Epidemiology, Biostatistics and Study Design (EBSD) Core

流行病学、生物统计和研究设计(EBSD)核心将提高 肌肉骨骼研究通过提供独特的流行病学资源来鼓励 基础、翻译和临床研究人员，并为研究人员提供关键的咨询服务 和教育工具，以确保其工作的严谨性和可重复性。因此，EBSD核心覆盖了 从板凳到床边的连续体，旨在为所有核心肌肉骨骼生物学中心和 医学(CCMBM)成员。 拟议的EBSD核心将建立在目前CCMBM流行病学和 生物统计核心，维持成功的项目并增加新的、创新的举措。该计划的一个主要目标 EBSD的核心是提供获取和方便使用大型骨质疏松症和骨关节炎(OA)的纵向 由加州大学旧金山分校协调的观察性研究和临床试验的数据库，包括RICH相关 生物和成像资源(目标1)。这些研究和试验得到了NIAMS和其他NIH的资助 研究所和非NIH实体。通过促进使用这些独特的临床研究资源，EBSD核心将 使CCMBM成员能够测试关于发病机制、自然病史、风险的假设和技术 因素，以及骨和关节疾病的诊断。EBSD的另一个核心目标是提供个性化的 向CCMBM社区提供咨询服务(目标2)。核心将增加对研究的获取和使用 设计、生物统计、数据管理和相关咨询，使用核心资源并利用 加州大学旧金山分校临床和翻译科学研究所(CTSI)咨询服务(目标2a)。当它这样做的时候，核心 还将加强加州大学旧金山分校以患者为导向的肌肉骨骼健康临床研究，方法是创建 创新的“研究实施辅导”服务，面向初级调查员和其他新进入该领域的人员 (目标2b)。为了进一步扩大核心的影响范围，核心董事和联席董事将加强 临床科室和研究小组内的肌肉骨骼研究机会 在这些群体中协作和嵌入流行病学家(目标2c)。最后，EBSD核心将 教育CCMBM社区(目标3)，培训研究人员良好的研究设计和执行实践 在分析方法上，最大限度地提高他们工作的严谨性和有效性。这将涉及小说的创作， 专门为肌肉骨骼研究人员量身定做的定制教育模块，包括基础和 翻译调查员(目标3a)。核心课程还将通过以下方式增加获得和使用正式课程作业的机会 CCMBM成员利用加州大学旧金山分校的临床研究和骨质疏松症继续医学培训 教育项目。为了实现这些目标，EBSD核心将为CCMBM成员提供服务 从板凳到床边的连续体，提高生产力并刺激肌肉骨骼的协作 研究社区。

The Epidemiology, Biostatistics and Study Design (EBSD) Core will enhance productivity in musculoskeletal research by providing unique epidemiologic resources that encourage collaborations between basic, translational, and clinical researchers, and by supporting researchers with crucial consultative services and educational tools to ensure the rigor and reproducibility of their work. The EBSD Core thus reaches across the bench-to-bedside continuum and is designed to serve all Core Center for Musculoskeletal Biology and Medicine (CCMBM) members. The proposed EBSD Core will build on the achievements of the current CCMBM Epidemiology and Biostatistics Core, maintaining successful programs and adding new, innovative initiatives. One key aim of the EBSD Core is to provide access to and facilitate use of large osteoporosis and osteoarthritis (OA) longitudinal databases from observational studies and clinical trials coordinated by UCSF, including rich associated biological and imaging resources (Aim 1). These studies and trials have been funded by NIAMS, other NIH institutes, and non-NIH entities. By facilitating use of these unique clinical study resources, the EBSD Core will enable CCMBM members to test hypotheses and techniques regarding the pathogenesis, natural history, risk factors, and diagnosis of bone and joint diseases. Another EBSD Core objective is to provide individualized consultative services to the CCMBM community (Aim 2). The Core will increase access to and use of study design, biostatistical, data management, and related consultations, using Core resources and leveraging UCSF Clinical and Translational Science Institute (CTSI) consulting services (Aim 2a). As it does this, the Core will also strengthen patient-oriented clinical research in musculoskeletal health at UCSF by creating an innovative “study implementation coaching” service, targeting junior investigators and others new to the field (Aim 2b). To expand the Core’s reach even further, the Core Director and Co-Directors will enhance musculoskeletal research opportunities within clinical departments and research groups by building collaborations and embedding epidemiologists within those groups (Aim 2c). Finally, the EBSD Core will educate the CCMBM community (Aim 3), training investigators in good study design and execution practices and in analytic methods, to maximize the rigor and validity of their work. This will involve the creation of novel, customized educational modules specifically tailored to musculoskeletal investigators, including basic and translational investigators (Aim 3a). The Core will also increase access to and use of formal coursework by CCMBM members by leveraging the UCSF Training in Clinical Research and Osteoporosis Continuing Medical Education programs. In accomplishing these aims, the EBSD Core will serve CCMBM members across the bench-to-bedside continuum, enhancing productivity and stimulating collaborations in the musculoskeletal research community.