Catalyzing and Harmonizing Operational Innovation for Recruitment (CHOIR)

促进和协调招聘运营创新 (CHOIR)

• 批准号: 10649341
• 负责人: Paul A. Harris
• 金额: $ 535.76万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-14 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649341
• 关键词: Adopted; Area; Attention; Awareness; Benefits and Risks; Clinical Data; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Communities; Compensation; Complex; Consultations; Development; Disease; Disparity; Disparity population; Doctor of Philosophy; Education; Elements; Eligibility Determination; Enrollment; Ensure; Equity; Fast Healthcare Interoperability Resources; Funding; Geography; Goals; Home; Informatics; Informed Consent; Infrastructure; Language; Media Campaign; Methods; Minority Groups; Minority Recruitment; Mission; Monitor; Participant; Population; Population Heterogeneity; Procedures; Recommendation; Recruitment Activity; Research; Resources; Site; Testing; Time; Training; Translation Process; Trust; Underrepresented Populations; United States National Institutes of Health; Voice; Work; clinical trial recruitment; community engagement; cost; data resource; data tools; design; disenfranchised population; electronic consent; evidence based guidelines; health equity; human disease; improved; innovation; mobile computing; operation; recruit; screening; skill acquisition; skills; social media; success; synergism; tool; trial design; usability

While recruitment into clinical research has been a longstanding challenge for NIH funded multi-site studies, it has become clear that there is substantial variability in recruitment success across the national portfolio caused by many factors: eligibility parameters, required procedures, compensation levels, engagement practices, recruitment resources, skill and awareness of recruitment teams, geographic constraints, trust, and perceived benefit/risk. Studies that do not integrate these factors into recruitment and retention often close for poor accrual. In addition, there are now more equitable definitions of what constitutes “recruitment success” beyond an absolute target, including: diversity, representativeness of the actual population, costs of enrollment, retention, and time required. These complex dynamics suggest there is no ‘one size fits all’ solution, and careful attention and consideration must be a part of the recruitment plan. Our team has been forming effective recruitment collaborations for the past 6 years -- considering the study specifics, capabilities of the study team, and needs and values of the participant population -- to together craft feasible, effective plans. In the next cycle, we will Catalyze and Harmonize Operational Innovation for Recruitment (CHOIR) and will continue to be led by a long-standing synergistic partnership between Paul Harris, PhD, as PI responsible for informatics development, and Consuelo Wilkins, MD, MSCI, as PI of community and stakeholder engagement. Formal partnerships with 10 other CTSAs provide broad understanding of Hub needs, along with key areas of expertise. We will extend and build upon existing recruitment-related assets and data tools and resources already in use by our team and others (FasterTogether, ResearchMatch, REDCap TrialsToday, FHIR clinical data-based recruitment infrastructure). These innovations acknowledge recruitment is not a one-time activity but is a continuum. We will provide a national, disease agnostic home for sharing recruitment tools, training, materials, and best practices for diverse populations. Specific Aims are: 1) Partner with study teams to create study-specific recruitment plans, and support ongoing skills development. 2) Evaluate clinical trial recruitment and retention methods and make continual improvements. 3) Enhance national clinical trial awareness through engagement and education; facilitate participant identification of studies with online tools. And, 4) Develop and disseminate technical and procedural approaches to catalyze enrollment in clinical trials across all CTSAs.

虽然招募临床研究人员一直是美国国立卫生研究院资助的多地点研究的长期挑战，