Advanced Knee ASL Imaging at 7T
7T 先进膝关节 ASL 成像
基本信息
- 批准号:10644152
- 负责人:
- 金额:$ 56.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdipocytesAdolescentAdultAffectAlgorithmsBloodBlood capillariesBlood flowBone DevelopmentBone MarrowBrainClinicalClinical ResearchCommunitiesCustomDiagnosisDiagnosticDiseaseDisease ProgressionEcho-Planar ImagingEtiologyFamilyFunctional disorderGoalsHealthcareImageImaging technologyKneeKnee boneKnowledgeLesionLibrariesLogistic RegressionsMagnetic Resonance ImagingMeasuresMethodologyMethodsModelingMonitorNoiseNomogramsOsteochondritis DissecansPatientsPerformancePerfusionPhysiologic pulsePhysiologicalPhysiologyPlayPopulationPrognosisRF coilROC CurveResearchRoleSafetySignal TransductionSliceTechniquesTherapy EvaluationTimeTissue ViabilityTissuesTreatment EfficacyUncertaintyarterial spin labelingbonebone repairdesigndisease diagnosisefficacy evaluationhealinghuman modelimaging modalityimaging platformimaging studyimaging systemimprovedmagnetic fieldnovelprognostic performanceresearch studyresponseskeletal disordersoftware systemstooltreatment responsevirtualvirtual model
项目摘要
Abstract
Bone marrow perfusion can provide essential knowledge about bone physiology, improve our understanding of
disease etiology and pathophysiology, assist the differentiation between normal and abnormal bone marrow,
and assess the response to prescribed therapies. Arterial spin labeling (ASL) magnetic resonance imaging
(MRI), as a noninvasive and non-contrast-enhanced approach, is well suited for longitudinal monitoring of
disease progression and routine evaluation of therapy response. But ASL imaging of knee epiphyseal bone
marrow is challenging because ASL imaging is a low signal-to-noise ratio technique, and the perfusion level is
significantly low in epiphyseal yellow bone marrow mainly consisting of fat cells with a sparse network of
capillaries. Ultrahigh (≥7T) magnetic field can specifically benefit ASL imaging and overcome these challenges
by increasing SNR, prolonging blood and tissue T1, and improving parallel imaging performance. However, the
current clinically approved single-transmit MRI system and associated imaging methods are incapable of
managing the transmit B1 (B1+) fields needed to realize the promised improvement in imaging quality, reliability,
and robustness of 7T while existing RF coils are unable to provide adequate B1+ coverage for optimal ASL
imaging.
Our long-term goal is to develop and improve UHF imaging methods to better facilitate scientific research
and clinical studies to improve the management of skeletal diseases and patient healthcare. The rationale is that
the existing technical challenges for UHF imaging, including ASL, can be overcome or mitigated, ultimately to
realize UHF potentials with promised benefits and superior imaging ability. The objective of this proposal is to
develop and establish an optimized, safe, and efficient parallel transmit (pTx) platform for new pTx-integrated
knee ASL imaging methods and explore their clinical potentials in juvenile osteochondritis dissecans (JOCD)
patients.
We will develop an optimized, safe, and efficient pTx platform for knee ASL imaging by developing a
novel 32-channel loop-dipole transmit and receive array knee coil, building a VOP library using 13 human models
from the Virtual Family (including morphed models) and evaluating alternative strategies for highly efficient knee
ASL imaging, such as utilizing population-matched safety factors for adults and juveniles, respectively. We will
develop and optimize pTx-integrated knee ASL imaging methods that will utilize optimized pTx RF pulses. We
will also explore the clinical potentials of 7T knee ASL imaging in JOCD in terms of its ability in predicting 6- and
12-month healing status and differentiating patients with and without stable lesions and evaluate the diagnostic
and prognostic performance of bone marrow blood flow measures using receiver operating characteristics (ROC)
curve analyses. We will also develop a novel multivariate logistic regression model with a new nomogram to
predict the healing status after 6, 12 months of nonoperative treatment.
摘要
骨髓灌注可以提供有关骨生理学的基本知识,提高我们对
疾病病因学和病理生理学,帮助区分正常和异常骨髓,
并评估对处方治疗的反应。动脉自旋标记(ASL)磁共振成像
(MRI)作为一种非侵入性和非对比增强的方法,非常适合于纵向监测
疾病进展和治疗反应的常规评价。但是膝关节骨骺的ASL成像
骨髓是具有挑战性的,因为ASL成像是一种低信噪比技术,灌注水平是
骨骺黄色骨髓显著低,主要由脂肪细胞组成,
毛细血管。超高(≥ 7 T)磁场可特别有利于ASL成像并克服这些挑战
通过增加SNR、延长血液和组织T1以及改善并行成像性能。但
目前临床上批准的单发射MRI系统和相关成像方法不能
- 管理实现成像质量、可靠性
和7 T的稳健性,而现有的RF线圈无法提供足够的B1+覆盖,以实现最佳ASL
显像
我们的长期目标是开发和改进超高频成像方法,以更好地促进科学研究
和临床研究,以改善骨骼疾病的管理和病人的保健。基本原理是
现有的超高频成像技术挑战,包括超高频激光,是可以克服或减轻的,最终
实现超高频潜力,具有承诺的效益和上级成像能力。这项建议的目的是
开发和建立一个优化的,安全的,高效的并行传输(pTx)平台,用于新的pTx集成
幼年剥脱性骨软骨炎膝关节ASL成像方法及其临床应用价值
患者
我们将通过开发一种用于膝关节ASL成像的优化、安全和高效的pTx平台,
新型32通道环形偶极子发射和接收阵列膝关节线圈,使用13个人体模型建立VOP库
从虚拟家庭(包括变形模型)和评估替代战略,
ASL成像,例如分别使用成人和青少年的人群匹配安全系数。我们将
开发并优化pTx集成膝关节ASL成像方法,该方法将利用优化的pTx RF脉冲。我们
还将探索7 T膝关节ASL成像在JOCD中预测6-和
12-月愈合状态和区分有和无稳定病变的患者,并评估诊断
使用受试者工作特征(ROC)进行骨髓血流测量的预后性能
曲线分析我们还将开发一种新的多变量逻辑回归模型,
预测非手术治疗后6、12个月的愈合情况。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee.
- DOI:10.1055/s-0043-1775741
- 发表时间:2023-12
- 期刊:
- 影响因子:1.4
- 作者:
- 通讯作者:
Editorial for "Significance of Normalized Apparent Diffusion Coefficient in the Vesical Imaging-Reporting and Data System for Diagnosing Muscle-Invasive Bladder Cancer".
“膀胱成像报告和数据系统中标准化表观扩散系数对于诊断肌肉浸润性膀胱癌的意义”的社论。
- DOI:10.1002/jmri.29233
- 发表时间:2024
- 期刊:
- 影响因子:0
- 作者:Li,Xiufeng
- 通讯作者:Li,Xiufeng
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