T32 Predoctoral training grant in Glycosciences

此应用程序请求T32资金，以支持在化学-生物接口的博士前培训 佐治亚大学。该奖项将取代目前的T32血糖科学培训计划(GTP) 成立于2014年。GTP的使命是培养下一代糖科学研究人员和 为他们在生物医学劳动力中有影响力的职业生涯做好准备。2012年，美国国家科学院和 工程学发布的一份报告得出结论，美国对血糖科学的研究严重不足 各州并鼓励包括NIH在内的政府机构制定培训方案，以加快 在这一关键研究领域的发现。尽管多糖在生物学和医学中扮演着重要的角色，但没有 美国的其他T32培训项目侧重于多聚糖；因此，GTP扩大了NIH- 支持的培训计划。GTP利用独特的丰富环境进行碳水化合物研究 存在于佐治亚大学。来自8个部门的24名研究人员将担任培训员 面向不同的博士前学生群体。实习生是从进入 大学的研究生课程通过综合生命科学(ILS)伞形课程或通过 录取进入化学系。这笔补助金将每年为六名学员提供津贴，为期两年- 年度约会。该大学每年将为额外两名实习生提供资金，以扩大影响 是GTP的。该计划的主要目标是提供一个广泛的糖科学背景与 将这些知识运用到各种职业中的能力。训练强调科学推理、严谨 在研究设计、量化技能和数据分析方面。所有实习生都将报名参加职业发展 关于负责任的研究行为以及严谨、可重复性和透明度的课程，并采取 糖化学和糖生物学基础课程。所有这些课程都对任何学生开放， 将GTP的影响扩大到T32支持的受训人员之外。学员可从多种选项中进行选择 培养分析、计算或生物学方法方面的知识和技能的课程。机会将是 在课程、日记俱乐部和研讨会中培养良好的书面和口头沟通能力 程序。培训员将提供支持性、包容性和多样化的培训环境，并 致力于作为导师通过参加关于以下方面的研讨会和培训计划不断改进 诸如有效的指导、工作场所的安全空间和隐性偏见等话题。导师的有效性将是 使用最近对UGA上的T32和T25计划的补充拨款制定的指标进行评估 这些数据将指导GTP中导师的持续改进。我们将跟踪学生 结果并使用年度计划评估来做出基于证据的决策，以完善招聘和 培训实践。改进的指导和培训方法将广泛传播给影响毕业生 在全国范围内进行培训。

This application requests T32 funding to support pre-doctoral training at the chemistry-biology interface at the University of Georgia. This award will replace the current T32 Glycoscience Training Program (GTP) that was established in 2014. The mission of the GTP is to train the next generation of glycoscience researchers and prepare them for impactful careers in the biomedical workforce. In 2012 the National Academy of Sciences and Engineering issued a report concluding that the Glycosciences were significantly understudied in the United States and encouraged government agencies including the NIH to develop training programs to accelerate discovery in this critical research area. Despite the significant role that glycans play in biology and medicine, no other T32 training program in the United States focuses on glycans; thus, the GTP broadens the scope of NIH- supported training programs. The GTP capitalizes on the uniquely rich environment for carbohydrate research that exists at the University of Georgia. Twenty-four researchers from eight departments will serve as trainers for a diverse group of pre-doctoral students. Trainees are selected from a pool of applicants that enter the university’s graduate program either through the Integrated Life Sciences (ILS) umbrella program or through admission into the Department of Chemistry. The grant will provide stipends for six trainees per year for two- year appointments. The university will provide funding for two additional trainees per year to expand the impact of the GTP. The principal objective of this program is to provide a broad background in glycoscience with the ability to carry that knowledge forward into a variety of careers. Training emphasizes scientific reasoning, rigor in research design, quantitative skills, and data analysis. All trainees will enroll in professional development courses on the Responsible Conduct of Research and on Rigor, Reproducibility, and Transparency, and take foundational courses in Glycochemistry and Glycobiology. All of these courses are open to any student, broadening the impact of the GTP beyond the T32-supported trainees. Trainees can select from a variety of courses to build knowledge and skills in analytical, computational, or biological methods. Opportunities will be provided to develop strong written and oral communication skills in coursework, journal clubs, and seminar programs. The trainers will provide a supportive, inclusive, and diverse training environment, and are committed to continuous improvement as mentors through participation in workshops and training programs on topics such as effective mentoring, safe space in the workplace, and implicit bias. Mentor effectiveness will be evaluated using metrics developed with a recent supplemental grant to T32 and T25 programs on the UGA campus, and these data will guide the continuous improvement of mentoring in the GTP. We will track student outcomes and use annual program evaluations to make evidence-based decisions to refine recruiting and training practices. Improved methods for mentoring and training will be disseminated widely to impact graduate training on a national scale.