Molecular and cellular basis of mosquito olfactory attraction to hay infusion for enhanced vector surveillance and control
蚊子对干草浸液的嗅觉吸引力的分子和细胞基础,以加强病媒监测和控制
基本信息
- 批准号:10648584
- 负责人:
- 金额:$ 24.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-18 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AdhesivesAedesAfferent NeuronsAfricanAnalytical ChemistryArbovirusesBehaviorBehavioralBehavioral AssayBiological AssayBloodBotanicalsCessation of lifeChemicalsChemoreceptorsConstitutionConstitutionalCulicidaeCynodonDataDengueDesiccationDevelopmentDisease VectorsEngineeringFemaleFermentationFormulationFutureGeneticGoalsGrantGravidHeterozygoteHumanInfusion proceduresLaboratoriesLigandsMediatingMethodsMolecularMolecular TargetNeuronsOlfactory PathwaysOvipositionPartner in relationshipPathway interactionsPhysiologicalPlayPopulationPopulation ControlPopulation DynamicsPopulation SurveillancePuerto RicoResearchResistanceReverse engineeringRoleSearching BehaviorSensorySeriesSiteSourceTestingWaterYellow FeverZIKAbehavior testcell typeeggfeedingfield studyimprovedinsightloss of functionmanmutantneuralneural circuitneurophysiologynovelolfactory sensory neuronspreferencepregnantreceptorresponsetoolurban settingvectorvolatile organic compound
项目摘要
The mosquito Aedes aegypti is a prolific disease vector that thrives in urban environments. Its explosive
population dynamics are driven by the ability of female Ae. aegypti to seek out standing pools of water to lay
their desiccation-resistant eggs. Of note, females are attracted to the scent of decomposing botanical matter in
water, but only after mating and blood-feeding. In particular, gravid female Ae. aegypti are highly attracted to
the scent of fermenting African Bermuda grass hay in water, which has been exploited for mosquito trapping
strategies in the field that aim to lure this major disease vector to its death during the act of egg laying. We
propose to apply integrative methods to define the molecular and cellular basis of Ae. aegypti olfactory
attraction to hay infusion which will catalyze identification of olfactory circuitry mediating oviposition site search
and novel oviposition attractants for this disease vector. To elucidate candidate chemoreceptors and
associated neurons implicated in mosquito olfactory attraction to hay infusion, we will test the role of different
chemoreceptor classes using loss-of-function genetics and olfactory sensory neuron populations by selectively
disrupting neural activity using cell-type specific neuronal silencing. In parallel, we aim to reverse engineer
attractive blends of oviposition attractants mimicking the scent of hay infusion by leveraging chemical analysis
of infusion headspace combined with neural activity assays that compare olfactory sensitivity and response
amplitudes of non-gravid and gravid mosquitoes to conserved volatile organic compounds found in this this
natural lure. These aims will fundamentally improve our understanding of the chemosensory basis of Ae.
aegypti oviposition site search behavior. From a translational perspective, this research will reveal new
molecular targets in the Ae. aegypti olfactory system to modulate mosquito egg laying behavior and identify
novel synthetic formulations of oviposition attractants for enhanced population surveillance and control of this
globally important disease vector.
埃及伊蚊是一种多产的病媒,在城市环境中大量繁殖。其爆炸
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Conor James McMeniman其他文献
Conor James McMeniman的其他文献
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{{ truncateString('Conor James McMeniman', 18)}}的其他基金
Molecular Architecture of the Mosquito Carbon Dioxide Receptor Complex
蚊子二氧化碳受体复合物的分子结构
- 批准号:
9808786 - 财政年份:2019
- 资助金额:
$ 24.12万 - 项目类别:
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