities within the State of Kansas; and (4) a regional scientific network (RSN) that will provide inter-disciplinary and inter-institutional collaborations, increased usage of core facilities, and access to additional core facilities and training opportunities. Initial partners of the RSN include several COBREs within the State of Kansas and Nebraska, as well as the K-INBRE center at the University of Kansas Medical School. The RSN will grow and expand both to other universities in the region and to national COBRE centers working in the same mission space, thereby providing opportunities for the rapid growth of research programs. These EZID programs will be the basis by which research productivity is enabled and supported, helping to advance the overall success and reputation of the COBRE core projects, pilot projects, post-doctoral and graduate student trainees, and associated EZID faculty. The EZID center will host annual research symposia that will include participants from EZID projects and RSN members to showcase and share research with investigators from inside and outside of the network, promoting the national and international reputation of EZID.

总体项目摘要： 该毛线应用将构成有关新兴和人畜共患感染疾病的独特研究中心 （Ezid）。四个主要研究项目桥梁在传染病计划中的卓越领域 堪萨斯州立大学（KSU）在艺术与科学和兽医学院内。这 项目使用碱性和 体外系统和动物模型中的翻译方法。电子齐德中心的总体目标是 促进我们对堪萨斯州新兴和人畜共患感染疾病的理解。我们的目标是 也显然与NIH的战略计划“将发现变成健康”。两个研究核心设施将 支持研究项目和程序，动物模型/病理核心以及分子和细胞 生物学核心，在KSU和堪萨斯州内提供独特的研究基础设施资源。这 通过各种计划将启用电子齐德的成功和成长：（1）教师心理计划，该计划 将通过国家/国际认可的精神提供出色的心理。心理团队将 实施个性化的发展计划，并支持研究计划的各个方面并授予应用 为了确保项目负责人获得R01级资金的流程； （2）KSU的新教师招聘 电子齐德的增长和可持续性，以及核心设施的富有成效使用； （3）飞行员和种子赠款 计划通过在堪萨斯州的大学资助项目来促进中心增长的计划； （4） 一个区域科学网络（RSN），将提供跨学科和机构间合作， 增加了核心设施的使用，并获得了其他核心设施和培训机会。最初的 RSN的合作伙伴包括堪萨斯州和内布拉斯加州州内的几个Cobres，以及K-Inbre 堪萨斯大学医学院的中心。 RSN将在其他大学中发展并扩展到其他大学 该地区以及在同一任务领域工作的国家田园中心，从而提供机会 为了快速发展研究计划。这些真皮计划将是研究生产力的基础 启用和支持，有助于促进Cobre Core Project的整体成功和声誉， 试点项目，博士后和研究生学员以及相关的Ezid教师。电子齐德中心将 主持年度研究研讨会，其中包括Ezid项目和RSN成员的参与者展示 并与来自网络内部和外部的调查人员分享研究，促进国家和 Ezid的国际评论。

项目成果

Epizootic Haemorrhagic Disease Virus Serotype 8 in Tunisia, 2021.

• DOI: 10.3390/v15010016
• 发表时间: 2022-12-21
• 期刊: Viruses

Evaluating α-galactosylceramide as an adjuvant for live attenuated influenza vaccines in pigs.

• DOI: 10.1186/s44149-022-00051-x
• 发表时间: 2022
• 期刊: Animal diseases

High dose of vesicular stomatitis virus-vectored Ebola virus vaccine causes vesicular disease in swine without horizontal transmission.

• DOI: 10.1080/22221751.2021.1903343
• 发表时间: 2021-12
• 期刊: Emerging microbes & infections
• 影响因子: 13.2
• 作者: Morozov I;Monath TP;Meekins DA;Trujillo JD;Sunwoo SY;Urbaniak K;Kim IJ;Narayanan SK;Indran SV;Ma W;Wilson WC;O'Connor C;Dubey S;Troth SP;Coller BA;Nichols R;Martin BK;Feldmann H;Richt JA
• 通讯作者: Richt JA

Beta-Genus Human Papillomavirus 8 E6 Destabilizes the Host Genome by Promoting p300 Degradation.

• DOI: 10.3390/v13081662
• 发表时间: 2021-08-21
• 期刊: Viruses
• 作者: Dacus D;Wallace NA
• 通讯作者: Wallace NA

Beta HPV Deregulates Double-Strand Break Repair.

• DOI: 10.3390/v14050948
• 发表时间: 2022-04-30
• 期刊: Viruses