Fiber-rich Foods to Treat Obesity and Prevent Colon Cancer

富含纤维的食物可治疗肥胖和预防结肠癌

• 批准号: 10650165
• 负责人: Terryl J. Hartman
• 金额: $ 69.96万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650165
• 关键词: Adenomatous Polyps; African; African American population; Antineoplastic Agents; Apoptosis; Atherosclerosis; Behavior; Behavior Therapy; Bile Acids; Biochemical Markers; Biological; Biological Markers; Body Weight; Body Weight decreased; Body mass index; C-reactive protein; CD3 Antigens; Calories; Carcinogens; Cd68; Cell Proliferation; Chinese; Chronic; Chronic Disease; Colon; Colon Carcinoma; Colonoscopy; Colorectal Cancer; Communities; Consumption; Controlled Clinical Trials; Controlled Study; Depressed mood; Diet; Diet Modification; Dietary Intervention; Disease; Dryness; Education; Energy Intake; Epidemiology; Equilibrium; Fabaceae; Fasting; Fatty acid glycerol esters; Female; Fermentation; Fiber; Food; Gastroenterology; Gastrointestinal Motility; Gastrointestinal Transit; Germ-Free; Glucose; Goals; Health; High-Risk Cancer; Incidence; Inflammation; Inflammatory; Instruction; Insulin; Insulin Resistance; Intake; Intervention; Intervention Studies; Investigation; Lentils - dietary; Link; Lipids; Longterm Follow-up; Lymphocyte; Macrophage; Maintenance; Malignant Neoplasms; Measures; Mediating; Metabolic; Metabolic Diseases; Metabolic dysfunction; Methods; Microbe; Modification; Monitor; Mucous Membrane; Mus; Non-Insulin-Dependent Diabetes Mellitus; Nutritional; Obesity; Outcome; Overweight; Participant; Patients; Pattern; Phase; Phytochemical; Plants; Plasma; Polypectomy; Polyps; Population; Population Heterogeneity; Population Intervention; Populations at Risk; Production; Public Health; Publishing; Randomized; Recording of previous events; Reporting; Research; Risk; Risk Factors; Satiation; Science; Self Direction; Serum; Speed; Testing; Therapeutic; Time; Weight; Weight Gain; Weight maintenance regimen; adenoma; arm; bean; cancer biomarkers; cancer risk; carcinogenicity; colon cancer prevention; colon cancer risk; colorectal cancer risk; design; dietary; dietary control; experience; food consumption; gut microbiota; high risk; high risk population; insulin signaling; intervention participants; intraepithelial; male; metabolome; microbial; microbiome; microbiota; middle age; mortality; multimodality; nutrition; prevent; programs; randomized, clinical trials; recruit; response; systemic inflammatory response; volunteer; western diet

Project Summary/Abstract Obesity is a significant public health concern and a well-known risk factor for colorectal cancer (CRC). Western diet, high in calories and fat and deficient in fiber-rich foods, is a key driver of metabolic diseases like obesity and CRC. High-fiber diets including foods like legumes, such as dry beans and lentils, could have favorable effects on underlying biological responses that mediate the obesity-cancer relationship including insulin signaling, chronic inflammation, gastrointestinal motility, gut microbiota changes and the balance between cell proliferation and apoptosis. We propose to build upon our previous research demonstrating that short-term strictly monitored increases in fiber-rich food consumption facilitates weight loss and suppresses biomarkers of cancer risk. The goal of the current research is to conduct a 12-month parallel arm randomized clinical trial featuring pre-portioned entrées and strategic nutritional instruction to integrate legumes into a healthy high-fiber diet pattern. Over the course of the intervention participants will receive intense education combined with behavior modification, transitioning to self-directed and finally sustainable maintenance phases. The research will target a diverse population at highest risk for CRC (recruit n=70; 50% males / 50% females), overweight and obese participants with a history of polypectomy, to test whether a high-legume, high-fiber diet will increase weight loss and suppress colonic mucosal biomarkers of cancer risk compared to a control diet. In addition, we will explore potential beneficial effects of the high-legume intervention diet on the microbiome and metabolome, gastrointestinal transit time and on systemic biomarkers of inflammation and insulin resistance. Given the 20-fold differences in CRC between populations consuming high-fiber diets and low-fiber Western diets, the results of this study may demonstrate substantial potential for dietary change to reduce mortality from CRC and other westernized diseases.

项目总结/文摘

项目成果

Interactions between the environmental and human microbiota in the preservation of health and genesis of disease: symposium report.

环境与人类微生物群在保护健康和疾病发生方面的相互作用：研讨会报告。

• DOI: 10.1097/mog.0000000000000817
• 发表时间: 2022
• 期刊: Current opinion in gastroenterology
• 影响因子: 2.5
• 作者: Ramaboli,Matsepo;Nesengani,Lucky;Katsidzira,Leolin;Haller,Dirk;Kinross,James;Ocvirk,Soeren;O'Keefe,StephenJD; andtheAfricanMicrobiomeInternationalConsortium
• 通讯作者: andtheAfricanMicrobiomeInternationalConsortium