Epidemiology and Biostatisctics

我们提出了一个流行病学和生物统计学核心，将提供给CCMBM调查人员的数据 来自NIAMS和其他来源支持的大量研究。这些研究包括 超过10万名男性和女性的临床数据、图像和生物样本， 人年。核心基金目前每年收到约20，000，000美元的骨和关节总费用 其中约60%来自NIAMS。EB核心还将提供研究设计方面的咨询 以及生物统计学和临床研究项目设计和实施的教育。具体目标 核心内容如下：（1）。为UCSF骨质疏松症和骨关节炎研究社区提供大型纵向数据库，包括相关的生物学和成像数据，这些数据将用于检验假设， 关于骨质疏松症和骨关节炎的发病机制、危险因素和诊断的技术。2）。在良好的研究设计和执行实践中培训UCSF骨和关节研究人员，以最大限度地提高他们工作的严谨性和有效性。3）。为遗传学和基因组学数据集提供数据分析服务和咨询。4）。为加州大学旧金山分校的CCMBM社区提供咨询，以设计和分析NIH资助的项目和提案以及CCMBM资助的试点研究。5）。为了鼓励更强的联系，并作为一个管道之间的合作基础，转化和临床研究在骨和关节在UCSF。核心将由Dennis Black博士和Michael Nevitt博士共同指导，并将建立在与CCMBM成员（例如放射学，骨科手术和内分泌学）的现有合作基础上，以设计新的研究，提高现有NIAMS基金资源的价值。拟议的CCMBM将通过刺激基础和临床科学家之间的合作产生很大的临床影响，否则将不存在。这是一个令人兴奋和独特的机会，利用广大的骨质疏松症和骨关节炎， 资源，在加州大学旧金山分校，以解决新的问题，并扩大骨和联合研究社区。

We propose an Epidemiology and Biostatistics Core that will make available to CCMBM investigators data from a large number of studies that are supported by NIAMS and other sources. These studies include clinical data, images, and biological samples on over 100,000 men and women followed for over 1,000,000 person years. The Core currently receives about $20,000,000 per year in total costs for bone and joint projects of which about 60% in from NIAMS. The EB Core would also provide consulting on study design and biostatistics and education of design and implementation of clinical research projects. The specific aims of the Core are as follows: 1). To make available to the UCSF osteoporosis and osteoarthritis research community large, longitudinal databases including associated biological and imaging data that will be used to test hypotheses and techniques regarding the pathogenesis, risk factors, and diagnosis of osteoporosis and osteoarthritis. 2). To train UCSF bone and joint researchers in good study design and execution practices to maximize the rigor and validity of their work. 3). To provide data analysis services and consultation for genetics and genomics data sets. 4). To provide to the CCMBM community at UCSF consulting in the design and analysis of NIH-funded projects and proposals as well as pilot studies funded by CCMBM. 5). To encourage stronger ties and to serve as a conduit for collaborations between basic, translational, and clinical research in bone and joints at UCSF. The Core will be Co-Directed by Dennis Black, PhD and Michael Nevitt, PhD, and will build on existing collaborations with CCMBM members, (e.g. radiology, orthopaedic surgery, and endocrinology) to design new studies that enhance the value of existing NIAMS fund resources. The proposed CCMBM will have high clinical impact by stimulating collaborations between basic and clinical scientists that would not otherwise exist. This is an exciting and unique opportunity to leverage the vast osteoporosis and osteoarthritis resources, at UCSF to address new questions and expand the bone and joint research community.