Medical Scientist Training Program

医学科学家培训计划

• 批准号: 10651825
• 负责人: STEVEN L REINER
• 金额: $ 150.94万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10651825
• 关键词: Medical; Scientist; Training Programs

ABSTRACT The central mission of the Medical Scientist Training Program (MSTP) at Columbia University's Vagelos College of Physicians and Surgeons (VP&S) is to train clinician-scientists to become leaders in biomedical research. Growing complexity of medicine and science has made it challenging to sustain a robust pipeline of clinician-scientists into the biomedical workforce. The VP&S MSTP has implemented efficiencies to integrate medical and PhD research training that keep pace with the interdisciplinary, quantitative, collaborative, and diverse nature of biomedical scholarship. The VP&S MSTP has evolved a flexible curricular model, providing outstanding and efficient training and mentorship to support the output of committed, clinically fluent, biomedical researchers. Trainees undertake an 18-month preclinical medical curriculum followed by 2 clinical clerkships, then PhD research for 3.5-4.5 years, and finally the major block of clinical clerkships. Because of MSTP's emphasis on integration, preclinical students are engaged in PhD courses and lab rotations; and PhD students are engaged in a unique clinical competence program. After the 7 or 8 year MD-PhD program, trainees emerge as creative, rigorous, diligent, resilient scientists who are also exceptional and compassionate clinicians. Specific missions of VP&S MSTP include: 1) Enhancing reproducibility of biomedical research results through training in scientific rigor and transparency; 2) Promoting a training culture with highest standards to ensure the safety, ethics, and well-being of all; 3) Imparting appreciation and ability to work in diverse teams and cultivate inclusivity; and 4) Nurturing superb skills to communicate scientific findings to a wide range of audiences. Critical enhancements to the VP&S MSTP include abundant career mentoring to promote successful transition into dual-degree careers; training in rigorous research design, as well as quantitative, computational and statistical methods; and nurturing of ethics, responsibility, diversity, and inclusivity in biomedical research and clinical practice. The trainee cohort is superb and increasingly diverse. More than 130 outstanding investigators act as thesis mentors. Program leadership has decades of graduate and medical education experience. The duration of trainee appointments would be for the first 2 years of PhD research, and the projected number of trainees across all cohorts would be 116 students. Measurable objectives that VP&S MSTP intends to achieve are: 1) Maintaining or improving high levels of dual-degree attainment (98%) and rapid time to completion (7.7 years); 2) Increasing the frequency of rigorous, impactful, first-authored papers from 93% up to 100%; 3) Bettering the 5-yr average of underrepresented racial and ethnic minority trainees (23%) to a steady 30%; and 4) Inspiring post-grad training that will increase long-term alumni retention in research careers (70%) up to 80%. VP&S MSTP graduates genuinely learn how to discover new knowledge, translate discoveries to the clinic, and then guide others through this critical mission.

摘要 哥伦比亚大学Vagelos医学科学家培训计划(MSTP)的中心任务 S内科医学院旨在培养临床医生和科学家成为生物医学领域的领军人物 研究。医学和科学的日益复杂使得维持一条强大的 临床医生--进入生物医学工作的科学家。MSTP副总裁S已经实施了高效的整合 医学和博士研究培训，跟上跨学科、量化、协作和 生物医学学术的多样性。MSTP副总裁兼S发展了一种灵活的课程模式，提供 卓越而高效的培训和指导，以支持承诺、临床流利、 生物医学研究人员。学员将参加为期18个月的临床前医学课程，然后是2个月的临床课程。 助理，然后是3.5-4.5年的博士研究，最后是临床助理的主要障碍。因为. MSTP强调整合，临床前学生参与博士课程和实验室轮换；以及博士 学生们参与了一个独特的临床能力项目。在完成了7到8年的医学博士课程后， 受训者成为富有创造力、严谨、勤奋、适应力强的科学家，他们也是杰出的和富有同情心的 临床医生。MSTP副总裁S的具体任务包括：1)提高生物医学研究的重复性 通过科学严谨和透明的培训取得成果；2)促进最高级别的培训文化 确保所有人的安全、道德和福祉的标准；3)传授工作欣赏和能力 多样化的团队并培养包容性；以及4)培养高超的技能，向 广泛的观众群。对副总裁兼S MSTP的关键增强包括丰富的职业指导，以 促进成功过渡到双学位职业；严格的研究设计培训以及 量化、计算和统计方法；以及培养道德、责任、多样性和 生物医学研究和临床实践中的包容性。受训人员队伍非常优秀，而且越来越多样化。 130多名优秀研究人员担任论文导师。项目领导力已有数十年的毕业生经验 和医学教育经验。实习生的聘期为博士学位的头两年。 研究，预计所有队列的受训人员人数将为116名学生。可测量的 MSTP副总裁S打算实现的目标是：1)保持或提高高水平的双学位 达到(98%)和快速完成(7.7年)；2)增加严格、有影响力、 第一篇论文从93%上升到100%；3)改善了5年来代表不足的种族和 少数民族学员(23%)稳定在30%；以及4)鼓舞人心的研究生培训将增加长期 校友在研究职业中的留存率(70%)高达80%。MSTP副总裁S毕业生真心学习如何发现 新知识，将发现转化为临床，然后指导其他人完成这一关键任务。

项目成果

Genome editing with retroelements.

使用逆转录元素进行基因组编辑。

• DOI: 10.1126/science.adi3183
• 发表时间: 2023
• 期刊: Science (New York, N.Y.)
• 作者: Tang,Stephen;Sternberg,SamuelH
• 通讯作者: Sternberg,SamuelH