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Advanced Knee ASL Imaging at 7T

7T 先进膝关节 ASL 成像

基本信息

批准号：
10644152
负责人：
Xiufeng Li
金额：
$ 56.15万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10644152
关键词：
Address Adipocytes Adolescent Adult Affect Algorithms Blood Blood capillaries Blood flow Bone Development Bone Marrow Brain Clinical Clinical Research Communities Custom Diagnosis Diagnostic Disease Disease Progression Echo-Planar Imaging Etiology Family Functional disorder Goals Healthcare Image Imaging technology Knee Knee bone Knowledge Lesion Libraries Logistic Regressions Magnetic Resonance Imaging Measures Methodology Methods Modeling Monitor Noise Nomograms Osteochondritis Dissecans Patients Performance Perfusion Physiologic pulse Physiological Physiology Play Population Prognosis RF coil ROC Curve Research Role Safety Signal Transduction Slice Techniques Therapy Evaluation Time Tissue Viability Tissues Treatment Efficacy Uncertainty arterial spin labeling bone bone repair design disease diagnosis efficacy evaluation healing human model imaging modality imaging platform imaging study imaging system improved magnetic field novel prognostic performance research study response skeletal disorder software systems tool treatment response virtual virtual model

项目摘要

Abstract Bone marrow perfusion can provide essential knowledge about bone physiology, improve our understanding of disease etiology and pathophysiology, assist the differentiation between normal and abnormal bone marrow, and assess the response to prescribed therapies. Arterial spin labeling (ASL) magnetic resonance imaging (MRI), as a noninvasive and non-contrast-enhanced approach, is well suited for longitudinal monitoring of disease progression and routine evaluation of therapy response. But ASL imaging of knee epiphyseal bone marrow is challenging because ASL imaging is a low signal-to-noise ratio technique, and the perfusion level is significantly low in epiphyseal yellow bone marrow mainly consisting of fat cells with a sparse network of capillaries. Ultrahigh (≥7T) magnetic field can specifically benefit ASL imaging and overcome these challenges by increasing SNR, prolonging blood and tissue T1, and improving parallel imaging performance. However, the current clinically approved single-transmit MRI system and associated imaging methods are incapable of managing the transmit B1 (B1+) fields needed to realize the promised improvement in imaging quality, reliability, and robustness of 7T while existing RF coils are unable to provide adequate B1+ coverage for optimal ASL imaging. Our long-term goal is to develop and improve UHF imaging methods to better facilitate scientific research and clinical studies to improve the management of skeletal diseases and patient healthcare. The rationale is that the existing technical challenges for UHF imaging, including ASL, can be overcome or mitigated, ultimately to realize UHF potentials with promised benefits and superior imaging ability. The objective of this proposal is to develop and establish an optimized, safe, and efficient parallel transmit (pTx) platform for new pTx-integrated knee ASL imaging methods and explore their clinical potentials in juvenile osteochondritis dissecans (JOCD) patients. We will develop an optimized, safe, and efficient pTx platform for knee ASL imaging by developing a novel 32-channel loop-dipole transmit and receive array knee coil, building a VOP library using 13 human models from the Virtual Family (including morphed models) and evaluating alternative strategies for highly efficient knee ASL imaging, such as utilizing population-matched safety factors for adults and juveniles, respectively. We will develop and optimize pTx-integrated knee ASL imaging methods that will utilize optimized pTx RF pulses. We will also explore the clinical potentials of 7T knee ASL imaging in JOCD in terms of its ability in predicting 6- and 12-month healing status and differentiating patients with and without stable lesions and evaluate the diagnostic and prognostic performance of bone marrow blood flow measures using receiver operating characteristics (ROC) curve analyses. We will also develop a novel multivariate logistic regression model with a new nomogram to predict the healing status after 6, 12 months of nonoperative treatment.

摘要骨髓灌注可以提供有关骨生理学的基本知识，提高我们对疾病病因学和病理生理学，帮助区分正常和异常骨髓，并评估对处方治疗的反应。动脉自旋标记（ASL）磁共振成像 (MRI)作为一种非侵入性和非对比增强的方法，非常适合于纵向监测疾病进展和治疗反应的常规评价。但是膝关节骨骺的ASL成像骨髓是具有挑战性的，因为ASL成像是一种低信噪比技术，灌注水平是骨骺黄色骨髓显著低，主要由脂肪细胞组成，毛细血管。超高（≥ 7 T）磁场可特别有利于ASL成像并克服这些挑战通过增加SNR、延长血液和组织T1以及改善并行成像性能。但当前临床批准的单发射MRI系统和相关成像方法无法 - 管理实现成像质量、可靠性和7 T的稳健性，而现有的RF线圈无法提供足够的B1+覆盖，以实现最佳ASL 显像我们的长期目标是开发和改进超高频成像方法，以更好地促进科学研究和临床研究，以改善骨骼疾病的管理和病人的保健。基本原理是现有的超高频成像技术挑战，包括超高频激光，是可以克服或减轻的，最终实现超高频潜力，具有承诺的效益和上级成像能力。这项建议的目的是开发和建立一个优化的，安全的，高效的并行传输（pTx）平台，用于新的pTx集成幼年剥脱性骨软骨炎膝关节ASL成像方法及其临床应用价值患者我们将通过开发一种用于膝关节ASL成像的优化、安全和高效的pTx平台，新型32通道环形偶极子发射和接收阵列膝关节线圈，使用13个人体模型建立VOP库从虚拟家庭（包括变形模型）和评估替代战略， ASL成像，例如分别使用成人和青少年的人群匹配安全系数。我们将开发并优化pTx集成膝关节ASL成像方法，该方法将利用优化的pTx RF脉冲。我们还将探索7 T膝关节ASL成像在JOCD中预测6-和 12-月愈合状态和区分有和无稳定病变的患者，并评估诊断使用受试者工作特征（ROC）进行骨髓血流测量的预后性能曲线分析我们还将开发一种新的多变量逻辑回归模型，预测非手术治疗后6、12个月的愈合情况。