Emerging Infectious Diseases Research Center - East and Central Africa
新发传染病研究中心 - 东非和中非
基本信息
- 批准号:10649662
- 负责人:
- 金额:$ 120.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:AfricaAfrica South of the SaharaAfricanAgricultureAirAnimalsAsiaBerlinBirthCamelsCenters for Disease Control and Prevention (U.S.)Central AfricaCessation of lifeChinaCirculationClinicalClinical ResearchCollaborationsCommunicable DiseasesCommunitiesCongoCoronavirusCoronavirus InfectionsCountryCountyDemocratic Republic of the CongoDevelopmentDiagnosticDiseaseDisease OutbreaksDisease SurveillanceDromedariesEastern AfricaEbolaEmerging Communicable DiseasesEnvironmentEpidemicEuropeFoodFrequenciesGenotypeHealthHigh PrevalenceHospital ReferralsHumanIncidenceInfantInfectionInfectious Diseases ResearchInfluenzaInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N1 SubtypeInfrastructureInternationalKenyaKnowledgeLaboratoriesLife StyleLivestockLongitudinal cohort studyMaintenanceMarburgvirusMeasuresMiddle EastMiddle East Respiratory SyndromeMiddle East Respiratory Syndrome CoronavirusMorbidity - disease rateOccupationsOutpatientsPathogenicityPhenotypePhysiciansPilot ProjectsPopulationPredispositionPreventionPublic HealthReagentRecurrenceRegional DiseaseReportingResearchRift Valley FeverRift Valley fever virusRiskRisk AssessmentRoleSamplingScientistSeroprevalencesServicesSevere Acute Respiratory SyndromeSeveritiesSeverity of illnessSiteTanzaniaTelephoneTestingTravelTropical MedicineUgandaUnited StatesUniversitiesVeterinariansViralViral Hemorrhagic FeversViral reservoirVirulenceVirulentVirusVirus DiseasesVirus SheddingVisitWashingtonWorld Health OrganizationZIKAZoonosescohortcommunity livingdensityemerging pathogenexperiencefield studyfollow-upforestglobal healthhealth care availabilityhealth seeking behaviorhuman diseaseimprovedinfluenza epidemicmarginalizationmarginalized communitymortalityoutbreak responsepathogenphysical conditioningprogramsrespiratoryresponsesocial culturetranslational studytransmission processvectorviral detectionviral outbreakviral transmission
项目摘要
PROJECT SUMMARY
Since 2012 when the first human case of Middle East respiratory syndrome coronavirus (MERS-CoV) was
confirmed, the World Health Organization has reported >2220 human infections and almost 800 deaths spread
across 27 countries located in the Middle East, Europe, Asia, and the United States. Although dromedary camels
are the known reservoir of the virus, there is limited knowledge on the mechanisms and factors associated with
camel-to-human transmission, which remains the primary mechanism of human infections. Human outbreaks
and the number of documented cases of MERS-CoV continue to grow in the Middle East and Asia; however
there have, to date, been no documented cases of human disease in the eastern Africa countries where >65%
of the world’s dromedary camels are found. This is despite evidence of prevalent MERS-CoV infection of camels
in the region. The absence of human disease in East Africa may be explained by viral plasticity resulting in
inefficient transmission and/or weakened virulence, or poor disease surveillance and reporting among the
marginalized camel-owning nomadic pastoralist populations that inhabit remote arid lands of the regions. We will
test these hypotheses by conducting integrated longitudinal cohort studies within a closed community of naïve
pastoralists and their camel population that is known to sustain MERS-CoV circulation in Marsabit County,
Kenya, in order to determine the maintenance and transmission of the virus among camels, zoonotic
transmission to humans, and severity of human infections. To determine if the circulating MERS-CoV is
genetically and phenotypically distinct from known virus clades in the Middle East and Asia, we will isolate the
East African virus by collecting samples biweekly from an infant cohort (birth -1 year) of 211 camels, followed by
culture and isolation of the virus to performed genotypic and phenotypic comparison with the known clade viruses
To investigate whether a combination of weak surveillance and poor access to health care are responsible for
absence of disease, we will follow-up for a year, a cohort of 573 camel handlers through biweekly visits, weekly
telephone calls, and access to a toll-free number in order to intensively examine and test them for MERS-CoV
disease. In addition, we will identify, test, and follow-up >4500 in- and out-patients with respiratory illness at
Marsabit County Referral Hospital for 3 years. To assess the risk the virus poses to humans, we will determine
the level of viral shedding in camels, and relate this to the incidence of zoonotic transmission, and types of camel
contact that increase transmission risk. These studies will identify the type of virus circulating in East Africa,
increasing knowledge about plasticity of MERS-CoV and its impact on zoonotic transmission and disease. By
elucidating the frequency and mechanisms of zoonotic transmission, and progression to clinical human disease,
we will define the risk the virus poses to this community at the frontline of a newly emergent virulent virus by
virtue of their occupation and lifestyle, paving the way for development of improved surveillance and appropriate
prevention and control strategies.
项目总结
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Characterization of SARS-CoV-2 genetic evolution in vaccinated and non-vaccinated patients from the Kenyan population.
肯尼亚人群中已接种疫苗和未接种疫苗的患者中 SARS-CoV-2 遗传进化的特征。
- DOI:10.21203/rs.3.rs-3457875/v1
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Oyola,Samuel
- 通讯作者:Oyola,Samuel
Outbreak of Middle East Respiratory Syndrome Coronavirus in Camels and Probable Spillover Infection to Humans in Kenya.
肯尼亚骆驼中爆发中东呼吸综合症冠状病毒并可能蔓延至人类。
- DOI:10.3390/v14081743
- 发表时间:2022-08-09
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Seroprevalence and risk factors of SARS-CoV-2 infection in an urban informal settlement in Nairobi, Kenya, December 2020.
- DOI:10.12688/f1000research.72914.2
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Near-Complete SARS-CoV-2 Seroprevalence among Rural and Urban Kenyans despite Significant Vaccine Hesitancy and Refusal.
- DOI:10.3390/vaccines11010068
- 发表时间:2022-12-28
- 期刊:
- 影响因子:7.8
- 作者:Nasimiyu C;Ngere I;Dawa J;Amoth P;Oluga O;Ngunu C;Mirieri H;Gachohi J;Dayan M;Liku N;Njoroge R;Odinoh R;Owaka S;Khamadi SA;Konongoi SL;Galo S;Elamenya L;Mureithi M;Anzala O;Breiman R;Osoro E;Njenga MK
- 通讯作者:Njenga MK
High seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya.
- DOI:10.1016/j.ijid.2021.08.062
- 发表时间:2021-11
- 期刊:
- 影响因子:0
- 作者:Ngere I;Dawa J;Hunsperger E;Otieno N;Masika M;Amoth P;Makayotto L;Nasimiyu C;Gunn BM;Nyawanda B;Oluga O;Ngunu C;Mirieri H;Gachohi J;Marwanga D;Munywoki PK;Odhiambo D;Alando MD;Breiman RF;Anzala O;Njenga MK;Bulterys M;Herman-Roloff A;Osoro E
- 通讯作者:Osoro E
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M KARIUKI NJENGA其他文献
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{{ truncateString('M KARIUKI NJENGA', 18)}}的其他基金
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10893917 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
Emerging Infectious Diseases Research Center - East and Central Africa
新发传染病研究中心 - 东非和中非
- 批准号:
10464357 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10630848 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10472398 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10693978 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10352815 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
GH21-003, Advancing Public Health Research in Kenya
GH21-003,推进肯尼亚的公共卫生研究
- 批准号:
10820145 - 财政年份:2021
- 资助金额:
$ 120.97万 - 项目类别:
Emerging Infectious Diseases Research Center - East and Central Africa
新发传染病研究中心 - 东非和中非
- 批准号:
10171768 - 财政年份:2020
- 资助金额:
$ 120.97万 - 项目类别:
Emerging Infectious Diseases Research Center - East and Central Africa
新发传染病研究中心 - 东非和中非
- 批准号:
10427187 - 财政年份:2020
- 资助金额:
$ 120.97万 - 项目类别:
GH16-006: Conducting Communicable Disease Research in Kenya
GH16-006:在肯尼亚进行传染病研究
- 批准号:
9341941 - 财政年份:2016
- 资助金额:
$ 120.97万 - 项目类别:
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