GH21-003, Advancing Public Health Research in Kenya

GH21-003，推进肯尼亚的公共卫生研究

• 批准号: 10352815
• 负责人: M KARIUKI NJENGA
• 金额: $ 632.93万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10352815
• 关键词: GH21; 003; Advancing; Public; Health

SUMMARY (ADMINISTRATIVE CORE) Our Consortium consisting of Washington State University (WSU), the Liverpool School of Tropical Medicine (LSTM), and the Kenya Medical Research Institute (KEMRI) proposes to support KEMRI to develop and manage a highly cost-effective and sustainable KEMRI/CGHR Research Platform (KRP) in western Kenya (under “Category 1. Research Coordination and Administration” of the administrative core). The platform includes the population-based health and demographic surveillance systems, laboratories in Kisumu and Nairobi, clinical research centers in Kisumu, and offices and shared services at the Kisian campus, Kisumu. Between 2014 and 2020, KRP’s day-to-day management was changed three times to make it more efficient, transparent, affordable, and less contentious with KEMRI, CDC, and other partners. Currently, the platform is managed by KEMRI, with CDC (through its partners) contributing financially together with the other international partners who share the platform. WSU and LSTM have an excellent relationship with KEMRI and its partners and many years of administrative and technical expertise in Kenya. Following extensive discussions and agreements leading up to this joint application, WSU, LSTM, and KEMRI central leadership will support KEMRI/CGHR to implement a management plan to strengthen the Center’s capacity to assume cost-effective and sustainable management of the platform in support of their public health research in Kenya. This will include a phased introduction of financial and administrative management systems, mutually agreed systems for cost-sharing across all national and international partners sharing the facilities, close fiscal oversight by WSU, and mentorship and training. KEMRI has already taken critical steps to streamline the platform’s management and strengthen its leadership, including the appointment of three senior staff at KEMRI/CGHR, the revision of policies to enhance decision-making at the Center level, and commitment to providing its share of financial support. It also includes the rolling out of an electronic system for the management of grant and ethics applications. As part of “Category 2. Research Laboratory Administration”, we will maintain accreditation standards, quality assurance processes, and integrated biosafety and biosecurity systems to support KEMRI state-of-the-art laboratories. We will also introduce a laboratory information management system, including for effective management of samples and associated data. The KEMRI laboratories recently demonstrated their utility to the country by providing >70% of the country’s testing capacity for COVID-19 pandemic. In addition, we present evident technical expertise to lead the Research Core areas identified in the RFA, including HIV and TB, malaria, influenza, and other respiratory pathogens, zoonotic diseases, antimicrobial resistance, neglected tropical diseases, non-communicable diseases, and vaccine- preventable diseases. Experienced WSU and LSTM scientists will team up with KEMRI and CDC counterparts to design, implement, and publish research, an approach designed to train and mentor KEMRI scientists in applying and managing research funding. In the accompanying Research Core proposals, these teams describe field and laboratory activities that address each required outcome and objective of the RFA. Table 5 of this Administrative Core provides a work plan showing how each study will be implemented over the program’s 5-year duration.

摘要（行政核心） 我们的财团包括华盛顿州立大学（WSU），利物浦热带医学学校（LSTM）和 肯尼亚医学研究所（KEMRI）支持Kemri开发和管理高度成本效益的建议 以及肯尼亚西部的可持续Kemri/CGHR研究平台（KRP）（“类别1。研究协调和 行政核心的管理”。该平台包括基于人群的健康和人群 监视系统，Kisumu和内罗毕的实验室，Kisumu的临床研究中心以及办公室并共享 Kisumu Kisian校园的服务。在2014年至2020年之间，KRP的日常管理更改了三次 使其对Kemri，CDC和其他合作伙伴更有效，透明，负担得起且争议更少。现在， 该平台由Kemri管理，疾病预防控制中心（通过其合作伙伴）与其他人一起贡献 共享平台的国际合作伙伴。 WSU和LSTM与Kemri及其合作伙伴有着良好的关系 以及肯尼亚多年的行政和技术专业知识。经过广泛的讨论和协议 在此联合申请之前，WSU，LSTM和Kemri中央领导将支持Kemri/CGHR实施 管理计划加强中心的能力，以实现成本效益和可持续的管理 平台支持他们在肯尼亚的公共卫生研究。这将包括分阶段的财务引入和 行政管理系统，共同商定的系统，用于整个国家和国际的成本分布 合作伙伴分享了WSU的设施，密切的财政监督以及Mentalship和Training。凯姆（Kemri）已经至关重要 简化平台管理和加强领导的步骤，包括任命三名高级 Kemri/CGHR的工作人员，《修订政策以增强中心的决策》，并致力于提供 其财政支持所占的份额。它还包括从电子系统中推出赠款和 道德应用。作为“ 2类研究实验室管理”的一部分，我们将保持认证标准， 质量保证过程以及集成的生物安全和生物安全系统，以支持Kemri最先进的 实验室。我们还将引入实验室信息管理系统，包括有效管理 样本和相关数据。 Kemri实验室最近通过提供> 70％的 该国的COVID-19大流行的测试能力。此外，我们提供了证据技术专长，以领导 RFA中确定的研究核心区域，包括艾滋病毒和结核病，疟疾，影响和其他呼吸道病原体， 人畜共动性疾病，抗菌素抵抗，被忽视的热带疾病，非通信疾病和疫苗 - 可预防的疾病。经验丰富的WSU和LSTM科学家将与Kemri和CDC同行一起设计， 实施和发布研究，一种旨在培训和心理凯姆里科学家应用和管理的方法 研究资金。在参与的研究核心建议中，这些团队描述了现场和实验室活动 解决RFA的每个必需结果和目标。此行政核心的表5提供了一个工作计划 在该计划的5年持续时间内将如何实施每个研究。