Diversifying and Regenerating T Cell Function

T 细胞功能多样化和再生

• 批准号: 9285723
• 负责人: STEVEN L REINER
• 金额: $ 40万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9285723
• 关键词: Adopted; Antigens; BLR1 gene; Behavior; Biological; CD4 Positive T Lymphocytes; CD8-Positive T-Lymphocytes; CD8B1 gene; Cell division; Cell physiology; Cells; Characteristics; Chronic; Communicable Diseases; Daughter; Effector Cell; Epithelial; Exhibits; Failure; Genetic Transcription; Genus Mentha; Germ; Heterogeneity; Host Defense; IL2RA gene; Image; Immune response; Immunity; Impairment; Infection; Laboratories; Lead; Leukocytes; Life; Listeria monocytogenes; Listeriosis; Malignant Neoplasms; Memory; Methodology; Microbe; Morphology; Mus; Mutant Strains Mice; Natural regeneration; Nature; Phenotype; Play; Process; Reporter; Role; Siblings; Signal Transduction; Stem cells; Stream; Surface; T memory cell; T-Lymphocyte; Taxes; Testing; Viral; adult stem cell; atypical protein kinase C; comparative; daughter cell; exhaustion; fighting; high resolution imaging; novel; novel strategies; pathogen; premature; progenitor; public health relevance; regenerative; response; segregation; stem-like cell; virtual

DESCRIPTION (provided by applicant): T lymphocytes play a critical role in host defense against microbes and cancer. A remarkable feature of the signals that trigger T cell participation in the immune response is that every cell appears to have a mandate that assures its daughters will not uniformly adopt the same fate. This proposal develops novel methodologies to image the characteristics of dividing T cells during the course of an infectious disease. The aims of the project are to test the importance of unequal cellular inheritance in the earliest stages of the immune response, where an abundance of cell fate decisions are being made (Aim 1), in the re-challenge response wherein memory T cells may be mimicking the regenerative behavior of adult stem cells (Aim 2), and in chronic infection because this scenario may tax the regenerative limits of normal memory T cells (Aim 3). The studies proposed herein should offer novel approaches for maintaining lifelong immunity against chronic infections and for eliminating many life-threatening infectious diseases.

描述（由申请人提供）：T淋巴细胞在宿主防御微生物和癌症中发挥关键作用。触发T细胞参与免疫反应的信号的一个显著特征是，每个细胞似乎都有一项任务，确保其子细胞不会统一地采取同样的命运。这一建议发展了新的方法来成像的特征分裂T细胞在感染性疾病的过程中。的目的