Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
基本信息
- 批准号:10044350
- 负责人:
- 金额:$ 20.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2022-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAmericanApcMin/+ miceAppearanceAzoxymethaneBiologicalBlood VesselsBrightfield MicroscopyCancer ControlCarcinogensCell physiologyCellsCellular biologyClinicClinicalColonColonic PolypsColonoscopyColorectal CancerComputer AssistedComputer softwareDNA analysisDataData AnalysesDescriptorDetectionDevelopmentDiagnosticDiffusion Magnetic Resonance ImagingDiseaseDistalDistantDoctor of MedicineEarly DiagnosisEndoscopyEnsureEquipmentEventExcisionFDA approvedFamily PracticeFecesFlexible fiberoptic sigmoidoscopyGenetic ModelsGoldHealthHomeostasisHumanHuman ResourcesImageImage AnalysisImmuneInterventionIntestinal PolyposisIntestinesLaboratoriesLesionLow incomeMalignant NeoplasmsMaster of Public HealthMeasuresMedicalMethodsMicroscopyModalityModelingMorbidity - disease rateMorphologyMusPatientsPerformancePhysiciansPilot ProjectsPolypsPopulationPre-Clinical ModelPrecancerous PolypPreventionPreventive MedicinePrimary Health CareProceduresProcessRetrievalSamplingScheduleSentinelSlideSpecificitySpecimenStainsStandardizationStructureSwabTechnologyTestingTissuesTrainingValidationWild Type Mouseadenomaadherence ratebasecancer geneticscancer preventioncarcinogenesisclinical practicecolorectal cancer preventioncolorectal cancer screeningcomplex data computer aided detectioncomputer data analysiscomputerizedcostcost effectivedesigndextran sulfate sodium induced colitisdigitalearly onsetequipment traininghuman tissueimaging modalityimprovedinnovationintestinal epitheliummast cellmedical schoolsminimally invasivemortalitymouse modelneoplasticpre-clinicalpreclinical studypremalignantpreservationpreventprimary care settingprismaprocedure costprofessorprogramsquantitative imagingrectalsample collectionscreeningtumor progressionuptakevalidation studies
项目摘要
SUMMARY
Screening remains the key intervention for colorectal cancer (CRC) control and prevention as detection and
removal of premalignant lesions can prevent progression to cancer. Colonoscopy, the gold standard for CRC
screening, is an invasive and costly procedure resulting in low compliance in both the general and the under-
screened populations, including low-income and early-onset young patients. Feces-screening methods also
suffer low compliance rates. Affordable and minimally invasive approaches are urgently warranted to address
low screening rates and prevent CRC through early detection. We are proposing to explore the concept of field
effect in CRC or simultaneous occurrence of subtle alterations distal from precancerous polyps in the colon, in
an innovative way, to develop a new screening modality for CRC. Mast cells (MC) are innate immune cells
located close to the intestinal epithelium and blood vessels at homeostasis, whose accumulation is an
essential feature of intestinal polyposis in mice and of invasive intestinal lesions. We hypothesized that MC
might slough off in the colonic lumen upon precancerous transformation, but not in normal healthy cases, thus
being accessible by rectal swabbing, together with other cells. Combining our dual expertise in quantitative
imaging and mast cell (MC) biology, we surmise that swab-collected cells might be analyzed on microscopy
slides after processing and staining for MC using bright-field microscopy and image analysis software. Our
preliminary results using two preclinical models of CRC, the genetic ApcMin/+ mouse model and the
azoxymethane/dextran sulfate sodium-induced colitis leading to CRC, indicate the presence of swab MC in
polyp carrying but not in healthy polyp-free, inflamed polyp-free, cancer-free or wild type mice. To ensure
standardized sample analysis, we propose to develop a computational imaging method for swab MC detection
by integrating MC-restricted morphometric descriptors. Further biological and technical validations will be
performed. If confirm, our working hypothesis will be tested in a human pilot study.
总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CAROLE A OSKERITZIAN其他文献
CAROLE A OSKERITZIAN的其他文献
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{{ truncateString('CAROLE A OSKERITZIAN', 18)}}的其他基金
Novel modalities for prostate cancer screening: mast cells as predictors of disease, disease aggressiveness and marks of disease disparity
前列腺癌筛查的新方法:肥大细胞作为疾病、疾病侵袭性和疾病差异标志的预测因子
- 批准号:
10650620 - 财政年份:2023
- 资助金额:
$ 20.9万 - 项目类别:
Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
- 批准号:
10456820 - 财政年份:2020
- 资助金额:
$ 20.9万 - 项目类别:
Development of a noninvasive, rapid and affordable method for early detection of colorectal cancer
开发一种无创、快速且经济实惠的结直肠癌早期检测方法
- 批准号:
10174880 - 财政年份:2020
- 资助金额:
$ 20.9万 - 项目类别:
MicroRNAs in atopic dermatitis pathogenesis: a role for mast cell and sphingosine-1-phosphate?
MicroRNA 在特应性皮炎发病机制中:肥大细胞和 1-磷酸鞘氨醇的作用?
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9035633 - 财政年份:2016
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48th Annual South Eastern Regional Lipid Conference (SERLC) Funding Support
第 48 届年度东南地区脂质会议 (SERLC) 资金支持
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8651999 - 财政年份:2013
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Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
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8730283 - 财政年份:2012
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$ 20.9万 - 项目类别:
Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
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Mast Cell S1P Receptor2 in the initiation and progression of chronic inflammation
肥大细胞S1P受体2在慢性炎症的发生和进展中的作用
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Sphingosine-1-Phosphate, A Novel Mediator of Human Skin Mass Cell Functions
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