CVM Vet-LIRN Veterinary Diagnostic Laboratory Program (U18)

CVM Vet-LIRN 兽医诊断实验室计划 (U18)

• 批准号: 10641928
• 负责人: Sara D. Lawhon
• 金额: $ 4.55万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641928
• 关键词: CVM; Vet; LIRN; Veterinary; Diagnostic

PROJECT SUMMARY Foodborne illness causes significant morbidity and mortality each year in the United States. Although human foodborne illness is usually associated with the consumption of contaminated food, pets can be direct and indirect sources of bacterial pathogens including Salmonella, Campylobacter, and Listeria. The Food and Drug Administration (FDA) Veterinary Laboratory Investigation Response Network (Vet-LIRN) Veterinary Diagnostic Laboratory Cooperative Agreement Program is designed to promote human and animal health by providing scientific information and building laboratory capacity for routine and emergency response for investigation of outbreaks of disease, information on antimicrobial resistance in pathogens isolated from veterinary patients, and to investigate problems with animal feeds and drugs. Detection of outbreaks requires the ability to collect samples from geographically diverse areas. Texas is home to 29 million people, second only to California in human population, and leads the nation in horse and cattle populations. It is therefore important to understand the dynamics of foodborne diseases among animals and people within the State of Texas. Texas A&M University is home to the oldest, established College of Veterinary Medicine in Texas. The Texas A&M University Veterinary Medical Teaching Hospital Clinical Microbiology Laboratory currently serves as an FDA Vet-LIRN Laboratory. Members of the laboratory have helped to develop Vet-LIRN methods for detection of Salmonella and Campylobacter jejuni, participated in proficiency testing, collected and analyzed samples as part of Vet-LIRN investigations, and provided isolates for the Vet-LIRN ongoing effort to characterize the antimicrobial resistance in pathogens from veterinary patients through whole genome sequencing. The objective of this proposal is to provide infrastructure in Texas to support collection and testing of samples from pets to support the FDA Vet-LIRN mission of protecting human and animal health by prompt recognition of outbreaks and testing of samples associated with outbreaks as well as surveillance assignments as needed by the Vet-LIRN Program Office.

项目摘要 在美国，食源性疾病每年都会导致显著的发病率和死亡率。 虽然人类食源性疾病通常与食用受污染的 食物，宠物可以是细菌病原体的直接和间接来源，包括沙门氏菌， 弯曲杆菌和李斯特菌。美国食品药品监督管理局（FDA）兽医实验室 调查反应网络（Vet-LIRN） 协议计划旨在通过提供科学的， 信息和建立实验室能力，以便对 疾病暴发调查，病原体耐药性信息 与兽医患者隔离，并调查动物饲料和药物的问题。 检测疫情需要有能力从地理上不同的地区收集样本。 德克萨斯州拥有2900万人口，人口仅次于加州， 全国的马和牛数量。因此，重要的是要了解动态 在德克萨斯州的动物和人群中发生的食源性疾病。德克萨斯A&M 大学是德克萨斯州最古老的兽医学院的所在地。的 德克萨斯A&M大学兽医教学医院临床微生物学实验室 目前是FDA Vet-LIRN实验室。实验室的成员帮助 开发用于检测沙门氏菌和空肠弯曲菌的Vet-LIRN方法，参与 作为Vet-LIRN调查的一部分，进行能力验证，采集和分析样本，以及 为Vet-LIRN提供分离株，以表征 通过全基因组测序从兽医患者身上提取病原体。的目的 一项提案是在得克萨斯州提供基础设施，以支持收集和测试来自 支持FDA Vet-LIRN的使命，即通过及时 确认疫情和检测与疫情有关的样本，以及 Vet-LIRN计划办公室需要的监督任务。

项目成果

Draft Genome Sequence of Erysipelothrix rhusiopathiae, Isolated from a Canine Case of Diskospondylitis.

从犬椎间盘炎病例中分离出红斑丹毒丝菌的基因组序列草案。

• DOI: 10.1128/mra.00592-20
• 发表时间: 2020
• 期刊: Microbiology resource announcements
• 影响因子: 0.8
• 作者: Little,SaraV;Hillhouse,AndrewE;Lawhon,SaraD
• 通讯作者: Lawhon,SaraD

Whole-Genome Sequences of an Abortive Bacillus safensis Strain Isolated from a Mare's Uterus.

从母马子宫中分离出的流产萨法芽孢杆菌菌株的全基因组序列。

• DOI: 10.1128/mra.00342-20
• 发表时间: 2020
• 期刊: Microbiology resource announcements
• 影响因子: 0.8
• 作者: Little,SaraV;Hillhouse,AndrewE;Lawhon,SaraD
• 通讯作者: Lawhon,SaraD