Medical Scientist Training Program

医学科学家培训计划

基本信息

  • 批准号:
    10651825
  • 负责人:
  • 金额:
    $ 150.94万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

ABSTRACT The central mission of the Medical Scientist Training Program (MSTP) at Columbia University's Vagelos College of Physicians and Surgeons (VP&S) is to train clinician-scientists to become leaders in biomedical research. Growing complexity of medicine and science has made it challenging to sustain a robust pipeline of clinician-scientists into the biomedical workforce. The VP&S MSTP has implemented efficiencies to integrate medical and PhD research training that keep pace with the interdisciplinary, quantitative, collaborative, and diverse nature of biomedical scholarship. The VP&S MSTP has evolved a flexible curricular model, providing outstanding and efficient training and mentorship to support the output of committed, clinically fluent, biomedical researchers. Trainees undertake an 18-month preclinical medical curriculum followed by 2 clinical clerkships, then PhD research for 3.5-4.5 years, and finally the major block of clinical clerkships. Because of MSTP's emphasis on integration, preclinical students are engaged in PhD courses and lab rotations; and PhD students are engaged in a unique clinical competence program. After the 7 or 8 year MD-PhD program, trainees emerge as creative, rigorous, diligent, resilient scientists who are also exceptional and compassionate clinicians. Specific missions of VP&S MSTP include: 1) Enhancing reproducibility of biomedical research results through training in scientific rigor and transparency; 2) Promoting a training culture with highest standards to ensure the safety, ethics, and well-being of all; 3) Imparting appreciation and ability to work in diverse teams and cultivate inclusivity; and 4) Nurturing superb skills to communicate scientific findings to a wide range of audiences. Critical enhancements to the VP&S MSTP include abundant career mentoring to promote successful transition into dual-degree careers; training in rigorous research design, as well as quantitative, computational and statistical methods; and nurturing of ethics, responsibility, diversity, and inclusivity in biomedical research and clinical practice. The trainee cohort is superb and increasingly diverse. More than 130 outstanding investigators act as thesis mentors. Program leadership has decades of graduate and medical education experience. The duration of trainee appointments would be for the first 2 years of PhD research, and the projected number of trainees across all cohorts would be 116 students. Measurable objectives that VP&S MSTP intends to achieve are: 1) Maintaining or improving high levels of dual-degree attainment (98%) and rapid time to completion (7.7 years); 2) Increasing the frequency of rigorous, impactful, first-authored papers from 93% up to 100%; 3) Bettering the 5-yr average of underrepresented racial and ethnic minority trainees (23%) to a steady 30%; and 4) Inspiring post-grad training that will increase long-term alumni retention in research careers (70%) up to 80%. VP&S MSTP graduates genuinely learn how to discover new knowledge, translate discoveries to the clinic, and then guide others through this critical mission.
摘要 哥伦比亚大学Vagelos医学科学家培训计划(MSTP)的中心使命 内科医生和外科医生学院(VP&S)旨在培养临床科学家成为生物医学领域的领导者。 research.医学和科学的日益复杂性使得维持一个强大的药物供应渠道变得具有挑战性。 临床科学家进入生物医学劳动力。VP&S MSTP实现了高效集成 医学和博士研究培训,跟上跨学科,定量,协作, 生物医学学术的多样性。VP&S MSTP发展了一种灵活的课程模式, 出色和高效的培训和指导,以支持承诺,临床流利, 生物医学研究人员。受训人员进行18个月的临床前医学课程,然后进行2个临床 实习,然后博士研究3.5-4.5年,最后是临床实习的主要部分。因为 MSTP的重点是整合,临床前学生从事博士课程和实验室轮换;和博士 学生们参与了一个独特的临床能力计划。经过7年或8年的MD-PhD课程, 受训者成为富有创造力、严谨、勤奋、有弹性的科学家,他们也是杰出的和富有同情心的。 临床医生VP&S MSTP的具体任务包括:1)提高生物医学研究的可重复性 通过科学严谨性和透明度的培训取得成果; 2)促进培训文化, 确保所有人的安全、道德和福祉的标准; 3)传授欣赏和工作能力, 多样化的团队和培养包容性;以及4)培养高超的技能,将科学发现传达给 广泛的观众。VP&S MSTP的关键增强功能包括丰富的职业指导, 促进成功过渡到双学位职业;严格的研究设计培训,以及 定量、计算和统计方法;培养道德、责任、多样性和 生物医学研究和临床实践的包容性。实习生队伍是一流的,而且越来越多样化。 130多名优秀研究人员担任论文导师。项目领导有几十年的研究生 医学教育经验。实习生的任期将为博士学位的前2年 预计所有学员的人数将为116名。可测量 VP&S MSTP打算实现的目标是:1)保持或提高双学位的高水平 实现(98%)和快速完成时间(7.7年); 2)增加严格,有影响力, 第一作者的论文从93%上升到100%; 3)改善代表性不足的种族和 少数族裔受训人员(23%)稳定在30%; 4)增加毕业后培训,这将增加长期 校友保留在研究生涯(70%)高达80%。VP&S MSTP毕业生真正学习如何发现 新知识,将发现转化为临床,然后指导他人完成这一关键使命。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Genome editing with retroelements.
使用逆转录元素进行基因组编辑。
  • DOI:
    10.1126/science.adi3183
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Tang,Stephen;Sternberg,SamuelH
  • 通讯作者:
    Sternberg,SamuelH
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{{ truncateString('STEVEN L REINER', 18)}}的其他基金

Strategies to predict and overcome resistance to cancer immunotherapy
预测和克服癌症免疫治疗耐药性的策略
  • 批准号:
    10638167
  • 财政年份:
    2023
  • 资助金额:
    $ 150.94万
  • 项目类别:
Medical Scientist Training Program
医学科学家培训计划
  • 批准号:
    10411530
  • 财政年份:
    2022
  • 资助金额:
    $ 150.94万
  • 项目类别:
Diversifying and Regenerating T Cell Function
T 细胞功能多样化和再生
  • 批准号:
    8767544
  • 财政年份:
    2014
  • 资助金额:
    $ 150.94万
  • 项目类别:
Diversifying and Regenerating T Cell Function
T 细胞功能多样化和再生
  • 批准号:
    9285723
  • 财政年份:
    2014
  • 资助金额:
    $ 150.94万
  • 项目类别:
Asymmetric CD8+ T Cell Division in the Initiation of Immunity
免疫启动过程中 CD8 T 细胞的不对称分裂
  • 批准号:
    8215835
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:
Self-renewing Lymphocyte Division in The Immune Response
免疫反应中的自我更新淋巴细胞分裂
  • 批准号:
    10395010
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:
Asymmetric CD8+ T Cell Division in the Initiation of Immunity
免疫启动过程中 CD8 T 细胞的不对称分裂
  • 批准号:
    7756658
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:
Asymmetric CD8+ T Cell Division in the Initiation of Immunity
免疫启动过程中 CD8 T 细胞的不对称分裂
  • 批准号:
    7555604
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:
Asymmetric CD8+ T Cell Division in the Initiation of Immunity
免疫启动过程中 CD8 T 细胞的不对称分裂
  • 批准号:
    7473390
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:
Asymmetric Lymphocyte Division in the Immune Response
免疫反应中淋巴细胞的不对称分裂
  • 批准号:
    9108825
  • 财政年份:
    2008
  • 资助金额:
    $ 150.94万
  • 项目类别:

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