Diversifying and Regenerating T Cell Function

T 细胞功能多样化和再生

• 批准号: 8767544
• 负责人: STEVEN L REINER
• 金额: $ 40万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8767544
• 关键词: Adopted; Antigens; BLR1 gene; Behavior; Biological; CD4 Positive T Lymphocytes; CD8B1 gene; Cell division; Cell physiology; Cells; Characteristics; Chronic; Communicable Diseases; Daughter; Effector Cell; Epithelial; Exhibits; Failure; Genus Mentha; Germ; Heterogeneity; Host Defense; IL2RA gene; Image; Immune response; Immunity; Impairment; Infection; Laboratories; Lead; Leukocytes; Life; Listeria monocytogenes; Listeriosis; Malignant Neoplasms; Memory; Methodology; Microbe; Mus; Mutant Strains Mice; Natural regeneration; Nature; Play; Process; Reporter; Resolution; Role; Siblings; Signal Transduction; Staging; Stem cells; Stream; Surface; T cell response; T memory cell; T-Lymphocyte; Taxes; Testing; Viral; adult stem cell; atypical protein kinase C; daughter cell; exhaustion; fighting; novel; novel strategies; pathogen; premature; progenitor; public health relevance; regenerative; response; segregation

DESCRIPTION (provided by applicant): T lymphocytes play a critical role in host defense against microbes and cancer. A remarkable feature of the signals that trigger T cell participation in the immune response is that every cell appears to have a mandate that assures its daughters will not uniformly adopt the same fate. This proposal develops novel methodologies to image the characteristics of dividing T cells during the course of an infectious disease. The aims of the project are to test the importance of unequal cellular inheritance in the earliest stages of the immune response, where an abundance of cell fate decisions are being made (Aim 1), in the re-challenge response wherein memory T cells may be mimicking the regenerative behavior of adult stem cells (Aim 2), and in chronic infection because this scenario may tax the regenerative limits of normal memory T cells (Aim 3). The studies proposed herein should offer novel approaches for maintaining lifelong immunity against chronic infections and for eliminating many life-threatening infectious diseases.

描述（由申请人提供）：T 淋巴细胞在宿主防御微生物和癌症方面发挥着关键作用。触发 T 细胞参与免疫反应的信号的一个显着特征是，每个细胞似乎都有一项任务，确保其子细胞不会一律采取相同的命运。该提案开发了新的方法来对传染病过程中分裂的 T 细胞的特征进行成像。该组织的目标 该项目的目的是测试在免疫反应的最早阶段（其中正在做出大量细胞命运决定）、在记忆 T 细胞可能模仿成体干细胞的再生行为的再攻击反应中（目标 2）以及在慢性感染中，不平等细胞遗传的重要性，因为这种情况可能会加重正常记忆 T 细胞的再生极限（目标 3）。本文提出的研究应该为维持针对慢性感染的终生免疫力和消除许多危及生命的传染病提供新的方法。