Epidemiology, Biostatistics and Study Design (EBSD) Core

流行病学、生物统计学和研究设计 (EBSD) 核心

• 批准号: 10215389
• 负责人: Dennis M Black
• 金额: $ 14.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10215389
• 关键词: Achievement; Address; Archives; Biological; Biology; Biometry; Biostatistical Methods; Biostatistics Core; Bone Density; Bone Diseases; Characteristics; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials; Cohort Studies; Collaborations; Communities; Community Medicine; Consult; Consultations; Custom; DNA; Data Analyses; Databases; Degenerative polyarthritis; Diagnosis; Educational Curriculum; Enrollment; Ensure; Epidemiologist; Epidemiology; Fracture; Funding; Guidelines; Health; Hip Osteoarthritis; Image; Individual; Institutes; Knee Osteoarthritis; Knowledge; Learning Module; Medicine; Musculoskeletal; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Natural History; Observational Study; Osteoporosis; Paper; Pathogenesis; Persons; Productivity; Protocols documentation; Reproducibility; Research; Research Design; Research Personnel; Resources; Risk Factors; Running; Scientist; Serum; Services; Source; Techniques; Testing; Training; Translational Research; United States National Institutes of Health; Whole Blood; Woman; Work; analytical method; arthropathies; bench to bedside; clinical database; clinical development; cohort; continuing medical education; data management; data resource; design; experience; follow-up; innovation; investigator training; longitudinal database; member; men; novel; osteoporosis with pathological fracture; patient oriented; programs; racial diversity; radiological imaging; randomized trial; success; tool; translational scientist

The Epidemiology, Biostatistics and Study Design (EBSD) Core will enhance productivity in musculoskeletal research by providing unique epidemiologic resources that encourage collaborations between basic, translational, and clinical researchers, and by supporting researchers with crucial consultative services and educational tools to ensure the rigor and reproducibility of their work. The EBSD Core thus reaches across the bench-to-bedside continuum and is designed to serve all Core Center for Musculoskeletal Biology and Medicine (CCMBM) members. The proposed EBSD Core will build on the achievements of the current CCMBM Epidemiology and Biostatistics Core, maintaining successful programs and adding new, innovative initiatives. One key aim of the EBSD Core is to provide access to and facilitate use of large osteoporosis and osteoarthritis (OA) longitudinal databases from observational studies and clinical trials coordinated by UCSF, including rich associated biological and imaging resources (Aim 1). These studies and trials have been funded by NIAMS, other NIH institutes, and non-NIH entities. By facilitating use of these unique clinical study resources, the EBSD Core will enable CCMBM members to test hypotheses and techniques regarding the pathogenesis, natural history, risk factors, and diagnosis of bone and joint diseases. Another EBSD Core objective is to provide individualized consultative services to the CCMBM community (Aim 2). The Core will increase access to and use of study design, biostatistical, data management, and related consultations, using Core resources and leveraging UCSF Clinical and Translational Science Institute (CTSI) consulting services (Aim 2a). As it does this, the Core will also strengthen patient-oriented clinical research in musculoskeletal health at UCSF by creating an innovative “study implementation coaching” service, targeting junior investigators and others new to the field (Aim 2b). To expand the Core’s reach even further, the Core Director and Co-Directors will enhance musculoskeletal research opportunities within clinical departments and research groups by building collaborations and embedding epidemiologists within those groups (Aim 2c). Finally, the EBSD Core will educate the CCMBM community (Aim 3), training investigators in good study design and execution practices and in analytic methods, to maximize the rigor and validity of their work. This will involve the creation of novel, customized educational modules specifically tailored to musculoskeletal investigators, including basic and translational investigators (Aim 3a). The Core will also increase access to and use of formal coursework by CCMBM members by leveraging the UCSF Training in Clinical Research and Osteoporosis Continuing Medical Education programs. In accomplishing these aims, the EBSD Core will serve CCMBM members across the bench-to-bedside continuum, enhancing productivity and stimulating collaborations in the musculoskeletal research community.

流行病学，生物统计学和研究设计（EBSD）核心将提高生产力， 肌肉骨骼研究，提供独特的流行病学资源，鼓励 基础、转化和临床研究人员，并通过为研究人员提供重要的咨询服务 和教育工具，以确保其工作的严谨性和可重复性。因此，EBSD核心跨越了 从工作台到床边的连续统一体，旨在为所有肌肉骨骼生物学核心中心提供服务， 医学（CCMBM）成员。 拟议的EBSD核心将建立在当前CCMBM流行病学的成就基础上， 生物统计学核心，保持成功的计划和增加新的，创新的举措。一个关键的目标， EBSD核心是提供访问和促进使用大型骨质疏松症和骨关节炎（OA）纵向 来自UCSF协调的观察性研究和临床试验的数据库，包括丰富的 生物和成像资源（目标1）。这些研究和试验由NIAMS，其他NIH 研究所和非NIH实体。通过促进这些独特的临床研究资源的使用，EBSD核心将 使CCMBM成员能够测试有关发病机制，自然史，风险 影响因素及骨关节疾病的诊断。EBSD的另一个核心目标是提供个性化的 为CCMBM社区提供咨询服务（目标2）。核心将增加获得和使用研究 设计、生物统计、数据管理和相关咨询，利用核心资源和杠杆作用 UCSF临床和转化科学研究所（CTSI）咨询服务（目标2a）。当它这样做时，核心 还将加强以病人为导向的临床研究，在肌肉骨骼健康在加州大学旧金山分校创建一个 创新的“研究实施辅导”服务，针对初级研究人员和其他新进入该领域的人员 (Aim 2b）。为了进一步扩大核心的影响力，核心主任和联席主任将加强 在临床科室和研究小组内进行肌肉骨骼研究的机会， 在这些群体中嵌入流行病学家（目标2c）。最后，EBSD核心将 教育CCMBM社区（目标3），培训研究者良好的研究设计和执行实践 在分析方法方面，最大限度地提高他们工作的严谨性和有效性。这将涉及到小说的创作， 专门为肌肉骨骼研究者量身定制的教育模块，包括基础和 翻译研究者（目标3a）。核心课程还将通过以下方式增加获得和使用正式课程的机会： CCMBM成员通过利用UCSF临床研究和骨质疏松持续医学培训 教育项目。在实现这些目标的过程中，EBSD核心将为CCMBM成员提供服务。 从工作台到床边的连续性，提高生产力并促进肌肉骨骼领域的合作 研究社区。