CVM Vet-LIRN Veterinary Diagnostic Laboratory Program (U18)

项目总结 在美国，食源性疾病每年都会导致严重的发病率和死亡率。 尽管人类的食源性疾病通常与食用受污染的 食物、宠物可能是包括沙门氏菌在内的细菌病原体的直接和间接来源， 弯曲杆菌和李斯特氏菌。美国食品和药物管理局(FDA)兽医实验室 调查响应网络(VET-LIRN)兽医诊断实验室合作 协议计划旨在通过为人类和动物提供科学的 为日常和应急响应提供信息和建设实验室能力 疾病暴发调查，病原菌抗药性信息 从兽医病人身上分离出来，并调查动物饲料和药物的问题。 疫情的检测需要从地理上不同的地区收集样本的能力。 得克萨斯州有2900万人口，人口仅次于加利福尼亚州，位居榜首 这个国家的马和牛的数量都很多。因此，了解动态是很重要的 在德克萨斯州的动物和人中传播食源性疾病。德克萨斯A&M 这所大学是德克萨斯州历史最悠久、历史最悠久的兽医学院的所在地。这个 德克萨斯农工大学兽医教学医院临床微生物学实验室 目前担任FDA Vet-LIRN实验室。实验室的成员们帮助完成了 开发Vet-LIRN方法检测沙门氏菌和空肠弯曲杆菌，参与 能力测试，收集和分析样本，作为Vet-LIRN调查的一部分；以及 为Vet-LIRN正在进行的鉴定抗菌素耐药性的工作提供了分离物 通过全基因组测序从兽医患者身上提取病原体。这样做的目的是 提案是在德克萨斯州提供基础设施，以支持从 宠物支持FDA Vet-LIRN通过Prompt保护人类和动物健康的使命 识别疫情，检测与疫情有关的样本，以及 VET-LIRN计划办公室需要的监视任务。

PROJECT SUMMARY Foodborne illness causes significant morbidity and mortality each year in the United States. Although human foodborne illness is usually associated with the consumption of contaminated food, pets can be direct and indirect sources of bacterial pathogens including Salmonella, Campylobacter, and Listeria. The Food and Drug Administration (FDA) Veterinary Laboratory Investigation Response Network (Vet-LIRN) Veterinary Diagnostic Laboratory Cooperative Agreement Program is designed to promote human and animal health by providing scientific information and building laboratory capacity for routine and emergency response for investigation of outbreaks of disease, information on antimicrobial resistance in pathogens isolated from veterinary patients, and to investigate problems with animal feeds and drugs. Detection of outbreaks requires the ability to collect samples from geographically diverse areas. Texas is home to 29 million people, second only to California in human population, and leads the nation in horse and cattle populations. It is therefore important to understand the dynamics of foodborne diseases among animals and people within the State of Texas. Texas A&M University is home to the oldest, established College of Veterinary Medicine in Texas. The Texas A&M University Veterinary Medical Teaching Hospital Clinical Microbiology Laboratory currently serves as an FDA Vet-LIRN Laboratory. Members of the laboratory have helped to develop Vet-LIRN methods for detection of Salmonella and Campylobacter jejuni, participated in proficiency testing, collected and analyzed samples as part of Vet-LIRN investigations, and provided isolates for the Vet-LIRN ongoing effort to characterize the antimicrobial resistance in pathogens from veterinary patients through whole genome sequencing. The objective of this proposal is to provide infrastructure in Texas to support collection and testing of samples from pets to support the FDA Vet-LIRN mission of protecting human and animal health by prompt recognition of outbreaks and testing of samples associated with outbreaks as well as surveillance assignments as needed by the Vet-LIRN Program Office.